>Q88W22 ## B ## Bf ## Lactobacillus.plantarum ## DNA topoisomerase (EC 5.99.1.2 ## Lactobacillus plantarum ## DNA topoisomerase (EC 5.99.1.2). ## Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
MAASTTKAKPAAKRKTATKTATKRKSKTPAKKLVIVESPSKAKTIEKYLGRSYKVVASLG
HIRDLPKSKMGVDVDNDYEPHYISIRGKGDVIKGLRKEAKKAKAVYLASDPDREGEAIAW
HLSYLLGLDPKDKNRVVFNEITKDTVKNAFKEPRSIDMDLVDAQQARRILDRLVGYSISP
LLWKKVKKGLSAGRVQSIALDLIIQRENEIKAFKPQEYWTIDSEFQKGRSKFMASFYGTH
GKKQPLDDNDAVQKILGQLDRNGDFNVVKVVKKERKRFPAPPFTTSTMQQDANRKLNFRT
RKTMMAAQQLYEGINVGGKEGSVGLITYMRTDSTRISSIAKHEASQFLHKEYGAEYAATK
PVKGKLPEGAQDAHEAIRPSSVFRTPASIKDYLTKDQFRLYQLIWSRFVASQMTPEVLDT
MAVTIDQNDVQFRANGSKTKFAGFTKIYDKTEKNNVLPDLSEGDVVKLSKTDPQQHFTQP
PARYSEANLIKALEENGVGRPSTYAPTLDTIQRRYYVKLEARRFVPTELGEIVNDIIQEY
FPDVVNVGFTASLEEQLDATEEGKENWVKVVDSFYKPFSKEVATAEESMEKIQIKDELAG
FNCDICGAPMVVKMGRYGKFFACSRFPDCRNTKPIVKEIGVVCPQCKKGQVIERKSKKNR
IFYGCSRFPDCDFVSWDKPVGRDCPKDGHYLVEKKVKGGKQVLCPNGDYTENVQK
>CAG20859 ## B ## Bp ## Photobacterium.profundum ## Putative DNA topoisomerase I. ## Photobacterium profundum (Photobacterium sp. (strain SS9)) ## Putative DNA topoisomerase I. ## Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Photobacterium.
MGKSLVIVESPAKAKTINKYLGKDFIVKSSVGHVRDLPTGARNAGKKAAAQSTAGLSVEE
KARLKKIKDRKSLIGKMGVDPYNDWDAHYEVLPGKEKVVSELQKLAADADFIYLATDLDR
EGEAIAWHLREIIGGDDARYKRVVFNEITKNAIQQAFEEPGELNIDGVNAQQARRFLDRV
VGFMVSPLLWKKVARGLSAGRVQSVAVKLIVEREREIKAFTPEEFWDIHANTLTVGKDAL
RLIVSQQAGKAFRPVNEAQTMAAKSVLDSAEYKVVDREDRPTSSKPSAPYITSTLQQAAS
TRLGYGVKRTMGLAQRLYEAGYITYMRTDSTNLSNDAVVAAREFIGSEYGENYLPKEAIK
YGSKKNAQEAHEAIRPSSVEVQAENLEGMDADAVKLYDLIWRQFVSCQMVPAKYDSSTIT
VQADEFTLKAKGRILRFAGWTLVQRPSGKNEDTTLPIVHVGDVMILEGVEPKQHFTKPPA
RFTEAALVKELEKRGIGRPSTYASIISTIQDRGYVRVDQRRFYAEKMGEIVSDRLDGSFP
DLMDFDFTARMEGNLDKIAEGEKNWKAVLDNFFSDFTTELERAELDEDEGGMKPNNIVVT
DIECPTCSRPMGIRTASTGVFLGCSGYALPPKERCKKTINLGDEDGIVNVLEEDVETAAL
RAKKRCPKCDTAMDAYLIDQDRKLHVCGNNPSCDGYIVEKGEFKLKGYEGPLIECDKCGS
DMELKTGRFGKYMGCTNEDCKNTRKILKNGEIAPPKEDPVHLPEIPCTQDSNAYFVLRDG
ASGLFMAASTFPKSRETRAPLVSELVRFKDRLSPKFYYLAEAPTEDPDGREAVVRFSRKS
KENYVRTEVDGKPSGWTGLYVDGKWEITDKRKKPKKEKAEKED
>Q7V627 ## B ## Bo ## Prochlorococcus.marinus ## Prokaryotic DNA topoisomerase  ## Prochlorococcus marinus (strain MIT 9313) ## Prokaryotic DNA topoisomerase (EC 5.99.1.2). ## Bacteria; Cyanobacteria; Prochlorophytes; Prochlorococcaceae; Prochlorococcus.
MQLACRCDKDWNGYISSVANTLVIVESPTKARTIRGFLPKDFRVEASMGHVRDLPNNASE
IPAAQKGQKWANLGVNTTADFEPLYVVPKDKKKVVKELKAALKEADQLLLATDEDREGES
ISWHLLQLLAPKVPVKRMVFHEITKEAIAKALDQPRDLDMELVHAQETRRILDRLVGYTL
SPLLWKKVAWGLSAGRVQSVAVRLLVQRERARRAFRSGSYWDLKAKLDKGGGQFEARLTS
LAGQKIATGSDFDETTGALKAGRNVRLLGESDARTLSESVRSSQWRVEAVEEKPTVRKPV
PPFTTSTLQQEANRKLRFSARETMRCAQGLYERGFITYMRTDSVHLSDQAIQAARSCVGS
RYGDDYLSKTPRQFSTKSRNAQEAHEAIRPAGESFRSPSGSGLEGRDMALYELIWKRTVA
SQMAEARLTMLAVDLRVADAKFRATGKRIDFPGFFRAYVEGSDDPDAALEGQEVLLPDLA
VDDSPTLQDVEALGHQTQPPARYSEASLVKMLEKEGIGRPSTYASIIGTIVDRGYAALQN
NSLTPSFTAFAVTALLEEHFPDLVDTSFTARMEFTLDEISTGKVQWLPYLEGFYKGEQGL
ESQVQQREGDIDSSVSRTVDLEGLPCVVRIGRFGAYLEAKRVGDDGEEESLKATLPQEIT
PADLDAEKAELILKQKADGPESIGEDPETGDQVYLLFGQYGPYVQRGQVGEDNPKPKRAS
LPKGKKPDELSLDEALGLLRLPRLLGEHPDGGRIQAGLGRFGPYVVWDKSKGEKDYRSLK
GEDDVLAVGLSRALELLAMPKRGRGGRTALKDLGIPEGSEEKVQVFDGPYGLYVKQGKLN
ASLPEGKGVDDISLDVAVELLAAKALSKKTSRRKKSTSTTSKKTAASKPKTRKPPATTKT
GRLRASAVRVIKPGEV
>Q8YC66 ## B ## Bp ## Brucella.melitensis ## DNA topoisomerase I (EC 5.99.1 ## Brucella melitensis ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Brucellaceae; Brucella.
MEGNLFHAARRFRASVGREFRLLYMNVVVVESPAKAKTINKYLGSDYKVLASFGHVRDLP
AKDGSVRPDEDFAMSWEVDSNSAKRLADIVKALKDSDGLILATDPDREGEAISWHVLEVL
RQKKALNGKTVKRVAFNAITKKAVLDAIAHPRDIDEPLVDAYLARRALDYLVGFTLSPVL
WRKLPGARSAGRVQSVALRLVCDREAEIERFVREEYWNIAALLKTPRNDSFTARLTALDG
KKLGKLDIKNGEQAGAIRTMLESANFKAVSVEAKPTKRNPGPPFTTSTLQQAASGQLGFS
ASRTMQVAQRLYEGVDIGGETAGLITYMRTDGVQIAPEAINAARDAIAKSFGAKYVPEKP
RYYSSKAKNAQEAHEAIRPTDFSRHPKDVRRFLDEDQARLYELIWKRAIASQMQAADIER
TTVDIEATNGSRAAMLRANGSVTKFDGFLAAYMDHREEEDDDEESAKLPEIRSGEALARE
KIDATQHSTEPPPRYSEATLIKKMEELGIGRPSTYAATLATLRDREYIIIDKRKLIPEAK
GRLVTAFLESFFERYVEYDFTADLEEKLDLISDGKLSWKEILRDFWRAFSGSVEDIKELR
VTNVLDALNEELAPLVFPAREDGSDPRSCPTCGTGTLSLKLGRYGAFVGCSNYPECKYTR
QLGGEANGETAASDEPKPLGKDPFTGEEITARTGRFGPYIQRGEGKEAKRASLPKGWTLD
TVDHEKAIALLSLPRDIGLHPETGKMISAGIGRYGPYVSHDGTFANLENVEEVFSVGLNR
AVSVLADKQSKGGGRGRSTPAALATLGDHPDGGAITVRDGRYGPYVNWGKVNATLPKGKD
PASVTLEEALALITEKAGSSKGRKAPARKSAASSEKKTTAKKTATKKAPAKAKSKAKAAE
E
>Q9Z7D7 ## B ## Bo ## Chlamydia.pneumoniae ## DNA topoisomerase I-fused to S ## Chlamydia pneumoniae (Chlamydophila pneumoniae) ## DNA topoisomerase I-fused to SWI domain. ## Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydophila.
MKKSLIIVESPAKIKTLQKLLGSEFVFASSIGHIVDLPAKEFGIDVDHDFEPQYQVLPDK
QEVINHIRKLAAKCEKVYLSPDPDREGEAIAWHIANQLPDSPLIQRVSFNAITKNAVTEA
LKHPRTIDMALVNAQQARRLLDRIVGYKISPILSRKLQQRSGISAGRVQSVALKLVVDRE
KAIDAFVPVEYWNLRVLMQDPKTTKTFWAHLYAVQGKKWEKEIPEGKTENDVLLINSEEK
ARHYAELLEKSSYTITRVEAKAKRRFAPPPFITSTLQQEASRHFRFSASRTMSIAQTLYE
GVDLDSEDSTGLITYMRTDSVRVDPEALTTVREYIQQTFGKEYLPEKANVYTTKKMTQDA
HEAIRPTDINLTPDKLKNKLSDDQFKVYNLIWKRFVASQITPAIYDTLAVQITTDTEIDL
RASGSLLKFKGFLAVYEEKQDDENDQEEDHPLPPLHAQDALIKEEVSQEQAFTKPLPRFT
EASLVKELEKSGIGRPSTYATIMNKIQSREYTTKENQRLRPTELGKIISQFLETNFPRIM
DIGFTALMEDELELIADNKKPWKLLLQEFWTTFLPVVITAEKEAVIPRILTNIECSKCHK
GKLVKIWSKNSYFYGCSEYPECDYRTSEEELAFNKEDYAEDTPWDSPCPLCGGVMKVRHG
RYGTFLGCEKYPECRGTISIHKKGEEIEQEEPIPCPAIGCNGKIFKKRSRYNKIFYSCSE
YPECSVIGNSIDAVITKYSGTEKIPYKKKTPTKKKSSAKTTKAAKTPSKKGKAKSSVKKS
SEKKTGPLFLPSPDLAKMIGNEPVSRGEATKKIWDYIKEHQLQAPENKKLLVPDNNLATI
IGPNPIDMFQLSKHLSQHLTKVSNDESSASS
>AAR31096 ## B ## Bp ## Alcaligenes.eutrophus ## DNA topoisomerase. ## Alcaligenes eutrophus (Ralstonia eutropha) ## DNA topoisomerase. ## Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Wautersia.
MRLFIAEKPSVAKAIAGELGATGKGDGFIECGTDKVTWCFGHMLEQADPDEYTPDDVPRG
QSGKKVWRVDELPIIPESWILKPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE
VLEHFRNSKPVRRFWVSAQDSVSVKRGLAALKENTTYAGWADAARGRQRADWLIGMNLSR
AYTLRAQRGGSRALLTVGRVQTPTLALVVARDREIEAFKAVPYHTIRAVVQHAGGSFAAA
WKAKEDQAGLDSEGRLVDTAVADALVAAVKGQPGTIAAYKQEAKKQNQPLAFALSDITAL
ASAKFGYSAEDVLNTCQALYETHKLTSYPRTDCAYLPESQHADAPRVLEAIKHVNPELAG
LVDGADPRIKSKTWDDSKITAHHGIVPTMQKGSKAALSERERNIYDLIVRAYLAQFYPLH
EYMQTTVGVEIAGENFAASGKVVTRNGWRDVYSQADEEGEKDEDDDSGTQALPSMAQGDA
VTCTDATRKDAKTKPPARFTEGTLIRAMENIHKFVSDAEHKKMLREGDGIGTSATRASII
SELKRREFLAVKGKQIISTTLGRSVIDALPEVVKSPVLTALYERMLKGVEQGTAALDAFI
TKQETFIRDQVAKANSGAVTIAGGKEAAPVSSLHKCMACGSGLSRRPSKKKGQFWWGCSN
FPTCKQTYPDLKGRPDYSKGRNGPASE
>Q7X3D3 ## B ## Bo ## Gamma-proteobacterium.Hot ## DNA topoisomerase. ## Gamma-proteobacterium Hot 75m4 ## DNA topoisomerase. ## Bacteria; environmental samples.
MRLFIAEKPSVAKAIAGELGATGKGDGFIECGTDKVTWCFGHMLEQADPDEYTPDDVPRG
QSGKKVWRVDELPIIPESWILKPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE
VLEHFRNSKPVRRFWVSAQDSVSVKRGLAALKENTTYAGWADAARGRQRADWLIGMNLSR
AYTLRAQRGGSRALLTVGRVQTPTLALVVARDREIEAFKAVPYHTIRAVVQHAGGSFAAA
WKAKEDQAGLDSEGRLVDTAVADALVAAVKGQPGTIAAYKQEAKKQNQPLAFALSDITAL
ASAKFGYSAEDVLNTCQALYETHKLTSYPRTDCAYLPESQHADAPRVLEAIKHVNPELAG
LVDGADPRIKSKTWDDSKITAHHGIVPTMQKGSKAALSERERNIYDLIVRAYLAQFYPLH
EYMQTTVGVEIAGENFAASGKVVTRNGWRDVYSQADEEGEKDEDDDSGTQALPSMAQGDA
VTCTDATRKDAKTKPPARFTEGTLIRAMENIHKFVSDAEHKKMLREGDGIGTSATRASII
SELKRREFLAVKGKQIISTTLGRSVIDALPEVVKSPVLTALYERMLKGVEQGTAALDAFI
TKQETFIRDQVAKANSGAVTIAGGKEAAPVSSLHKCMACGSGLSRRPSKKKGQFWWGCSN
FPTCKQTYPDLKGRPDYSKGRNGPASE
>Q8FSS5 ## B ## Ba ## Corynebacterium.efficiens ## Putative DNA topoisomerase I. ## Corynebacterium efficiens ## Putative DNA topoisomerase I. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
MAEQQGSRKKSLVIVESATKARKIQPYLGNDYIVEASVGHIRDLPRGAADVPPKYKKEPW
ARLGVDTEHGFSPLYVVSPDKKKKVADLKAKLKECDELLLATDPDREGEAIAWHLLEVLK
PQVPVRRMVFNEITKPAILAAVENTRELDENLVDAQETRRILDRLYGYEVSPVLWKKVMP
RLSAGRVQSVATRVIVERERERMAFISADYWDLSAQFRIDSSAQADADNPSTFSARLATI
DGQRVAQGRDFNDRGELISDVVVVDKQRAEALAEALQGQEMSVASVEEKPYTRRPYAPFM
TSTLQQESGRKLHFTSERTMRIAQRLYENGHITYMRTDSTSLSEQGLKAARAQALELYGS
EYVSPTPRTYDRKVKNSQEAHEAIRPAGETFATPGQLHGQLDAEEFKLYELIWQRTVASQ
MADAKGTSMKVTIAGAATSGEKTEFTATGRTLTFPGFLRAYVETTPTADGRDVADNAEKR
LPRLTEGDALTATDITADGHSTNPPARYTEASLVKKMEDLGIGRPSTYASIIKTIQDRGY
VYSRGNALVPSWVAFAVVGLLEANFTSLVDYDFTSSMEDELDNIAAGREGRTEWLSGFYF
GDAEADDSMAESVARQGGLKALVDQNLEQIDARSVNSLKLFDDEQGRPVFVRVGRYGPYI
ERVVGTTPEGEPEYQRANLPEETTPDELSLEVAEKLFATPQGGRELGINPANGRMIVAKE
GRFGPYVTEQVTEDERAGAEAEAEKVVAAERKAEDEQRAADGMRAKNWETKTAATQKEKR
INQLVEETLKPATASLFSGMEPATVTLEEALKLLSLPREVGVDPSDGEMITAQNGRYGPY
LKKGTDSRSLSSEEQIFTVTLDEARRIYAEPKRRGRTAAQPPLKTLGDNDVSGKPMTVKD
GRFGPYVTDGITNASLRKGDVPESLTDARANELLSERRAKEAADGGAAKKTTKKTTKKTT
KKKTTKKTTAKKTTAKKTTAKRAPQTTKRVVKAGSRKQS
>TOP1_SYNY3 ## B ## Bo ## Synechocystis ## DNA topoisomerase I (EC 5.99.1 ## Synechocystis sp. (strain PCC 6803) ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Cyanobacteria; Chroococcales; Synechocystis.
MSKLVIVESPTKARTIRNYLPQDYRVEASMGHVRDLPASAEEVPAAYKDKSWANLGVNVE
DHFSPLYVIPKSKKKVVKELQTALKNADEVILATDEDREGESISWHLLQLLQPKVPIKRM
VFHEITQEAIRSALENCRDIDENLVHAQETRRILDRLVGYTLSPLLWKKIAWGLSAGRVQ
SVAVRLIVQRERARRAFKTAGYWDLKAELEQNKNPFQAKLMTLGGTKLANGSDFDPNTGA
LLPDKQVVVLDEAQAIALKERLTGKPWAVVNTEEKPGVRKPSPPFTTSTLQQEANRKLGI
SARDTMRVAQKLYEEGYITYMRTDSVHLSDQAVTAARNCVQQMYGKEYLSPQPKQYTTKS
KGAQEAHEAIRPAGTEFRIPNQTGLKDRELALYELIWKRTVACQMADARITQLSVLLKVE
DAEFRAAGKRIDFPGYFRAYVEGSDDPDAALENQEVILPPLKVGDRPNCREIDTVGHETQ
PPARYTEASLVKTLESEGVGRPSTYASIIGTIIDRGYVQMRSKALTPTFTAFAVVSLLES
HFPDLVDTGFTSRMEQKLDEIAIGKTQWLPYLQGFFLGESGLENQVKVRQDQIDPAIAKA
IELENLAAKVKIGKFGPYIEIPQGEEIITASIPQDLTPADLNPEQVAVLLKQKTEGPDKV
GIHPETGEPIFILIGAYGPYVQLGEATEENKKPKRTSLPKGVKPEDVTLEMAVGLLALPR
NLGEHPESGKNIKASLGRFGPYVVHDQGKDGKDYRSLKGDDDVLTITLERALELLAEPKR
GRGSRTPLKQLGLHPEDQEPVNLFKGPYGVYIKHGKVNASLPEGETEETITLEKALPLLA
EKAGSGKKTSRKKATTTAKGTKKTTSKKASATGTAKKTTTKRTTRKKAASPDQSSEAG
>Q91UX7 ## B ## Bp ## Escherichia.coli ## ORF1, virB1 (EC 5.99.1.2) (DNA ## Escherichia coli ## ORF1, virB1 (EC 5.99.1.2) (DNA topoisomerase). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
MKLMVVESPNKIKKLESILGGDWKVMASVGHIRDLPRNDLGIEQPGFTLNYEFIPPAKVG
DRTFPGGEERVARIRKEARNADMVYLASDPDREGEAIAWHLKETLGLDESEYMRVTFDAI
TPDVIKAALNKARKIDYDLVHAQEARRALDRMYGYLVSPLLSDMLGMSLSAGRVQSPAVR
LVVDQERRIKAFKKTSHFGAVVAFDGESWQAEWNTKPFISEDKPYVLDEALANRAAACRQ
FRVTDADSGPAKQSPPSPFSTSLLLQAASVSLKLDPEVTAKLAQKLFEQGVITYIRTDSV
NFSDEANAEIRAFAQGKGWALPDKPRKFKAKGDAQEAHEAIRPTHIDVEEAGEDDKQRAL
YRLIWQRSVASQLADAKYKVNTVTLEATDGAETFEFKAKGRVLVEQGWRVLTAKDAVKDE
EAGDGDEDDASGGKVPLLDVGSAKQADSGKLLRKETKPPARFTKASLIAKLEAEGVGRPS
TYPAIMQNIMSKGYLGEVKRFLEPTETGVLLVDQLVKAEFAFIELAFTRGLEEELDVIAD
GNCGYVEVVEPAFVQLQADIEAVGSSGAMKPRFPCPKCESGLRRYSPAGKTPFWCCTNAE
CKTFMDDVDNKPVERKTYACTTCGTGSMRRFKRKTGGGFLWACSTEGCKHFMDDDKGKPV
EPTVHTCPKCKAAPLRRYQKKDKETGKPKGGFGWFCTGEDCKTFLEDEKGSRWPSRRHLA
RPAASRCIGARASTATGGVAAASRRVAKPSWTTTRASQSSAHRRKPSPRKHKFVCQDGMS
WR
>Q7NQ71 ## B ## Bp ## Chromobacterium.violaceum ## DNA topoisomerase (EC 5.99.1.2 ## Chromobacterium violaceum ## DNA topoisomerase (EC 5.99.1.2). ## Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae; Chromobacterium.
MPTSLLIVESPSKAKTLKKYLGPDFEVLASYGHVRDLVPKNGAVDPEKDFAMKYQLIARN
SKHVDAIVSAVREADHVYLATDPDREGEAISWHLVQILNSKKLLKDKTAQRVVFHEITKN
AVLDAIQNPRDIAQDLVDAQQARRALDYLVGFNLSPLLWKKIRRGLSAGRVQSPALRLIC
ERENEIKAFVQQEYWSVHLDSHKSRTKFSAKLTTLGGKKLDQFDIPNEAEQASVLARLQG
LPATVGSIEKKKKSRSPAAPFTTSTLQQEAVRKLGMTTDRAMRTAQQLYEGMDIGQGTVG
LITYMRTDSVALANEAVEEIRGYIGLKWDADYLPKNPAVYKSKAKNAQEAHEAIRPTSIL
RTPEMVKPFLTTDQFKLYDMIWKRTLACQMAPAKFDTTSVDIMVGEGVFRASGQVQTFAG
FLAVYEEDVDDAEDEDNAKLPLLTEGEDLPVDKLYGEQHFTQPPPRFSEASLVKALEEFG
IGRPSTYASIISTLKDREYVILDKKRFLPTDTGDIVNKFLTEHFAQYVDYNFTAKLENQL
DEIANGGRQWVPVMDTFWKGFKKQIDEKESISRAEVTTESLDEDCPKCGKPLSIKFGKRG
RFIACTGYPECDYTRNMGETAEQAAEEAEAPTVIEGRSCPDCGGELHIKKGRYGKFIGCA
NYPKCKHIEPLEKPRETGVTCPECKTGQLIERKSRYGKLFYSCNTYPKCKYATWNPPIAE
PCPQCNWPILTIKTTKRRGTEKVCPQKECGYAEQIAPPEGKDAAPAEEA
>Q60215 ## B ## Bp ## Escherichia.coli ## TraE protein (EC 5.99.1.2) (DN ## Escherichia coli ## TraE protein (EC 5.99.1.2) (DNA topoisomerase). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
MQFERLVIAEKPELAKAIVEGLGGGSRKDGYYECGSDRVTWCYGHMLALLDPEDYDERYA
NWNMADLPIVHIPWRKKPSGDAGAKAQFKTILSLLKQAKSVVHAGDPDDEGQLLVDEILE
YANCRLPVQRLLINDNNVKIVRRQLAAMRDNREFAGLSAAAEARSVGDQLYGFNITRLYT
LAARAKGYQGLLSVGRVQTPILGLVVRRCRENAAHQKTYYYLVNGQFEVEGIQFPARYQV
ADGDPVDEKGRLSNKEHAEGIAAAVSGQPARIVSVTTKAKEAAAPLPYNLLKLQMDASRK
FGFKPDQVKDITQALREKHKLITYNRSDCEYLSEEQHGDAPGVLAAIAQTAPMLAAAAQR
ANPTIKSRAFNSSKVSAHHAIIPTESTADLSKLTDAEQKIYLLIARAYVAQFWPKHLYDQ
TDVLAQVGDHRFGVRSNVTTSPGWKILYKNDAGNEDLEGNADDIEQDLRKLRDGQAGTCT
DAKAEQQETKPQPLYTMESLLSDLTRVAKYIRDDRLRKILIEKDKGKQGEHGGIGTPATR
DSIIATLFERGYLVEKGKHIVSTPTGEELYDALPDTARFPDMTALWHEQQKAIQAGERDT
LSFVNELMEYIGAEVANIKDNGLNMKIDTHPCPSCGKPLRRLKKKDKNEYFWGCTGFADG
CKFACDDKGGKPVPREAPKVSELHKCMACGHGLSRRPGKKRGMFWWGCSNFPTCKQTYPD
LKGRPDYSKGRNGTNQE
>Q8CRF7 ## B ## Bf ## Staphylococcus.epidermidis ## DNA topoisomerase III topB. ## Staphylococcus epidermidis ## DNA topoisomerase III topB. ## Bacteria; Firmicutes; Bacillales; Staphylococcus.
MKSLILAEKPSVGRDIANALNLQQKSNGYIEGKQYIVTWALGHLVTNATPEQYNPSYKEW
NLEDLPIIPKKMKTVVISKTNRQFKIVKSLILDKNVKEIIIATDAGREGELVARLILDKV
GNKKPIKRLWISSVTKKAIQEGFKQLKNGNAYQNLYEAALARSEADWIVGINATRALTTK
YDAQLSLGRVQTPTIQIVKSRQDEINYFKPEKYYTLSINVDGYDLNLKQQKRYKDKKELE
LIEHKIKHQEGKILEVKGKNKKSYAQPLFNLTDLQQEAYKRYKMGPKETLNTLQHLYERH
KLVTYPRTDSNYLTDDMVDTIQERLRAILATDYKSHVRDLISESFSSKMHIFNNQKVSDH
HAIIPTEVRPSIEQLSQREFKIYMLIAERFLENLMNPYLYEVLTIHAQLKDYNFVLKEII
PKQLGYKALKDQTSSHTLTHSFKEGQLFKVHRIEIHEHETKAPEYFNEGSLLKAMENPQN
HIDLNDKKYAKTLKHSGGIGTVATRADIIEKLFNMNALESRDGKIKVTSKGKQILELSPS
ELTSPILTAQWEEKLMLIEKGKYNSQKFIQEMKNFTFKVVNKIKSSEQKYKHDNLTTTEC
PTCGKFMIKVKTKNGQMLVCQDPKCKTKKNIQRKTNARCPNCKKKMTLFGKGKEAVYRCV
CGHTETQSQMDKRMRDKTNGKVSRKEMKKYINKKEEIDNNPFKDALKNLKL
>TOP1_MYCPN ## B ## Bf ## Mycoplasma.pneumoniae ## DNA topoisomerase I (EC 5.99.1 ## Mycoplasma pneumoniae ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MSKNLVVIESPNKVKTLQKYLPNDFEIVSTIGHIREMVHKNFGFNEADYSPVWEDWTKSK
KKFSSLSFKGNLKGKKLLSKYDIIKSIKEKASKATNIYLATDPDREGEAISWHVYDVLDE
KDKSKCQRITFNEITKNAVLDALKNPREIDQSWVQSQFARQILDRMIGFRLSRLLNNYLS
AKSAGRVQSVALRFLEEREQEIRSFVPRFWWTLDVLLNPKAEGVREACANRSIPIVLREI
NPALRAGLKFEEEKSVSGIDFLDEASAKKFGEQLKGVFEVYNIDETKHYSSSPNSAYTTA
SLQKDAINKLGWSSKKVTLIAQHLYEGVSINGEQTALISYPRTDSTRLSAQFQQSCKEYI
LNHYGEKYLSNRIVSAKGKKGEKIIQDAHEAIHPTDINITPEMVKNAIKKDEFLLYRLIW
IRTVASLMADCKKSHTHIRFINDGNKFYASSKSLVFDGYRKIYEHFENKESNDLYIDLDK
IRVGDRFMAKDIKITARQTHPAARYTQASLIEALEKSNIGRPSTYNTMASVNLDRGYASL
NKHAFHVTQLGEQVNEELSKHFGKIINKEFTKNMEKSLDEIAENKKNYQEFLRDFWSNFK
EEVKLAEGSIQRVKKEKEFVGRDCPSCASPLLYRYTKRGNEKFVGCSNFPNCKYNEFSQN
KPNLTLEKLEELCPECNSQLVKRRTKFNPNKTFVGCSNFPRCRYIKKDNAS
>Q8XJQ4 ## B ## Bf ## Clostridium.perfringens ## DNA topoisomerase I. ## Clostridium perfringens ## DNA topoisomerase I. ## Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
MGQKLVIVESPAKAKTIEKYLGKNYVVEASMGHVRDLPKSQLGVDIENEYNPKYITIRGK
GELLSKLRKLAKKSDKIYLATDPDREGEAISWHLANVLKIDENENCRIEFNEITKDAVKN
SIKHPRKINCNLVDAQQARRVLDRLVGYEISPLLWRNVKWGLSAGRVQSAALKLICDREE
EIKKFNPEEYWTVDVKLKKGKKSFPVKLTTKNKKKIEIKNKEQADQIIDELKENEYIVSK
IKKGTKNKNPLAPFTTSTLQQEASKKLNFMTKKTMSVAQQLYEGVEVKKFGTVGLITYMR
TDSVRISKEAQEKALNFIDETYGKEYVPEESRVYKGKKNIQDAHEAIRPTYVEITPEIAK
ANLSNDQYKLYALIWKRFIASQMATCILNTNSLEIKNGDYTLRASGSTIKFDGFMKVYEY
ISGEEEESVLLPELEENEVLKEESIEGKQHFTQPPARYSEAAFVKLLEEKGIGRPSTYVP
TISTLISRKYVDREKKILIPTELGFIVNDILSNYFKQIVDTDFTAEMEVKLDNVEAGKES
WTHIVDEFFTPLKEDIEKAEKEISKVIIEDKVSDVPCDKCGRLMVIKHGRFGDFLACPGY
PECQNTKPIVEEVDANCPLCGGKILVKRSKKGNRFYGCSNYPECNFVSWYEPTNEKCPEC
GSYMVKRYSKSKGEYLQCSDKECKYEKIIEKNNDENNSEK
>Q8GQ10 ## B ## Bp ## Pseudomonas.aeruginosa ## Putative DNA topoisomerase III ## Pseudomonas aeruginosa ## Putative DNA topoisomerase III. ## Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
MRLFLCEKPSQGKDIGRILGATQRGEGCLNGSGVTVTWCIGHLVEAAPPEAYDEQLKRWS
VEQLPIIPQHWRVEVKPKTATQFKVVKALLAKATHLVIATDADREGELIAREIVELCGYR
GPIERLWLSALNDASIRAALGKLRPSAETLSMYHSALARSRADWLVGMNLSRLFTVLGRQ
AGYDGVLSVGRVQTPTLKLVVDRDREIARFVSVPYWAIAVSLFAGGSTFAAQWVPPDACT
DDAGRCLRQPVAQQTMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDV
QETLEIAQALYETHKATTYPRSDSGYLPESMFAEVPTVLDSLLKTDPSLRSIMGQLDRSQ
RSRAWNDGKVTAHHGIIPTLEPAKLSAMSEKELAVYRLIRSHYLAQFLPHHEFDRTVAKF
SCGGQNLAATGKQVVIPGWRQVLAEPQAEDGDGEGDTAVRAQVLPALPKLYEGLACQVAD
VDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIA
RGYLVKKGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAA
WISQLIAQYGSASLSIKVPQGPACPQCGAPTRQRSGKSGPFWSCSRYPDCKGTLPVESGS
SKRGASRPRRSGRKGS
>Q7MMB7 ## B ## Bp ## Vibrio.vulnificus ## Topoisomerase IA. ## Vibrio vulnificus (strain YJ016) ## Topoisomerase IA. ## Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
MTRLFIAEKPSLGRAIAAALPNPQKKEQGFIRCGNGDIVTWCIGHLLEQVEPDAYDERYK
KWNMADLPIIPEQWQLRPRPSASKQLTVIRKLLKEASEVIHAGDPDREGQLLVDEVLDYC
KLSQTKKAQTQRLLISDLNLPAVKRALSSLRSNRDFVPLSVSALARSRADWLYGMNMSRA
YTLLGQKAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVPRDFFTLHALIPYQNGSEPFDI
KARWKPSEACQPWQDEEGRVLSRKLVENVASRIANQPATVTESEHKQTKQAPPLPYSLSA
LQIDAAKRYGMSAQQVLDTCQSLYEKHKLITYPRSDNRYLPKEHYAQAASVSQAIANNAK
ELSDAVSGADLSLKSKAWNDSKVEAHHAIIPTPKQASVNALSGYEMKIYQLIARQYLMQF
YPAATYAEAKLVFEIAGGVFIAKGRQLTFAGWKALTGATEKEEDGADTVPPLAKGTVLTC
REGVIKDCKTEPPKHFTEATLLQAMTGIARYVSDKELKKILRETDGLGTEATRAGILDTL
FKRQLLSRQGKAILSTPAGRGLIHALPQESTYPDMTAHWEHQLQGMAERNQAYQPFMAAL
QQRISELMQQVTTSPVPSSLRQLPPVERPAFKRKRRASTSKKTASTATQKRTNKSA
>TP3A_DROME ## E ## Em ## Drosophila.melanogaster ## DNA topoisomerase III alpha (E ## Drosophila melanogaster (Fruit fly) ## DNA topoisomerase III alpha (EC 5.99.1.2). ## Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.
MKAVLTCFRPVVASHRRYCANPGQAMKYLNVAEKNDAAKTIAGLLSNGAAQRREGYSVYN
KVFDFEAPVRGQNAKMVMTSVSGHMMQLAFQVSYKNWRTVDPRSLFDAPVKKGVGSDYEP
IKRTLEREVRGCQGLIIWTDCDREGENIGYEIIDVCRAIKPNISVYRATFSEITTVAVRR
ALQQLGQPDKRQSDAVDVRTELDLRTGAAITRFQTMRLQRLFPEKIADKLISYGSCQIPT
LGFVAERYKEIEAFVSEPFWKIKVLHTIDDLTVEFNWARNRLFDKEACENYLLLCLAEPD
PRALVESVTVKPKHKWRPTPLDTVEMEKLGSRKLKLSAKETMTIAEKLYTKGFISYPRTE
TNQFSKEFALAPLVEMQTGHRDWGAFAQRVIEWGPNPRNGNKSDQAHPPIHPTKLAENLQ
GNEARVYELVVRHFLACVSKDAVGSETLVHIDIAGEKFTANGLVIHERNYLDVYVYDKWS
AKQIHHYENGQRFEPTEVSLHEGATTAPPLLTEADLIALMEKHGIGTDATHAEHINTIKE
RGYIGVLDKGFLVPGVIGMGLYEGYDAMELALAKPQLRAEFELDLKLICQGQKDPKVVLT
EQIAKYKQAYQQITDKITAMDAKISARINETPAANSAVQEGADGSAPSHGIIQSIFQCPK
CNEAPLALKPKKNQQGWYIGCNNFPDCKNAVWLPTECKDASVLDECCPTCGDGYRMLKFR
LSTPYYRGVFGTPSGWYKTCLPCDNLFRTTFNINLDSVKKVGGIVGEVRGGGGGPGPGPG
GGGSGRGAGSGGWSSGPGGGGSGGGGGSGGWGSGTGGGGSGGWGSGTGGGGLGGGKGKKP
GGESKKSATKKPPNEPKPKKTKEPKAAPNKKTSSKSSGSIRSFFTSAAPTNSASNGLDEF
FDSNDGFEDAMLAAAESVESSSQPKTISMVPLDDDIAAAFAADDDAEFEALVNGGTMPTE
SNGDQQLDKSLSEWIKEQDKADERPMLWGTRERASLGTAAPTPPPKPAAKRPRWDSVERD
STPPSSVPESETVLCTGCQQPARQNTVRKNGPNLGRLYYKCPKPDECNFFQWADEPPSSA
KSKNSTGSAPQSTTSWGSNRVVTLPSIQQSNSQRGQSSMRSNSSSTVTITQTKTKQQERN
TATPGDGEEVMCNCGQLASQLTVRKDGPNQGRPFYACPTREKSCGFFKWGDEDQNQGASS
TSWGSANRNPPGRSQPTAITSDGPKTRRCGLCRKEGHTRNKCPRKDEFDM
>Q84FA2 ## B ## Bp ## Myxococcus.xanthus ## Topoisomerase. ## Myxococcus xanthus ## Topoisomerase. ## Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales; Cystobacterineae; Myxococcaceae; Myxococcus.
MADAETDILTAEQQACLALWAVPGLGPRTLVALRAFADGSLAPLAATPVRDWVSQAPVSS
QVRRKLASVERLAPVAWRVWEACRASGMKVAFQGQAAYPERLAEVEDAPPVLFYRGVPGL
PRRRLAMVGSRHPDQGFLPFARRFARQVAASGVGVVSGAASGVDRACHWGALDEGGETWA
FLGSALDALDTAQARLLPHFLDRGGVFFSELPPGVRASTTTFPRRNRLISGASDAVLVLR
AGKDSGSLYTAEAGRAQGRPVFAMPGDVRQEEAAGCNALLRNGEAAVCLGPDDVWRVLKV
DPLAAVPPGTMGSWEDLSAEAKGGLRDVGPGSPELRRGAGRQHLLTGGARQRAGGVGIDG
AGHPAPRKAVRENLGRRVMATRTKKKVEETEAAEEKAPAKKAAAKKAAKKKPAAKKKTAA
KKTAARRRTKKGDEDELPTVEADAEEEATPRGKGPHYLVVVESPAKAKTIKKYLGSGYTV
KASVGHVKDLPKSKMGVDVEHDFQPEYTVIKGKEKVLNELKKMAKSADRVFLATDPDREG
EAIAWHIKEELAHPDALRVTFNEITKKAIQEAIAQPRQLNQDNYDSQQTRRILDRLVGYQ
ISPLLWKKVRRGLSAGRVQSVAVRLIVEREDEIKAFVPEEYWTLDALLEGPAGPPPFKAK
LSKLDGKKVELKERVFTESLVAELQTASFSVAKVDRRERRRNAPAPFITSKLQQEAANRL
SFTAKKTMTLAQRLYEGVPLGDEGQTALITYMRTDSTRLSDDAVKQVREFIDGKYGKDFL
PDEPMVYRSKKSAQDAHEAIRPTSLEYPPERVKPFFEAMGEEDMYRLYELIWKRFVACQM
KPAVYDQTSADIAAGRATFRASGSTLKFAGYLAVYGAGLTPEEEAEKEKAKAAGDENAEG
ADAVGELPVLNDGDALNLQKLLHEQHFTQPPPRFSEATLVKELEERGIGRPSTYAAILST
IQDKKYVEKLEGRFRPTDLGNMTNEMLVKHFPHELDVTFTATMEEKLDQISEGGANWKSV
LHDFYGPFKETLEKAEAEMRDVKREEIKTDIPCEKCGNLFVIKFGKMGHFLACSNYPDCK
NTKDFKRDAEGKIVMVEEETTDEVCEKCTKPMVIKRGRFGRFLACSGYPDCKTSKPISIG
VSCPECKEGYLTERRSGRGKIFFGCNRYPDCKFAAWDRPLAEPCPTCASPYLLQKFSKRD
GPYVACPNKECDYRREITEQPGGPGGSPEASSAA
>TOP1_ZYMMO ## B ## Bp ## Zymomonas.mobilis ## DNA topoisomerase I (EC 5.99.1 ## Zymomonas mobilis ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales; Sphingomonadaceae; Zymomonas.
MVRSIMKLVVVESPAKAKTIEKYLGSGYQVLASYGHIRDLPSKDGSVNPDNGFSMVWQNY
PDKAHRLKAIEDAVKESDSLILATDPDREGEAISWHILELLKTKKLLPDDVERVTFNAIT
KAAVTDAMAHPRQLDNDLINAYLARRALDYLVGFTLSPILWRKLPGAKSAGRVQSARLRL
VVDREQEIEGFKPQEYWSVEADMEADSIGFTSRLIQWRGQKLEKLSIADKTQAEAAQSDV
ESGHFTVSNVETKPVSRNPQPPFTTSTLQQEAARKLGFAASHTMRLAQSLYEEGLITYMR
TDGVQMDESAIAAARKTITQRYDGGYVPDKPRQYQVKAKNAQEAHEAIRPTDFSRDKAAS
GDHARLYELIWKRALASQMASAKLERTTVDLTDGTGQNVLRVTGQVVLFSGFLTLYEESA
DDNANDRDGKEGRARLPLLRAGDAPLKKEFRADQHFTQPPPRYSEASLVKKMEDLGIGRP
STYASFIQVLKDRAYVTLERNRFIPSEAGRLLTAFLERFFERYVSYDFTAGLEDSLDEIS
GGRADWQKVLDAFWHDFKPKTAEVMEQQPSAITAELDKFLEPWLFPDKGDGHDPRECPSC
HTGRLALKGGRFGAFIACSNYPECKYTRGFGQGEDGVDDNEPVLLGYMPENSDDDGYMAF
SDQGDILPANTASASETGVTDGGIAANAAFSGKGNSASHTDRDDLPFDPDEPASSTGNVA
SSQSRMTGDETASSGNSRDSSAHGVSTTAGIDAESQAGISNQALAGKNNAGRTAVSDNKG
NNSSSTIAAARKGGSTDDNATVSDPDGDIGSGASSSGQDADNRLLSHRNGDIDSRAIPAD
HKDSSSDQNASHALSPDRNSDDASVSNSDKKIDSKAVSTGHDVGNAITSDNSPSDNVAHL
ASTPSSATSSVKVALETENNDTAASKADEQAKEEEESRKARAVTRRTGRFGPYIQLGEGK
NAKRVSVPRDVNPREVDFSLASRLLALPREIGLHPESGKMIIAGTGRYGPYLNCDGKYAR
LFSTEELLDIDIDRAVVKLAEAAQNKGRTGATLSREPLKVFGDSPVTEKPVQLMNGRYGP
YVTDGETNASLPKDTTPESLTFEEALALLEARAKMPKKKKTKKAAAKKPAAKKTTTKKAA
PKKATTKTATPKSATTDNATSEDGDATPAKSPAKKAVAIKTTAKKPASKSATKKAPSSKT
TAAKKTSKATPKDEVAE
>RGY2_AQUAE ## B ## Bo ## Aquifex.aeolicus ## Reverse gyrase 2 [Includes: He ## Aquifex aeolicus ## Reverse gyrase 2 [Includes: Helicase (EC 3.6.1.-); Topoisomerase (EC 5.99.1.3)]. ## Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
MALELIERGCPNCGGVISSDRLEKGLPCSKCLPKPTEEKVCDALEELKTLKYLKPFCDTD
KSLERFINFFEKAVGAKPWSLQRVWAKRVFMNQSFAIVAPTGVGKTTFGLVMSLFLKGRV
LAIFPTRLLAQQAGDRLSELAQKVGVNKKILIYQSKKNIREQFLNGDWDILLGTNMFLHK
NFENLINFKFKLIFIDDIDSFLKRGKNVDYLFKLLGFSGEEIKLALKENKTQRDYDRLAR
IRKRKRDTVLIVSSATLKPRGKRAYLFRNLLGFDVQKAITTLRNIVDVAEPVKDLEEALE
KSVELIKKLGKGGLVYLSVFYGKDKVQEVKEFYRKHGINAVSYLDYKPEELYQILEKGEF
DVAVGISHITNPLVRGIDLPHIIRYAVFLDPPKHVFPTELTLSPPLLHGLLLTLLNLFEG
DDRLKAIQYVMYLKRYLTLREEQLDNYPRIKERVEEIKNFLENYLKDENFLKKIKESEDI
SLVPKEGKLYIVVGDANSYIQASGRTSRFIAGGMTKGLSVVYYSDPKAFYSLKKRLALYY
MTQEIEFKRLSEVDLNKLIKEIDEDRKRAREILQGKGVAQIKDLFKTTLVIVESPNKART
IAGFFGKPQMRLVEDSVAYEVPLGDRLLVITASLGHVLDLVTDKGFFGVLDDTYPYLPVY
DTIKICRETHEQHTEYEYLKKRCKGKIEDKLEIIKGVREVSYEVDEVFIATDPDAEGEKI
GYDLYLLSKPFNFNIKRAEFHEVTPKAFREAIQNPREVDLNLVKAQLVRRILDRWVGFTL
SHILWDAFGKKWLSAGRVQTPVLGWVIKRYEESKEKKGEILLHVNDFPLKIEIEDLMFAK
EIFKDLELADISLSNPQEEEKRPLPPYTTDTVLEDANEKLHLSAHKTMKILQELFEAGYI
TYHRTDSTRVSDAGKYLVAKPYITKMFGEEYFYPRSWGEGGAHECIRPTRPLEPKDLEFM
ITAGIAEFEDPENALKVYELIFKRFMASQMRPAKVITEEIILKLPYFEWKERVVTEVKEH
GFDLMYPTFKVFPKKEKLEITHKEFREVPKVYPYTQGTLIQEMKRRGLGRPSTYAQIVQT
LLERHYVVEEKGFLIPTDLGREVYEYLTKHFPEWTSEELTRKLEEAMDKIERGELDYMEV
LKEVHRIKVLLKEEKAFKK
>Q8G6Z5 ## B ## Ba ## Bifidobacterium.longum ## DNA topoisomerase I. ## Bifidobacterium longum ## DNA topoisomerase I. ## Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium.
MGMATKLVIVESPTKAHKIGDYLGKGYTVMASVGHIRDLAQPSQVPAADKAKFGKFGVDV
NDGFKPYYIVDGDKKRTVSELKSALKNADELYLATDEDREGEAIAWHLVQTLKPEVPVKR
MVFHEITKNAINASLNNTRDVDGNMVDAQETRRILDRLYGYELSPVLWRKVGPGLSAGRV
QSVATRLIVERERERMAFKRAPYWDIVATLSAPDALGERAEFSARMIALGGKRLAGSKDF
GADGQLTPDGFAANVRQLDEAGATAVASALKTADFTVMSMETKPYRRRPQPPFTTSTLQQ
TAGNRLGMGARAVMRAAQSLYENGYITYMRTDSVTLSQEGITAARNAVSYHFGDKFLSAE
PKQYATKTAGAQEAHECIRPAGSRFHDPDELASKLPGDQLRLYTLIWQRTLACQMADATG
STATVRLSAPAGPTEGEAVFQASGTVIEFPGFMKATGEGRKPKAAAPGAGAGSDQAAAAG
KTDAKAVRGDASESNTSLPPMSVGQQVEASDIEPDGHETQPPARYTEATLVKTLEAKEIG
RPSTYASIISTIMDRGYVYERGRALIPSWLAFSVTKLLETNFPKLVDYQFTAEMENGLDR
IAHGEESGRDWLTHFYFGSGEGAARNADEAHEGLQQQVAQLGEIDARAINTIDIGDGLHV
RVGRYGPYLEDMEHLDAEGNPKRASLPDTIAPDELTVAVARDLIDNHSGGPRELGVDPVS
GGTVEVRNGRFGPYVALVPPAEASAGAAGDTAGASAAKKGSKKAAAAAASRPKMASLFKT
MSPESLSLEDALKLLSLPREVGTYEETNAETGEVSECTVAANNGRYGPYLTKTGADGKSE
TRSLASEDEIFTVDIDKAKELFSQPKYGRGRGRGAAKPPLRDLGKDPNTGKNVTIKDGRF
GAYITDGETNRTVPRQYTPESITPDDAFRLLAEKRAAGPSTRGRRGAGRAGGAKAVAGKG
KKGGTSAAVSAQEAKRAERRAEVKKLANKGWSNQRIAEKLGSTPATVKKDVDWLTANEGY
ERPAVIPKRG
>Q9RUL0 ## B ## Bo ## Deinococcus.radiodurans ## DNA topoisomerase (EC 5.99.1.2 ## Deinococcus radiodurans ## DNA topoisomerase (EC 5.99.1.2). ## Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae; Deinococcus.
MGGPSVGQPQGKGPAGAAGRCVYAHRNFKPPAKVLTMPMPKTSPSKTLVIVESPAKAKTI
EKYLGQGYAVESSVGHIRDLPRSAADIPEKYKGQAWARLGLDVEHDFQPLYVVSPEKKQK
VAQLRKLAAEADEIILATDDDREGESIAWHLYQELKPKVPVKRMVFHEITREAIQAAIAA
PRQIDRNLVEAQEARRAVDRLYGYEVSPVLWRKVAPKLSAGRVQSVATRMLVERERERMR
FVAATWWDVVVTAQALTAQAGEQTFPARLTEVQGERLAAGKDFDPLTGQLRPGAGVRLLG
EAEALAISEGLKGQTLKVLTAEEKPFTSRPPAPFITSTLQQEGSRKLRMSAQTTMRTAQR
LYEGGYITYMRTDSTNLSSEAVNAARGQVKDMYGAPYLSPQPRVYAKKSKNAQEAHEAIR
PAGSTFRTPEQLRGELSGDEWRLYDLIWKRTVASQMSDARGRSLRVRLGGQTASGQTADS
VPVVLNASGRTIDFPGFLRAYVEGSDDPAAALEDRDTPLPPLKXGDAVRAQDVKAEDHET
QPPARYTEASLVQALEGAGIGRPSTYASILGTIQDRGYALKKGTALVPSWTAFATSALLE
HHFGTLVDYDFTAKMEEDLDEIAGGREHRVPYLRRFYLGEEGEGMALKPLIERQMGEIDA
RGIATIKVPKLEGSGIEVRVGRYGPYMQRGEDKANLPEGMTPDELTLEVAEELFSRPQGD
RVLGEDPESGHPVLARAGRYGPYVTLGNENPPLRSASLFPGEKLEDMTLERALQLLTLPR
LIGTSEGEEVWAHNGKFGPYLKRGSDSRSLATHEQLFTVTLPEAEALFQQPKFRGRGVAA
APLATYEYEGRTPILLKSGRFGPYLTDGEKNATLRKGEDLNTLDPQRARDILEERGKEPQ
KKPGKAGTKKAAASKAPAKAAASKTAPKKAAAKPAAKKAAPKKAASKSAKTPAAKAAPLT
WAQLKPFVGVLSEPERALVTATREQGRKVEDVAPELGLDVKKAKGMALQASKKLNQAARG
G
>TP3A_MOUSE ## E ## Em ## Mus.musculus ## DNA topoisomerase III alpha (E ## Mus musculus (Mouse) ## DNA topoisomerase III alpha (EC 5.99.1.2). ## Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus.
MIFPVTLLAFQWHRRPGGRALSRAAMEVAFRGVRKVLCVAEKNDAAKGIADLLSNGRMRR
KEGLSKFNKIYEFDYHLYGQNVTMIMTSVSGHLLAHDFQMQFRKWQSCNPLVLFEAEIEK
YCPENFIDIKKTLERETHHCQALVIWTDCDREGENIGFEIIHVCKAVKPNLRVLRARFSE
ITPHAVRTACENLTEPDQRVSDAVDVRQELDLRIGAAFTRFQTLRLQRIFPEVLAEQLIS
YGSCQFPTLGFVVERFKAIQAFVPEVFHKIKVTHDHKDGTVEFNWKRYRLFNHTACLVLY
QLCMEDPMATVVEVRSKPKSKWRPQALDTVELEKLASRKLRINAKETMRIAEKLYTQGYI
SYPRTETNIFPKDLNLVALVEQQTVDPHWGAFAQTILERGGPTPRNGSKSDQAHPPIHPT
KYTSGLQGDDRRLYEFIVRHFLACCSQDAQGQETTVEIDIAQERFVAHGLIILARNYLDV
YPYDHWSDKLLPVYEQGSHFQPSTVEMVDGETSPPQLLTEADLIALMEKHGIGTDATHAE
HIETIKARMYVGLTSDKRFLPGHLGMGLVEGYDSMGYEMSKPDLRAELEADLKLICEGKK
DKFQVLRQQVQKYKQVFIEAVAKAKKLDEALSQYLGERTEMAQQEEIYPAMPEPVRKCPQ
CNKDMVLKTKKSGGFYLSCMGFPECRSAVWFPDSVLEASRDNSVCSVCQPPPVYRLKLKF
KRGSLPPAMPLEFVGCIGGCDETLKEIFGLRFPRALPRASQPSGHLQASQALNRMDSSQH
NLSQPLVNRHTRPSKTVAQALLPPTTAGESNSVTCNCGREAVLLTVRKQGPNQGRHFYKC
SNGDCNFFLWADSSHSTGGGTPTSASGPPGSSVGCPSSVGSHMDGFGSLGSDSDGGTPCL
CGQPAVTRTVQKDGPNKGRQFHTCAKPREQQCGFFQWVDENVAPGSFAAPAWPGGRGKAQ
RPEAASKRPRAGSSDAGSTVKKPRKCSLCHQPGHTRTFCPQNR
>TOP1_STRCO ## B ## Ba ## Streptomyces.coelicolor ## DNA topoisomerase I (EC 5.99.1 ## Streptomyces coelicolor ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MSPTSETAKGGRRLVIVESPAKAKTIKGYLGPGYVVEASVGHIRDLPSGAAEVPEKYTGE
VRRLGVDVEHDFQPIYVVNADKKSQVKKLKDLLKESDELFLATDEDREGEAIAWHLQEVL
KPKIPVKRMVFHEITKDAIRAAVANPRELNQKLVDAQETRRILDRLYGYEVSPVLWKKVM
PRLSAGRVQSVATRLVVERERERIAFRSAEYWDLTGTFATGRAGDASDPSSLVARLQTVD
GRRVAQGRDFDSLGQLKSANTLHLDEANARALAAALENTRFAVRSVESKPYRRSPYAPFR
TTTLQQEASRKLGFGAKSTMQVAQKLYENGYITYMRTDSTTLSDTAVSAARAQVTQLYGA
DYLPPQPRTYAGKVKNAQEAHEAIRPSGDRFRTPAETGLTGDQFKLYELIWKRTVASQMK
DATGNSVTVKIGGAASDGRDVEFSASGKTITFHGFLKAYVEGADDPNAELDDRERRLPQV
AEGDALTAEEITVDGHATKPPARYTEASLVKELEEREIGRPSTYASIIGTILDRGYVFKK
GTALVPSFLSFAVVNLLEKHFGRLVDYDFTARMEDDLDRIARGEAQSVPWLRRFYFGEGD
GTGGGGAADAGNGDGDHLGGLKELVTDLGAIDAREVSSFPVGNDIKLRVGRYGPYVERGE
KDAENHQRADVPEDLAPDELSVELAEELLAKPSGDFELGTDPATGHAIVAKDGRYGPYVT
EVLPEGTPKTGKNAVKPRTASLFKSMSLDTVTLDDALKLMSLPRVVGADAEGVEITAQNG
RYGPYLKKGTDSRSLQTEDQLFEITLEEALAIYAQPKQRGRAAAKPPLKELGTDPVSEKP
VVVKDGRFGPYVTDGETNATLRSDDSVEEITPERGYELLAEKRAKGPAKKTAKKAVKKTA
AKKAPAKKAAATKKTAAAKTTAAKKTAAKSTAKKTTAKTAAKKATASKTSED
>TOP1_MYCLE ## B ## Ba ## Mycobacterium.leprae ## DNA topoisomerase I (EC 5.99.1 ## Mycobacterium leprae ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium.
MKGPRGSRSGRNGSPRRLVIVESPTKARKLSGYLGSAYIVESSRGHIRDLPRTAADVPAK
FKSEPWARLGVNVDADFEPLYIITPEKKSTVTELKGLLQGVDELYLATDGDREGEAIAWH
LMQTLKPRVPVKRMVFHEITEHAILAAAAHPRELDIDLVDAQETRRILDRLYGYEVSPVL
WKKVAPKLSAGRVQSVATRIIVQRERDRMAFCSAVYWDIVAKLDASVSDPTAQPLTFVAR
LTAVDGLRVATGRDFGAMGTLRGDCEVSKIIVLDDLTATTLAAGLRGAQLTVASAEEKLY
TRRPYPPFMTSTLQQEAGRKLRFSAERTMSIAQRLYENGYITYMRTDSTTLSESAINAAR
TQARQLYGEEYVSDSPRQYTRKVKNAQEAHEAIRPAGETFATPDAVCNELDGDEFRIYEL
VWRRTVASQMADARGTTLSLRIEGRAGEQHVVFSASGRTLTFPGFLKAYVETVDELAGGE
ADDAERRLPHLTSGQLLDVIDLTPDGHATNPPARYTEASLVKALEELGIGRPSTYSSIIK
TVQDRGYVQKKGSALVPSWVAFAVTGLLEQHFGRLVDYDFTAAMEDELDEIANGNEQRTN
WLNNFYFGGNHGVSDSIARSGGLKKLVGVNIEGIDAREVNSIKLFDDEHGRPVYVRVGKT
GPYLERLLAGDDGELTPQRANLNGTLTPDELTLEVAEELFATPHEGRVLGVDPETGHEIV
AKDGRYGPYVTEVLPKHDDDYGAADQGTKKTKKGRRASASQGPKPRTGSLLRSMDLQTIT
LEDALKLLLLPRVVGVDPASGEEITAQNGRYGPYLKRGKDSRPLTTEDQMFIITLDEALK
IYAEPKRAGRQSTSPPPLRELGTDPTSGKPMLIKDGRFGPYVTDGETNASLRKGDDVVSI
TDERAAELLADRRARGPVKRPAKKARKVPAKKAARLAPARGISQSPR
>Q7UMV5 ## B ## Bo ## Rhodopirellula.baltica ## DNA topoisomerase I (EC 5.99.1 ## Rhodopirellula baltica ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Planctomycetes; Planctomycetacia; Planctomycetales; Planctomycetaceae; Pirellula.
MSDKPESRTSETPIFPPRIGSFLLMAKSTSKSLVIVESPAKARTISKFLGSGYQVEASVG
HVRDLPGGAKDIPKKFKKEPWAYLGVNVEKDFEPVYIVPADKKKQVDKLKAALKDADSLY
LATDEDREGEAISWHLFELLKPKVPVHRLVFHEITKEAIQHALEDPREIDDGLVRAQETR
RILDRLYGYDVSQLLWKKVGRGLSAGRVQSVAVRLIVQRERERIAFHDATYWDLEAIFTT
DNGDSLPAMLATVDGRKIPTGKDFDSTNGQLINPELLQMDEQQAKELKQKLEKENFRVAK
VEVKPFTERPKAPFTTSTLQQEANRKLGFTARRCMQAAQRLYENGYITYMRTDSTTLSKE
AINAARDLVRSEYGEKFLHDSVRVYKGKVKNAQEAHEAIRPAGTPFRVPGAVQNELDRDQ
FRLFELIWKRTVACQMADAKKQRISVTIEGGGTTFTASGTSILFEGFLRAYVEGSDDPEA
ELADKERLLPAVNENDGLSVATLDPKSHTTQPPSRFSEASLTRTLEEKGIGRPSTYASII
DTIQRRDYVYKKGNALVPSWTAFSVIRLMETHFEPLVDYDFTAQMEDFLDTISRQEAESL
QYLKRFYFGDETEPTGDEKAAIGLKPRLESKIEEIDPRVTAKFSLGIPTEGENREEVFVR
VGKYGPFLEQGERKAPILEGMAPDEMTLARAMELFEDAAREDEPLGVHPETGKPIYIKAG
RFGPYVQMGEKDDEEKKNASILKTIAVEDVDLEMACKLLSLPRDLGEHPEMKEPILAHDG
RYGPYVKCGKETRSLPADKSPLDVTFDEAIELLKQPKTRGRAAPKEPIKKFEKPSPVTEN
EIKILEGRFGPYATDGETNASIPRGTDPKEMTFESVLDLLAERAAKGPTKKKKKKKAVKK
KTAKKAAKKKTAKKKAAKKKTAKAAAKKKGIIKKSS
>Q9LVP1 ## E ## Ep ## Arabidopsis.thaliana ## DNA topoisomerase III (EC 5.99 ## Arabidopsis thaliana (Mouse-ear cress) ## DNA topoisomerase III (EC 5.99.1.2). ## Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
MSRRGGGPVTVLNVAEKPSVAKSVAGILSRGTFRTREGRSRYNKIFEFDYAINGQPCRML
MTSVIGHLMELEFADRYRKWHSCDPADLYQAPVMKHVPEDKKDIKKTLEEEARKSDWLVL
WLDCDREGENIAFEVVDVCRAVKHNLFIRRAHFSALIDRDIHEAVQNLRDPNQLFAEAVD
ARQEIDLRIGASFTRFQTMLLRDRFAIDSTGEERSRVISYGPCQFPTLGFIVERYWEIQA
HEPEEFWTINCSHQSEEGLATFNWMRGHLFDYASAVILYEMCVEEPTATVMNVPHPRERF
KYPPYPLNTIELEKRASRYFRLSSEHTMKVAEELYQAGFISYPRTETDSFSSRTDLRAMV
EEQTRHPAWGSYAQRLLEPEGGLWRNPANGGHDDKAHPPIHPTKFSSGESNWSRDHLNVY
ELVVRHYLACVSQPAVAAETTVEIDIAGERFSASGRAILAKNYLEVYRFESWGGSVIPVY
EKGQQFIPTTLTLDAAVTRPPPLLCEADLLSCMDKAGIGTDATMHDHIKKLLDRGYATKD
ANTRFSPTNLGEALVMGYDDMGYELWKPNLRALMEHDMNEVSVGRKTKAEVLETCLQQMK
ACFLDARVKKSKLLEAMTIFFERSNNTDESESQTAGEVVRRCNLCNESDMALRKNRDGNF
MVGCMNYPQCRNAVWLPGPTLEASVTTNVCQSCGPGPVYKILFKFRQIGIPPGFDVNHLG
CVGGCDDILKQLIDICGTGSRSQARRTPGTAPSNNIQGSNTRQSNVCIHCQQRGHASTNC
PSRVPASRNSRPTATNPRNDESTVSCNTCGSQCVLRTANTEANRGRQFFSCPTQGCSFFA
WEDSINNSSGNATTGSNSGGSGRRGSRGRGRGGRGGQSSGGRRGSGTSFVSATGEPVSGI
RCFSCGDPSHFANACPNRNNSNGNYF
>CAE28565 ## B ## Bp ## Rhodopseudomonas.palustris ## DNA topoisomerase I (EC 5.99.1 ## Rhodopseudomonas palustris ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Rhodopseudomonas.
MNLVIVESPAKAKTINKYLGSSYEVLASFGHVRDLPAKNGSVDPDADFQMIWEVDPKAAS
RLNDIAKALKGADKLILATDPDREGEAISWHVLEVMKQKRALKDQQVERVVFNAITKQSV
TDAMKHPRQIDGALVDAYMARRALDYLVGFTLSPVLWRKLPGARSAGRVQSVALRLVCDR
ETEIEKFVPREYWSLIATMATPRGETFEARLVGADGKKIQRLDIGTGAEAEDFKKAIEAA
NFRVATVEAKPARRNPYAPFTTSTLQQEASRKLGFAPAHTMRVAQRLYEGVDIGGETVGL
ITYMRTDGVQIDSSAITQARKVIAEDFGNAYVPDAPRQYTAKAKNAQEAHEAIRPTDLSR
RPSDVSRNLDSDQARLYELIWIRTVASQMESAELERTTVDIEAKAGSRVLELRATGQVVK
FDGFLAAYQEGRDDDSEDEDSRRLPAMSENEALKREALAVTQHFTEPPPRFSEASLVKRM
EELGIGRPSTYASILQVLKDRGYVRLEKKRLHGEDKGRVVVAFLESFFTRYVEYDFTAGL
EEDLDRISNNEVSWKQVLSDFWRDFIGAVDEIKDLRVAQVLDVLDEMLGPHIYPAREDGG
DPRQCPSCGTGKLNLKAGKFGAFVGCSNYPECRYTRPLASDSAGDADRVLGTDPDSGLEV
AVKSGRFGPYIQLGEAKDYAEGEKPKRAGIPKGTSPSDVDLEMALKLLALPREVGKHPET
GQPIKAGIGRFGPYVQHEKTYASLEAGDDVHTIGLNRAVTLIAEKVAKGPSKGRFGSDPG
KALGDHPSLGAVAVKKGRYGAYVTAGGVNATIPNDKTEDTITLPEAIALLDERAAKGGGK
AKKAPAKKAAAKKASADGEAKPVKKAAAKKAKPKAEGAAASKARAPVAAKTAAKKAAKPK
DAAKSSAAKNG
>CAE78902 ## B ## Bp ## Bdellovibrio.bacteriovorus ## DNA topoisomerase I (EC 5.99.1 ## Bdellovibrio bacteriovorus ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Proteobacteria; Deltaproteobacteria; Bdellovibrionales; Bdellovibrionaceae; Bdellovibrio.
MAKKSDATDGIKLVIVESPTKAKTIRKFLGRDYVVESCMGHIRDLPQSAKDIPEKVKKEK
WAQLGVNVDKNFEPLYCVPKDKTKVVKNLKDKLEEASELYLATDEDREGESISWHLLEVL
KPKVPTKRMVFHEITKDAIQKALKDTREIDFNLVRAQEARRVLDRLVGYTISPLLWKKVA
YGLSAGRVQSVAVRLIVERELERVRFKKSSYWGVLAELSKDGVSFESRLQQYKNQRVATG
KDFDGLTGQLTAGKDVLVLDEKTAGKLSMDLKSGNWQVTDVEEKPTFRKPAPPFITSTLQ
QESNRKLGLSSRETMQVAQKLYEQGFITYMRTDSTFLSNEAITASRDCIESKYGKEYLTP
QPRNYAAKKVKGAQEAHEAIRPAGNQFMDPDETGLTGTQFRLYDLIWKRTIASQMVDARQ
KQVSAKITVGDALFGASGMTIEFPGFLRAYVEGSDDPEADLAEREVRLPALKVKDGVKCA
KLDPTSHETKPPARYTEASLVQTMEKEGIGRPSTYASVIGTIIDRGYVRKNGTALVPTFT
AMIVSKLLSQYLSQYVDLGFTSEMEQSLDNIADGELDWESYLASVYKGPKGLRAMVDNQG
DKIDPNEARTMTLEGMDKYKFHVGRYGAYVTTQRDGEDVSASLPDNESPADITPEIAEKL
IDQKINGADSLGNDPETDLPVYVLNGRYGPYVQLGDVTPEDDKPKRASLPPGTQPEQVDL
AMALSLLQLPKTLGTHPGTGKDIKAGLGRFGPFVVHDGDYRSIPKGESIFNITFEKAMEM
LAQPKKGRGRAAPLKELGAHPDSGDAIQVFNGPYGPYIKCGKVNASLPEGATPDTVTLEQ
AVALINEKGPAKGKGKAKGKAKAAPKAKAAKADGEKPAAKKPALKKAANAKEKAEALGVK
KVVTRKSKK
>Q9A5J6 ## B ## Bp ## Caulobacter.crescentus ## DNA topoisomerase (EC 5.99.1.2 ## Caulobacter crescentus ## DNA topoisomerase (EC 5.99.1.2). ## Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales; Caulobacteraceae; Caulobacter.
MNVVVVESPAKAKTINKYLGSDYTVLASYGHIRDLPSKDGSVEPDNDFAMSWEVDAKASK
RVSDIVDAMKKADRLILATDPDREGEAISWHVLEVLNKKKALKDKTVQRVTFNAITKTAV
TEAMKAPRDLDMELVEAYLARRALDYLVGFTLSPVLWRKLPGSRSAGRVQSVALRLVVDR
ELEIERFKTQEYWTVDADVSAGSDPFLARLVKHEGKKLTKFDLGNETSALTAKAAVEAAV
FKVEAVEKKPGKRSPAPPFTTSTLQQEAARKLGFSAQRTMQAAQKLYEGVDIGGETVGLI
TYMRTDGVSMAPEAIFEARDVIGAVYGKEYVPDSPRMYKSKAKNAQEAHEAIRPTAMGRN
PGSLRLEPELGRLYELIWKRTIASQMESARIERTTVDLTSADGQTGLRATGQVVQFPGYL
AVYEEGRDDEGDEDSARLPAITEGASAKVLKSRADQHFTEPPPRYSEASLVKKMEELGIG
RPSTYASVLGVLRDREYVRMEKQRFIPEDKGRLVTAFLEQFFKRYVEYDFTAALEEKLDL
VSDGKLDWKEFLREFWKDFHAAVGEIAELRTTNVLDALNEALGPHIFPDKGDGSNPRLCP
TCGSGQLSLKTGKFGAFIGCSNYPECRYTRQLGVSEGDGDAESADKQLGLNPATGLAVWL
KNGRFGPYVEELAAEGSSDKPKRSSLPKGWIASAMDMEKALRLLSLPREVGKHPDDGKVI
TAGLGRFGPFVLHDGTYANLENADEVFDVGLNRAVAILADKRAGGGRPQRGAAAALAELG
NHPEDGKPIRVLSGRFGPYIKHGDTNANVPKGKDPAAITLEEALALIAERAAKGGAKKPA
KKAAATKSKAKAESDAPAKKTAAKKPAAKKPAAKKAAPKAKAKATAASDDGAAPWDDEG
>Q8DHR4 ## B ## Bo ## Synechococcus.elongatus ## DNA topoisomerase I. ## Synechococcus elongatus (Thermosynechococcus elongatus) ## DNA topoisomerase I. ## Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
MSTLVIVESPAKARTIRKFLPPDYRVEASMGHVRDLPRSAADVPPEFRGEEWATLGVNVA
AGFEPLYIVPKEKQKVIKELKAALKTADELLLATDEDREGESISWHLLQLLEPKVPVRRM
VFHEITEEAIQEALHNCRDVNQQLVRAQETRRILDRLVGYTLSPLLWRKIAPHLSAGRVQ
SVAVRLLVQRERERLAFRKGQFWDLKATLDQRGTLFPARLVSVGGQRLATGNDFDPTTGQ
LRNPDAVLLLDEAAANALRDRLLTETWTVTEQEERQQTRKPAPPFTTSTLQQEANRKLHL
SAQETMRIAQKLYEEGYITYMRTDSVHLSDQAIAAARSCVEAMYGKAFLSPQPRQYTTKT
KGAQEAHEAIRPAGSQFRTPQETGLRDRELELYELIWKRTVASQMADARVTLLTVSITAG
DALFRAHGKRIDFPGFFRAYVEGSDDPDAALESQEVMLPVMQVGDILRCQALESVRHETQ
PPPRYTEASLVKALEQAGIGRPSTYATIISTIQDREYAIRRGNALEPTFTAFAVTALLEK
YFPDLVDINFTARMEQTLDDISTGEVQWQPYLESFYLGENGLEQQVKERERTIEATEARA
IALPELNAEVVVGRFGPFVVYQNGNGSEPIKASLPQDATPGSLTREQVEQLIRQKLEGPD
KLGVHPETGEPIFLLTGRFGPYVQLGEATEANPKPKRASLPKGVSPDEVTLDLAITLLSL
PRTLGVHPETGKLIQANQGRFGPYIVHDPEGEKDYRSLKGEDDVYTITLERALELLATPK
SSRARAKKQVLAVVGTHPEDGKLVQIFDGPYGPYVNHGKVNASLPEGVTPETMTLEQALL
LLAEKAPKKTRRSATATAPKPKSTIKRTSKKTATQTANTSRRKSTET
>Q8Y3B4 ## B ## Bp ## Ralstonia.solanacearum ## Probable DNA topoisomerase III ## Ralstonia solanacearum (Pseudomonas solanacearum) ## Probable DNA topoisomerase III protein (EC 5.99.1.2). ## Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Ralstonia.
MSKALIIAEKPSVAADIARALGGFTKHDEYYESDDHVLSSAVGHLVEIAAPDEYEVKRGK
WSFAHLPVIPPHFDLRPIAKSESRLKVLTRLIKRKDVTSLINACDAGREGELIFRLIAQH
ANTKLPIQRLWLQSMTPQAIRDGFAQLRSDNEMLPLADAARCRSEADWLVGINGTRAMTA
FNSKGGGFFLTTVGRVQTPTLSIVVEREEKIKRFVPRDYWEVRAEFIAAAGLYEGRWFDP
KFKKSEFDPEQRESRLWSEAEALSIVAACRDKPGMVTEESKPSTQMSPALFDLTSLQREA
NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYLGTVRQTLDMLADSSHNYLPH
AKKILASQWVKPNKRIFDNSKISDHFAIIPTLQAPKNLSEPEQKLYDLVVRRFLAVFFPA
AEYLVTTRVTEVAGHHFKTEGKVLVNPGWLVVYGRESQSKDDKENGNLVPVAKAEKVKTD
KVEPVSLTTKPPARYNEATLLSAMEGAGKLVDDDALREAMAGKGLGTPATRAAIIEGLLT
EKYLLREGRELIPTAKAFQLMTLLRGLGVEELTQAELTGEWEHKLAQIERGRLARDEFMR
EIAQMTQQIVKRAKEYDSDTIPGDYATLSTPCPQCGHVVKENYRRFACSHCDFSISKIPG
GRQFELEEVEELLINKTIGPLQGFRSKMGRPFAAILKLAQEDGHWKMEFDFGQNDGDEDG
EPVDFSGQESVGHCPKCSGNVYEHGLKYVCENAVAQPKTCDFTTGKIILQQEISREQLHK
LLAEGKTDLLTGFKSARTGRVFKAFLVKQPDGKIGFEFEPRGEGKAAAKKTTTAAKKTAA
AKAPAKTAAKKTTAAAKKTPARKKAATEADEESTSET
>Q7VSG5 ## B ## Bp ## Bordetella.pertussis ## DNA topoisomerase iii (EC 5.99 ## Bordetella pertussis ## DNA topoisomerase iii (EC 5.99.1.2). ## Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella.
MNKTLIIAEKPSVALDISRALGGFAREGDYFESDRYVLASSIGHLLSLVAPNDPVKGKWS
FTHLPVIPPAFELGPTDKKSAERLKLLVRLAKRKDVDAIINACDAGREGELIFRYIVQFA
GVKKPIQRLWLQSMTQQAIRDAFANLRDDEQLKPLEAAARSRAEADWLVGINGTRAMTAF
NSKDGGFFKTPVGRVQTPTLAIVNERENRIRSFVSRDYWEVHATFVAAAGLYEGRWIDPA
FRKDERDPEKRESRLWSLAAAQSVVAACRAQSGSVTEESKPSTQMSPALYDLTSLQREAN
GRFGFSAKTTLALAQTLYERHKALTYPRTDSRYLPEDYINTVRQTMQVLAQGDSNAVGAL
SRHADTVLAQNWVKPNRRIFDNKKVSDHFAIIPTLQVPRDLSEAEGKLYDLVLKRFLAVF
FPAAEYRVTTRLTEVQGHRFKTEGKVLVTPGWLAVYGKEAQGEDANLVPVADGETVRAED
VEAVGLATKPPARYNEATLLSAMEGAGKLVDDEELREAMSERGLGTPATRAAIIEGLLNE
AYLRRDGRDLVPTAKARQLMALLSGLDVSELTSPELTGEWEHKLKQIEQGALDRAAFMRE
IAQMTQVIVKRAKEYERDTVPGDYATLQTPCPKCGGVVKENYRRFACTQCDFSIGKHPGG
RTFELPEVEELLAKREIGPLQGCISKMGRPFAAILRISGEYKLEFDFGQNDEEDNEAVDF
SGHTPVGACPKCSARVFEHGMSYVCEKLVGLQKSCDFRSGKVILQQEISREQMEKLLTAG
RTDLLDGFVSSRTNRKFKAFLVRQPDGKVGFEFEPRGDKPGRPGAAAKKAAGKTATKTAA
KAPAKTAAKKAVKKAAPKKAATKTAAKKAAKKSAA
>TP3B_DROME ## E ## Em ## Drosophila.melanogaster ## DNA topoisomerase III beta (EC ## Drosophila melanogaster (Fruit fly) ## DNA topoisomerase III beta (EC 5.99.1.2). ## Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila.
MKSVLMVAEKPSLAASLAGILSNGRCTAKRGTGNGCSTHEWTGNFRNEGSVHFRMTSVCG
HVMSLDFNKKYNCWDKVDPIQLFGCATEKKETNPKQNMRKFLAHEARGCDYLVLWLDCDK
EGENICFEVMDAVKHVINNVYSDQVTYRAHFSAITEKDIKKAMETLGHPNENEAKSVDAR
QELDLRIGCAFTRFQTKFFQDRYGDLDSSLISYGPCQTPTLGFCVKRHDDIQTFKPESFW
HLQLLAGQPEVTLEWARGRVFKKDIAIMLLNRVKEHKKATVESVASKEAYKSKPQALNTV
ELMRICSSGLGIGPFQAMQIAERLYTQGYISYPRTETNQYPTNFDLPAVLHVLKPSADFG
EEARSILGDIQTPRKGKDAGDHPPITPMKLGNRSDFDRDTWRVYEFICRHFMGTVSRDLK
YRVTTAKLSVGMETFSCTASVLIDAGFTKVMTWSAFGKDEPQPPFVQGTQVAINDVRLIE
SQTGPPDYLTESELITLMEEHGIGTDASIPVHINNICQRNYVHIENGRKLMPTTLGIVLV
HGYQKIDPELVLPTMRTEVERMLTLIAQGSANFQDVLRHAIKIFKLKFMYFVKNIDSMDA
LFEVSFSPLAESGKAHSRCGKCRRYMKYIQTKPARLHCSHCDETYALPIGNVKVYREFKC
PLDDFDLLAFSTGVKGRSYPFCPYCYNHPPFSDMPHLGGCNTCTNANCPHSLNTLGISSC
VECPTGVLVLDCTLAPTWKLGCNRCDVIINCFKGATKITVEEAKCQECGAQQVNVVYKSD
KSKFKDGSEEKSGCIFCSADFSHLVEKHRAVASRPVRSGGGFRGGKAGRGGGGMGGAAFG
SGGAVTAGGGPNAGGGVRGSRVAKDKMGQLASYFV
>Q87ZB5 ## B ## Bp ## Pseudomonas.syringae ## DNA topoisomerase I. ## Pseudomonas syringae (pv. tomato) ## DNA topoisomerase I. ## Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
MGKSLVIVESPAKAKTINKYLGNQYVVKSSIGHIRDLPTSGSASAAKDPAAKRGKAAAGE
GPVLTPKEKAQRQLVSRMGVDPEHGWKAKYEILPGKEKVIEELRKLAKDADTIYLATDLD
REGEAIAWHLREAIGGDDSRYKRVVFNEITKKAIQEAFSRPGELDIARVNAQQARRFLDR
VVGYMVSPLLWQKVARGLSAGRVQSVAVKLVVEREREIRAFNPEEYWEIHADLGTAKGAN
VRFDVAREKGEAFKPLNEKQAMAALEKLKASSYSIVKREDKPTSSKPSAPFITSTLQQAA
SNRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSADAVSMARDYIETEFGKKYLPEAAN
VYSSKEGAQEAHEAIRPSDVNTHPSKLTGMERDAERLYELIWRQFVACQMLPAQYLSTTV
TVAAGDFELRAKGRILKFDGYTRALPQMAKPGDDDVLPDMAQGEVLKLNTLDPSQHFTKP
PARYSEASLVKEMEKRGIGRPSTYAAIISTIQDRGYVALHNRRFYSEKMGDIVTGRLSES
FANLMDYGFTAGMEENLDDVAKGQRDWKNVLDEFYGDFRKKLEVAEAPDSGMRANQPVMT
DIPCKVCARPMQIRTASTGVFLGCSGYSLPPKERCKATVNLTPGDEIADDDDESESRVLR
GKHRCPICSTAMDAYLLDEKHKLHICGNNPDCTGYEIEEGTYRIKGYEGPSLECDKCGSE
MQLKTGRFGKFFGCTNAECKNTRKLLKSGDAAPPKMDPVKMPELKCDKVDDTYILRDGAS
GLFLAASQFPKNRETRAPLVAEIAPHKDEIDPKYHFLCEAPKQDPDGRPTVIRYSRKTKE
QYVQTEVEGKPTGWRAFYDGSAWKVEDKR
>CAF22795 ## B ## Bo ## Parachlamydia ## Putative DNA topoisomerase I. ## Parachlamydia sp. UWE25 ## Putative DNA topoisomerase I. ## Bacteria; Chlamydiae; Chlamydiales; Parachlamydiaceae; Parachlamydia.
MGKALIIVESPAKIKTLKKFLGTNFIFESSIGHVRDLPEREFGIDIENDFEPKYTIMPNK
EEVISKLLKAAKQCDVVYLSPDPDREGEAIAWHITQVLPPNTNIKRVSFNSITKDAVVKA
LENPREIDIALVNAQQARRLLDRIVGYKISPLLNRRIQRGRENFLSAGRVQSVALKLVVD
REKEIEAFKPIEYWNIGAILKTNQEDRLFRAALYSVDGKRFEKEPIEGKEITIINNKEAA
DAILKRMKPGPYQVKKVERKEKRRFPVPPFITSTLQQEASRHHGFSSARTMNIAQGLYEG
VDLGSDGPEGLITYMRTDSVRISPEAVQEAREFIKKQYGSDFIPSDPKQYSTQKSAQDAH
EAIRPASLQNTPEKVQPYLTKEQFSLYQLIWRRFLASQMVAAIYDTVSADILAGEGILLR
ATGSIIKFQGFLAVYEEKNDDDEKDDENRMLPKLEEGQTLFLQELTSEQAFTRPPPRFTE
ASLVKELEKSGIGRPSTYAAIMNKIQSRDYTVKENGRLKPTELGQIIAQMLETSFQKIMN
IGFTAAMEDDLERVAENMKDWKTLIRDFWEQFNPTLEIALKEAFVPKVMTEIDCPKCKIG
KLQKVWARSKYFFGCSRYPECDYSSPVEEITFNKEDYATDFDWEQPCPNCNSEMKIRHGR
YGAFLGCTKYPECKGIINIPKKGEEALSQQDLPSCPAIECPGHMVARKSRFGKIFYSCST
FPECDVIVNNLEQVENKYPNHPRTPYEKKGKKAAAKTATKEKTKKTAKANASKATKKIKS
TPDKPKKVRQMPVYQVSPELRGIIEVSEITRGDMTKKVWDYIKTHQLQDTNNKRLIIPDA
KLSQVFGTTQPVDMFKMATLLSAHLKK
>Q7QAF0 ## E ## Em ## Anopheles.gambiae ## AgCP10348 (Fragment). ## Anopheles gambiae str. PEST ## AgCP10348 (Fragment). ## Eukaryota; Metazoa; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Anopheles; Anopheles gambiae.
NPRKPTFTMKVALMVAEKPSLAASLASILSNGKCSVRKGSNSACSVHEWVGQFRGETTRF
KMTSVCGHIMGLEFVGKYNSWDRVDPAELFACPTEKKESTPNLRMPYFLAQEARGCDYLI
LWLDCDKEGENICYEVMAAVSDSIHNVHSNRVTYRAKFSAITEKDIKYAMDNLIHPNENE
AKSVDARQELDLRIGCAFTRFQTKFFQGKYADLDASLISYGPCQTPTLGFCVQRHDEIQT
FKPETFWYVQVSVGESPEIKLEWHRVRVFEKEIACIYLNKVKEQKEAIVEAVSSKEQVRG
RPQALNTVELMRAASAGLGIGPHTAMQIAEKLYTRGYISYPRTETTQYPTNFDLNGVVRL
LQPSSEFGEEAKAIARDMTHPRKGNDAGDHPPITPMKLASRNELDGDSWRVYDYICRHFL
GTISRDLKYRTHTTKFRIGGELFTATTSALIDPGFTKVMTWQAFGKNELVHQFAVNDKVK
ISDVRLVESQTGPPDYLTESELISLMEKHGIGTDASIPVHINNICQRNYVAIGSGRTLTP
TNLGIVLVHGYQKIDPELVLPTMRSAVEQQLNLIAHGSADYRLVLKHAVEIFRLKFLYFV
QNISNMDILFESTFSSLSSSGKSLSRCGKCRRYMKYIQSKPARLHCPTCDETYTLPVKGS
IRVYRELKCPLDDFELVAWTNGAMGKAYPLCPYCYNHPPFRDMVKNSGCNNCPHPTCAHS
LSLLGVSSCMECERGVLVLDSTMTPKTWRLVCNGLCDVIVNCFADAVKVTVEAESCEECG
AQLVTAVYKQEKSPFKDEVTEKKGCIFCFAEFMPLVEKHKAVEMRRNHAGGRGGRGRGFR
GRGGKGGRGRNKAPKDKMTQLANYFV
>TP3B_HUMAN ## E ## Em ## Homo.sapiens ## DNA topoisomerase III beta-1 ( ## Homo sapiens (Human) ## DNA topoisomerase III beta-1 (EC 5.99.1.2). ## Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGH
VMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDK
EGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDA
RQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETY
WVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLA
LNTVEMLRVASSSLGMGPQHAMQTAERLYTQGYISYPRTETTHYPENFDLKGSLRQQANH
PYWADTVKRLLAEGINRPRKGHDAGDHPPITPMKSATEAELGGDAWRLYEYITRHFIATV
SHDCKYLQSTISFRIGPELFTCSGKTVLSPGFTEVMPWQSVPLEESLPTCQRGDAFPVGE
VKMLEKQTNPPDYLTEAELITLMEKHGIGTDASIPVHINNICQRNYVTVESGRRLKPTNL
GIVLVHGYYKIDAELVLPTIRSAVEKQLNLIAQGKADYRQVLGHTLDVFKRKFHYFVDSI
AGMDELMEVSFSPLAATGKPLSRCGKCHRFMKYIQAKPSRLHCSHCDETYTLPQNGTIKL
YKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSM
LGIGQCVECESGVLVLDPTSGPKWKVACNKCNVVAHCFENAHRVRVSADTCSVCEAALLD
VDFNKAKSPLPGDETQHMGCVFCDPVFQELVELKHAASCHPMHRGGPGRRQGRGRGRARR
PPGKPNPRRPKDKMSALAAYFV
>TOP1_BUCAI ## B ## Bp ## Buchnera.aphidicola ## DNA topoisomerase I (EC 5.99.1 ## Buchnera aphidicola (subsp. Acyrthosiphon pisum) (Acyrthosiphon pisum symbiotic bacterium) ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
MQKSLVIVESPAKAKTINQYLGSEYIVKSSIGHIRDLTKGKLYNKEKNKKFLNENFIEKT
NENKILIKQMGIDPYQNWKFEYHILPGKEKIISELKYIANQVKHIYLATDLDREGEAIAW
HLKEVIGGDSSKFSRVVFNEITQHSIQKAFKNVGHINMNRVHAQQARRFMDRIVGYMISP
LLWKKIARGLSAGRVQSVAVRIIADRESIIKNFVPEEYWKLDVSLISQDKKKINMDVTHY
NNKKFRPINENEVSFAVEKIQKSSCIVKNYEEKISYLKAPAPFITSTLQQSASLRLGFSV
KKTMFLAQKLYEEGYITYMRTDSNYLSEYAIKKVRKYIKSNYGSNYLPKEPNIYSNEKHS
QEAHEAIRPSDIKIKNIDSDHLNSSAKKLYELIWNQFLASQMKSVKYKSITVTVLADMFK
LQKSERIVMFQGWNKVLIEEKNVFSQFPILQTGSQLFINKVTPSQKFTKPPPRFSEASLV
RELEKKGIGRPSTYSAITSKIQDRGYVKIKKNKFYAEKMGEILTIRLKKSFSNLIDYNFT
AHMEKKLDQVAENKVTWRYLLDDFFKKFSEQLEQAKKSPEEGGMELNNIVPTSLNCPICC
KKMGIKTAITGVFLSCLGYNNTDNKKRCKKTINLITLNDFNKEQDNQKKISLQLIQKCDI
CNMYMDSYFINEKLKLHICANNPSCSGYKFEKGVFKSPIYLSKTIQCEKCYNNMKLKIGP
FGKFFTCINKICKNTRKILPNGEISDPKLEPIPFPELLCKQSDAWFVLREGISGIFFAAN
TFPKSRETRSPFVEELVRFQHLLPEKIYYLSSAPVIDNYGNKTIVCFDKKKKTHYIASKK
DGKFTGWSAVFIDQKWCVINK
>Q9U286 ## E ## Em ## Caenorhabditis.elegans ## Hypothetical protein Y48C3A.14 ## Caenorhabditis elegans ## Hypothetical protein Y48C3A.14. ## Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
MAPTVLMVAEKPLLADSIANLLSNGQAKKRKGWNGVCSVSEYDGQFNGRAARFKVTSTCG
HVMSLDFPPKFNNWERVDPAELYSAPTQRIEANPKMKMNEFLASEAKNADFLVLWLDCDK
EGENICFEVIDAVKCAMFKNRQDFMSDVYRAHFSAITEKDIKAAMRNLGRPDQNMSHSVD
ARQELDLRIGCSFTRFQTKFFQGKYGDLDSNVISYGPCQTPTLGFCVTRHDQIVQFKPEQ
YWVLKTNFTTSDDGQIFSPEWQRGRIFDAEVARVFVDRIKKCHTGLVLDVSKKEARKERP
CALNTVELMRVASSSLGMSPSTTMHVAEALYTQGYISYPRTETTAYSANFDLTGTLKILA
GDRKWGSVVLADGIKRPKSGVDKGDHPPITPMRPNHGGLSGDMSRIYEYVSQHFVATLMK
QCVYEVTTVKMSCGDEQFTLQGKNVVEPGFTAVMPWLSVEEECSVPKSLQQIGAKIELQN
AEIQARETTPPGYLTEAELITLMEKHGIGTDASIPVHINTITQRNYVTVESGRRLVPTRL
GQCLVRGYWKVDPELVLPTMRAELEEQLNLVASGKADYLDRNFEKKFLIENFIFFKTFFV
EKNENTGKPFSRCGKCRRYMKLVQTKPQRLYCPTCQETYAVPNFKDGVLKVIGDHKCPLD
DFDVILYQGPGGKLARTFTLCPFCFNNPPFEKMPQGAGCDTCVHPSCQYSISSNGVCGCL
QDCGGVMLLDTQSHPKWRMTCNKCPSVVGLFEGAIKVKVDSTRSCEQCDAQFIKAEFKPN
SGKPGAIEYESSSYEGCIFCDAMKKYPDAINLNHAYLTEESRQRNTQAPRRGGGGGRGRG
GRGRGGRGRGRGRGR
>MIMI_L221 ## V ## Vdd_Mimiviridae ## Mimivirus ## complement(267795..270359) Top ## Mimivirus ## complement(267795..270359) Topoisomerase I (bacterial type) ## Viruses; dsDNA viruses, no RNA stage; Mimiviridae.
MSILILLESPGKISKISSILGKNYVVKASMGHFRDLDPKKMSIDFDNDFEPVYIVTKPDV
VKNLKSAMKNIDLVYLAADEDREGEAIAQSLYDVLKPSNYKRLRFNAITKDAIMSAIKNA
GDIDKNLVDAQKARRVLDRLFGYLISPILQRQIGGKLSAGRVQSVTVRIIIDKENEIKNF
INKNADSSYFKVSGTFNGAKATLHESNDKKPFDLETAYKGKTAQIALINSENPNSKVVNF
MKRCLKSQFFIHSVEDKMTTRSPAPPFTTSTLQQEANRKFGMSIDSTMKTAQKLYEGGYI
TYMRTDSVEISAEGHRDIKKIITDQYGADYYQKNLYKNKAANSQEAHEAIRPTHPELLTL
EGEIEDAYQIKLYKLIWQRTIASQMKPAKIKVTIIQISISKYVEDKLNPFYYFQSQIETV
VFPGFMKVYVESIDDPDTDNQITKNFTGKIPTVGSKVTMEEIIARQEYMRPPPRYSEASL
VKKLEELGIGRPSTYVNTIKTIINREYVKITDVPGIKKDITIYSIKSENKKHIMEVYEDT
DTILLGKENKKIVPTNLGITVNDFLMKYFPEFLDYKFTANMETDLDYVSTGTKNWVDIVQ
DFYDKLKPIVDELSKQKGLSQSSERLLGEDNDGNEITATKTKFGPVVRKKIGDKYVYAKI
KDPLTLDTIKLSDAIKLLEYPKNLGQYKGFDVLLQKGDYGFYLSYNKENFSLGEIDDPED
INLDTAIKAIEAKKANNIAEFNLTENGKKIKAIVLNGKYGYYVQVTRNRIKKNYPIPKDL
DPNNLTEQQILSIISVKKTYKKSAPKGGSKTIRKPSQTKYSQTKSTKSTKSTKSTNKKFV
GKSAKKTTKKTTKK
>TOP1_BUCAP ## B ## Bp ## Buchnera.aphidicola ## DNA topoisomerase I (EC 5.99.1 ## Buchnera aphidicola (subsp. Schizaphis graminum) ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
MCKSLVIVESPVKAKTISKYLGKQYIVKSSVGHVRDLINNKSKNKKNIKKSNIKHNEKTA
LIQQMGINPYKNWKAEYHILPGKEKIISELKNIANKVHYIYLATDLDREGEAIAWHLKEV
IGGNSLKFRRVVFNEITKKSIEKAFQNIGKINMNRVYSQQARRFMDRIVGYMISPLLWKK
ISRGLSAGRVQSAAVRLITDREYEIKNFIEREHWKISLSLLSKENKKVTMDITHYRNKTF
LLNNKKEVNSTIEKIKNLSFIITDRKDKIFKKKPPAPLITSTLQQASNIDLGFSVKKTMF
LAQKLYEQGYITYIRTDSYFLSNYAIEKVRSYIENFYGSDFLPKKSNIYSNQKYSQEAHE
AIRPSDVQVVNIDNCDPDAKKLYKLIWNYFIASQMKSERYKSIKTTVMADVFKLQSNTKI
VLFSGWTKILKKSNNVNFKFPVLDIGTTLILDKILPHQIFTKPPPRFSESSLVRELEKKG
IGRPSTYATIITKIKEKGYLKIKKNKFYAAKIGEILITRLKKNFSDLVDYDFTARMEKNL
DQVSDKLINWKHLLNSFFDNFSQQLEQAKKPPEEGGMELNTTVPTEIDCSLCNKKMGIKT
AVTGVFLSCLGYNSEPNEKRCKNTINLISLNDLSTTKKEEKNFHLKNRCKKCNLVMDVYL
INENLKIFICINNPSCNGYNLKKGIFKKSLNCSLKKIKCEKCKNDMLFKTGRFGNFFMCI
NDTCKNTRKILPNGEISEPKFEPIPFPDILCEKSNTWFVLREGISGIFFAANTFPKSRET
RSPFVEELARFEYLLPKKLHYLASAPQRDNKGNKTIVCFNKLNKQQYIASKKEGKFTGWA
AFFIDRKWCIVNK
>TOP1_BORBU ## B ## Bo ## Borrelia.burgdorferi ## DNA topoisomerase I (EC 5.99.1 ## Borrelia burgdorferi (Lyme disease spirochete) ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Borrelia.
MQNKKLIIVESPTKAKTIKKFLDESFLVEACIGHVVDLPNNAKEIPKEYKKYEWANISID
YNNGFNPIYIIPSNKKPIVSKLKKLVKTINEIYLATDQDREGETIAFHLKEVLKIKNYKR
MIFHEITETAITESLKNTRNIDMNLVNAGEARRILDRLYGYTISPLLWKKVAYGLSAGRV
QSVGLKLLIEKEKTRINFKKANYYSILLQCKHEKKNLLLEAKLEEIDGKNIAEGKDFVNE
TGKLKNIAKTTIITQDLMIELEKELKNGQKIELISIETKKIKIPPPKPFTTSTLQQEINK
RLKIGTKQIMQHAQKLYEHGYITYMRTDSHNIAKIAKDKITKIIKNKYGKEYIEEKDRIY
EKEKMAQNAHEAIRPSEIFIPNETIEIESKTAKEIYKIIWDRTIISGMKDAIKENIKLTF
KYKNLIFRSSFTKIIFDGFLKHTKEQDEHLNINFDLIKKGDTFSIVKMKTSEHETKAPFR
YTEASLVQKMEKEGIGRPSTYSTIISTLLEREYAFKLNNTLMPTIKGAAVINLLEKYFPV
LIELNFTSNMEEKLDKIAIGKLDKIKYLSKFYNGKKGLKDTVMQLEPKIDSSEFRTVIES
QKIENKNSINYTINIGKYGPYLIFKGHNYSINAKTPLENLYKKDEIEKIINEKELKPNIL
GVDPLTGLNVIFKNTIYGNIVQLGEDTHAPQEYTKKGKPKKLKIIKAKKASTKKIDPENI
TLELALKLLSLPKPIGKHPQTNEQIIAATGVFGDYIKTESGSIACSLKKDLKAYDITLDK
AISLLNERANKVGIIVKTITFSKNKIGNKIYIYKKNDKFYAKIKRKKIDLPDNINLEEIN
EKYVFSLL
>Q8TPW5 ## A ## Ae ## Methanosarcina.acetivorans ## DNA topoisomerase, type I. ## Methanosarcina acetivorans ## DNA topoisomerase, type I. ## Archaea; Euryarchaeota; Euryarchaeota orders incertae sedis; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
MTVVAFAEKNKAAAQIASILGDGEVDKISVEGLPAYEFKWKGEEWLVMGLSGHIMNYDFP
EQYNKWSEVNPGTLLGVDPEKFVTRAEYATAIKKLAKRADKIILACDYDREGENIGFEAK
TLAEEVTDVPVARARFSALSPKEVRKAFESPVDPDHNLAMAAETRQILDLKMGAAFTRFV
TLSVREKARTKDILSIGPCQTPTCGFVYEREKAIRAFKAKDFWKITAIFGAKGGDFEGTH
RAGNIHDKEKAAEIFKRLKGAKEGFVVKKTVKEAKTSPPNPLNTTEFLKRASKFLGISPE
VALEVAEQLYLAGFTSYPRTETNKYADDFDFKTLLFDFARQKEYKPFAESILSAPIVPKN
GDKDAHDHPPIHPIRVAAKGEISAAVTIPHAAEVYDLIARHFLANLMPAAVFEKTHLHLQ
VREEPFDSSGTVLKDAGWLEVYPFENKKDKLLPFVEEKEKVDVKKLSNTKSKTSPPKKLT
EAELLTLMDKHGIGTKATAPTHIETNKKRGYFETKGKTVSILDTGFTLMDGLSLTVPILV
RPDIRAKIEALIQEVEDGKKEFEAALAEGTALIKEMYAQLEANKKELTSNIAGTIKDEAA
LEDKKNYIGTCKACGHVLRIVQTDTGRFVGCTGYPDCRNSFPLPKTGALTVLRSKECKKG
GAAVLKVGNKYNWAVGIGPCFKCELEKECYPPETVGPCPECDGSMFLISFKDSRFLGCTK
RCGYTHSVPKTGKLTLLDKTCETCGWKLFRLKEEEKPELDFCVNRRCPEGRKYWKQAGSR
TEPRDQAKVAAASSVPAPKVRAGRTPEAKSTPETRSMPRKAESPASGRVSKLSSTASRRK
ESK
>Q83FM2 ## B ## Ba ## Tropheryma.whipplei ## DNA topoisomerase I (EC 5.99.1 ## Tropheryma whipplei (strain Twist) (Whipple's bacillus) ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Cellulomonadaceae; Tropheryma.
MKKLVIVESPTKVSSVGRYLGDGYVVMSSVGHIRDLPAPSGLTPDLKRSAHAQFAVNIEN
DFEPYYVVLENKKKVVEELQSALNNSDELLIATDGDREGEAIAWHLVQVLKPTVPVRRLV
FHEITREAIAYALQHPRPIDENLVDAQEARRILDRLYGYELSPVLWKKVRPGLSAGRVQS
PATRLLVDRERERINFKSAEYQAVTADFQVDSDVFSASLTLFGERKIATGRDFDNLANLK
TDALVLDKNLTDRILEELKSKGALDVEAIDSKPYSRNPYAPFITSTLQQDAAHKLGFSAK
RTMRTAQQLYEKGFITYMRTDSPRLSLQAISAARAQVELLYGREFLPDSPRTYGAKAKNA
QEAHEAIRPTGEVFERPESIESVLSVDCMRLYDLIWRRTIASQMVSARGETVTLTLSARI
PERSIFVLSGTVLHEKGFLKVYEGLQDLNSKLLPNLQVGDQVTLVDVRAVGHTTLPPPRY
TEASLVKVLEELGLGRPSTYALILSTIQERGYAHLRNRMLVPDWLAFSVVNLLENFFSRL
IDYDFTANLEDQLDEIALGSQNRSDWLRKFYFGDDNLPGLKEIISGAKDIDARAINSIPM
VGATLRVGRYGPYLEVGDKRFSIPHDVYPDALTPEKIHELVNQPESPVRELGAHPETGKL
VVLKSGRFGPYIEEVSDEKNVRRSSLFKNMDPEEVNLDVAVKLLEIPRVIGVNQENGEKV
IACNGRFGPYIKCGKETRPLDSEDDILSVTLDEALAILSAPKVRRSRVLMEFPTDDPVTR
RAVQIKSGRFGPYVTDGVTNATLDNTSWEDVTFDEAVSLLAEKRQRVDGDLDQETAEKIH
V
>TOP1_SYNP7 ## B ## Bo ## Synechococcus ## DNA topoisomerase I (EC 5.99.1 ## Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2) ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
MPKLVIVESPTKARTIRNYLPKDYRVEASMGHVRDLPQSASDIPTELKGEKWSNLGVDVE
NNFAPLYIVPKDKKKIVKTLKDALKDADELILATDEDREGKVISWHLLQLLQPRCPRSAW
SFDEITQEAIQAAHEKLSGCRSAALVHAQETSQDSRSLGGLHPVGPALEKNCLGPIAGRV
QSVAVRLLVQRERARRAFRQGSYWDLKAQLTVEAGQFEAKLWTLAGQRLATGNDFDESTG
QIIAGRQVCLLDQQEAEALPIRRPDPALASKVAEEKPTHCANQRPPFTTSTLQQESNRKL
RLSARETMRVAQSLYERGFITYMRTDSVHLSQQAIEAARSCVEQMYGKNYLSPQPRQFTT
KSKNAQEAHEAIRPAGNTFRLPQETGLSGAEFAVYDLIWKRTIASQMAEARQTMLSVLLE
VDNAEFAPVASGSISRASSALSVEGSDDPDAALEDPRNSAAGVEGCGSPHLSGTGRESVM
KPQPPARYTEASLVKMLENEGIGRPSTYASIIGTIVDRGYAQLVSNTLTPTFTAFAVTAL
LEQHFPDLVDTSFSARMEQSLDDISNGEVDWLPYLSQFYRGDRGWKNRSNFAKVKLIRLP
LAQSRWRDCPPKSVLVVLALTRAEADGEPIKANLPKELTPADLDVQRVEHYCGKKPKGRT
NWEHILKPTSRFTCLRVPTVPTSNLGQPPRKNPSEAGFFAKGMSLETISLEQAVGLLSLP
RTLGEHPETGRRIQAGLGRFGPYVVCDLGGGEKDYRSLKADDDVLTIDLDRALELLAQPK
KSRGRGKEPIRRLASILMTKPPFKFLRVLRSLPQTWQGQCRCPRMRSRRRSAWKQQLQP
>Q7YYF5 ## E ## Eo ## Cryptosporidium.parvum ## DNA topoisomerase III beta-1,  ## Cryptosporidium parvum ## DNA topoisomerase III beta-1, probable. ## Eukaryota; Alveolata; Apicomplexa; Coccidia; Eimeriida; Cryptosporidiidae; Cryptosporidium.
MSPIKVLMVAEKPSISDTISRILSNGKLDTRRGKTPVHEFNGTFMGMNVQFRVTSVAGHV
FEIDFPQSYSNWEKTDPVSLFDAPIIKNESSSKMVSHLEKESKGCSYLVLWLDCDREGEN
ICFEVINVVSNNMSKGRDQRDWIFRAKFSSISPGDIFFAMKNLTFPNKNESDAVDVRQEL
DLKIGVAFSRLQTKYLKSKFGDFNKSSIISYGPCQTPTLFFTVQRRDSINSFIPEKYYTI
SATLSKDSQDINLIWSRSRVFELQVANCFLQLIQNKKPLSARVVDITSKNSRRIRPLPLN
TVSMLKLSSTILGIGPFQTLNIAEKLYLSGFTTYPRTETSRYPKNFDIKSTIAMFKNNSV
WGSYSSDLLQKGFNLPRKDGLDLGDHPPITPVRSATQNDLDGDSWRLYDLITRHFFATIS
NDIKMINRTIKFDLNGEIFIISGNQVIDHGFSVIQGRAACHESNIIPDFTLNEVVPIKNI
EILSKETKPPPILSESDLLSLMEKHGIGTDASMPTHIQKIQEREYVKLASGRRLEPTKLG
IALVHGIMNIDHELVLPKIRSEMEKYVDLIAKGKYNHKAVLKHSLSVFKLKFLYFAENIS
LFESLFRLGFTNITASCSRISRCGQCKRYLTYISNILPQRLYCSFCEIYLDIPQRGTIKI
YKELKCPIDDFELLLFIDQKGKKSIFCPRCYNDPPFLDAKENMLCKFCPHQTCNFSLKST
FFMACPSQDCRDGIITMDSSSTSDWRFDCSRCSISFSIKKNICERLSLGERCEKCGSRKL
KICKEKTSQEHFVGCPNCDEEILSLIEVISLPKLAYRSDVAKNSFRGGGKRGKRH
>Q82TD2 ## B ## Bp ## Nitrosomonas.europaea ## TopB; DNA topoisomerase III pr ## Nitrosomonas europaea ## TopB; DNA topoisomerase III protein (EC 5.99.1.2). ## Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales; Nitrosomonadaceae; Nitrosomonas.
MSKKLIIAEKPSVASDIARALGGFVKQKDYFESDEFVVSSAIGHLLELIVPEEYEVKRGK
WSFDHLPVIPPRFDLAPIEKTTDRLKLLSKLIKRKDVDMLINACDAGREGELIFRYIVRH
VGSKKPIKRLWLQSMTPSAIREAFANLLNDAEVQSLADAAVSRSEADWLVGINGTRVMTA
FNSQEGGFHKTTVGRVQTPTLAILVEREEAIKKFVVRDYWEVHATFQAESGVYKGKWFDE
GFSKRKDESESRADRIWDHAKAEVIRDKCAGRTGVVTEESKPSRENCPLLYDLTSLQRDA
NSRFGFSAKVTLGLAQALYEKHKVLTYPRTDSRALPEDYPAIVKDTLQVLKGSRYDRFAS
QILESDWVKPNKRIFNNAKVSDHFAIIPTALVPKKLNEAEEKLYDLVTKRFLAIFYPAAE
FLITTRITRVENEPFKTEGKVLVHAGWQTVYGKVESAQGQEEESVLVAVTPGETVLAQEV
AVVAGKTRPPARYNESTLLSAMEGAGKLVEDEELRAAMSAKGLGTPATRAAIIEGLIHEN
YVERSGRELQPTAKAFSLVTLLRGLKIPELISPELTGDWEFKLRQIEQGQLKRDVFMEKI
AAMTRHIVEQAKNHRDKTISGDFATLQVPCPGCGGVIKETYKKFQCQQCDFALWKILAGR
QFEAAEMETLISTREIGPLSGFRSKMGRAFNAIVRLTDDYEMKFDFGNEADQAQEKVDFS
AQQPLGKCPQCGHSVYEHKLLYVCEKSVGAGAPCSFRTGKIILNRAIEAEQVVKLLQTGR
TDLLAGFVSRKGRPFSAYLVVGPAGKIGFEFEQKKTKSKPADTVPETGKAAS
>Q8P4F3 ## B ## Bp ## Xanthomonas.campestris ## DNA topoisomerase I. ## Xanthomonas campestris (pv. campestris) ## DNA topoisomerase I. ## Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xanthomonas.
MPKHLLIVESPAKAKTINKYLGKDFTVLASYGHVRDLVPKEGAVDPDNGFAMRYDLIEKN
EKHVEAIARAAKSADDIYLATDPDREGEAISWHIAEILKERGLLKDKTMQRVVFTEITPR
AIKEAMLKPRAIAADLVDAQQARRALDYLVGFNLSPVLWRKVQRGLSAGRVQSPALRMIV
EREEEIEAFIAREYWSIDAHCRHPSQPFNARLIKLDGQKFEQFTVTDGDTAEAARLRIQQ
AAQGVLHVTDVASKERKRRPAPPFTTSTLQQEASRKLGFTTRKTMQVAQKLYEGVALGDE
GSVGLISYMRTDSVNLSQDALAEIRDVIARDFGTASLPDQPNAYTTKSKNAQEAHEAVRP
TSALRTPAQVARFLSDDERRLYELIWRRAVACQMIPATLNTVSVDLSAGSEHVFRASGTT
VVVAGFLAVYEEGKDTKSSEDEDEGRKLPLMKAGDNIPLDRIVTDQHFTQPPPRFTEAAL
VKALEEYGIGRPSTYASIIQTLQFRKYVEMEGRSFRPTDVGRAVSKFLSGHFTRYVDYDF
TANLEDDLDAVSRGEAEWIPLMEKFWGPFKELVEDKKDSLDKTDAGSVRVLGADPVSGKE
VSARIGRFGPMVQIGTVEDEDKPTFASLRPGQSIYSISIEDALELFKMPRALGQDKDQDV
SVGIGRFGPFARRGSVYASLKKEDDPYTIDLARAVFLIEEKEEIARNRVIKEFDGSDIQV
LNGRFGPYISDGKLNGKIPKDREPASLTFEEVQQLLADTGKPVRKGFGAKKATLKKNAVK
DSAKEAKDAAKKTAAVKKVATKTAAKKAPAKKAAKKATKRVVKKAVSKAAG
>Q8T2T7 ## E ## Eo ## Dictyostelium.discoideum ## DNA topoisomerase III (EC 5.99 ## Dictyostelium discoideum (Slime mold) ## DNA topoisomerase III (EC 5.99.1.2). ## Eukaryota; Mycetozoa; Dictyosteliida; Dictyostelium.
MTKRILNVAEKPSAAKEIAAILSNKRATVREGFSKYNKLWDFKYNILNFNDCEMTFTSVT
GHLMEIDVVEQFKPWASCDPIQLFDAPIRKTVPSDKEPLKKTLEREIKKADILILWLDCD
REGENIAFEVLEVCKNAKKKFEFYRAHFSAIIPREIDRACKNLAKPNEKDSIAVDTRMEI
DLRIGAAFTRFQTLYLKKFKIISNSDNQPKTTTPANGNILNNSNNNSSGKEIISYGPCQF
PTLGFVVERYFRIVNFKPEDFWHLSVVHEKMDTSSGKMIPVTFSWCRNRLFDYTAAFILY
EKCLDNTEATVVDVTSKESRYRPVPLTTIELQKAASKKLRISSVQTMQYAEELYTKGLIS
YPRTETDSFQAGTDLKGLIGNQASNPEWGAYASRLINNNQFVYPKSGKNNDNSHPPIHPT
SSATGLSGNLKKIYDFITRRFLACCSEESVFANTTVTIDIQGERFSETGTMVLKLGYLEV
YPFDKRNDKLIPTYQKGERFTPKRIDLTKGTTVAPHYITEAELLTAMDNNKIGTDATMAT
HIQTIQDRFYVKKNESNQFVPSNLGVSLVASYELMGFEFSKPNLRAAIEADVDKISRGQK
TKQEVLLSTIEKYKQLYQLANQNINCFDRSFREYYEPADPKGGEFRVLVSQFSRCGKCNG
KMQYKSDQNPEAPKRILFCPQCIDTFDLPKNGDISQLVTSMGVPQNCPICQYQVLSVRNP
INDKSYTICPKCRNSPPDPIHKKPFHCFQCTFNCNLATGNKQQQQQQQQQQQQTNYNRNN
NNNNTNSARPITTRTTRTTTQHRTFTASNNNFNNNNRNSDRNNNNFIF
>AAS82273 ## B ## Bo ## Thermus.thermophilus ## DNA topoisomerase I (EC 5.99.1 ## Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
MPKSAKRRASQPTGAETLVVVESPAKARSIQKMLGPGYEVRASLGHVVDLPERSLGVDVE
RDFAPTYEVKKDKKPVVEELKRAAEGKRLLIATDPDREGEAIGWHVARLLGRDPKEPLRV
EFHEITPRVVRQAVEAPRPIDQNLVDAQQARRVLDRLLGYNLSPLLSLEFRKRALSAGRV
QSVALRLVVEREEAIEAFRPEEYWVLRGVFAVEGGEAPLVATLHEVEGKRLWTGQGEKEG
RLHLASEAEAHALAEALRKGSYRVAQVEVRERRKAPPPPFTTSTLQQAASSRLGYTAART
MRIAQRLYEGVDLPEGTVGLITYMRTDSVRVAPEAVAAAREVIGKAFGPEYLPEAPRAYK
NRREGVQDAHEAIRPTDPQRTPESVRPYLSEEEYRLYELIWRRFLASQMRDALYEQTAVT
LADLEGRYAFRASGSVLRFEGYLRAWGRDAEEEEEPPVPAVPEGVPARLEEVLEERRFTE
PPPRYTDASLVKTMEELGIGRPSTYAPTLETLEKRGYVARKGRTLFPTPLGRQVTAYLRE
RFPQVVAYEFTARMEERLDEVEEGRVPWPKVVWEFYEPFLGELAQVPKKTCPECGRPLEL
KVSRYGQFLGCTGYPECTYTEPLERREAEPIGEACPKCGRPLLRKEGRYGAFIACSGYPE
CDYTRDDGTPTGHTCPKCGGRVLEKRSRKGRPYYKCENNACDFLSFYPLLEEACPACGWP
LVKKGEKALCLNPACPEHEPSLLPAPKEAKKGRSRGKGKPPLAPPKDWEELVPFLPGLSP
EERRAVEALARGEALAEEEARLARRALFKLRMRKGKARKEPVRA
>CAF30512 ## A ## Ae ## Methanococcus.maripaludis ## DNA topoisomerase I (EC 5.99.1 ## Methanococcus maripaludis ## DNA topoisomerase I (EC 5.99.1.2). ## Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanococcaceae; Methanococcus.
MTGLIICEKPNVAKKIAEALGKPKKKSHNSVPYYELERNGESIVVASAVGHLYTLQEKTK
TKFGDYPVYDINWVPASTLDEKKYIQKYIDALKKVSKDANKFYVATDWDIEGELIGYHAL
NFSCGQKNAHRLRFSSLTKKEILKAYENPNEIDFGLVDAGDSRHKIDWYFGINVSRALMQ
AVSSVKRWKTLSTGRVQGPALAFLVDKELEIRNFVPTPYWVLEALLDNDLIAVHELEKFW
DEEQANKAYEKVKGQKQATVSDVKKSMKTIPPNPPFDLGALQREAHNMFRFSPKKTQEVA
QKLYEKGYCSYPRTSSQKLPDDKAYMDEVLKNLSKNKNYKPYIETILNENRKPISGKNDD
PAHPAVHAVDVPKEKLPDDELKLYELIARRTIALYWDNAKREYSKINLDINGETFKLSGS
RTVEEGWHEIYYYTKFDEVELPELKKNDVINVNNINFEAKETKPPKRYTMASIIKELEKR
KLGTKATRADILEKLTKRGYVIEDGSLTVTDLGIGVTETLRKYCPEIVEETLTRDLEDKL
ELIQDKKIKKEEVIQETKDKLTKILGEFRLKEKEIGTELVDKLDSTNRSLQIIGKCKCGG
DMIIIRTKGKKRFVGCSNYPDCEVTFPLPQKGRIKVLNEVCEKCQNPVIGLDRIKICVNP
DCSTRISEEDKKEIEKAEKEEKICPKCGNKLLIKKGPYGVFRGCENYPKCKYTEKLNGES
NEKEIVGKCPKCGSDLYKRKGRFGEFIGCSNYPKCRHTEKIDKKKEDTPGETKAETKKEA
KPKTTKKAAPKKTATKTTKTTAKKTATKKTTTKKATAKKTAEK
>AAS14784 ## B ## Bp ## Wolbachia.pipientis ## DNA topoisomerase I (EC 5.99.1 ## Wolbachia pipientis wMel ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Wolbachieae; Wolbachia.
MALLIVESPAKAKTIGKYLSKEFKVAASFGHVRDLPAKNGSVDPDNDFTIKYETIEKAEK
YIKELVKAASKTSDIYLATDPDREGEAMAWHVIETLKEKKAISNENNIYRVVFNEITKRA
VQEAIKNPREINMDLVRAQQARRALDYLVGFSLSPLLWTKLSGSKSAGRVQSVALKIICE
REDEISKFITQEYWSIKAEMQNSKDEAFFAMLSHYDNKKLEKFDIKNEEEAKNLVREIES
RQYAVSTVERKQVKRNPLPPFITSSLQQDAVNKLYFNVKSVMRIAQNLYEGIDIGGETVG
LITYMRTDGFHIADEAINSIRGSIKSLYGDKYLPQSPRKYVKKVKNAQEAHEAIRPTDIN
RTPGSIKDYLTPEQFKLYDLIWKRTIASQMESAILDQVVVEISSTDQKVILRASGSSIFF
DGFYRVYQDNIEAENEGLLPAMKEGEACKLISVEPKQHFTQPPPRYSEASIVKKMEEIGI
GRPSTYATIISVLQDREYVSLDSKRFIPSSRGKIVTIFLETFFQRCVEYDFTAQMEEKLD
LISNGHADWKKELGHFWVPFFGHVNSVKQMTHDEVFSGIHDLVIDWFCSEEGRKEVNTKC
PACLGGILKLNFGKAGVFLGCSNYPECNHTKEITGSNDNSEYPKSLGIDDITNQEVMIKK
GPFGLYLEFNNELKKKKTVSIPKDINVNEIDLSTATQLLSLPKVIGEHPETGKEVKIGLG
RFGYYIFYDGRYFSLKKSSKEVLNTELSEAVQIIANSPRKELKSLGVNEKGKEVFICNGR
YGFYIKCGKTNVALGKSADIESIDLEKALELIKGKK
>Q8KGB3 ## B ## Bo ## Chlorobium.tepidum ## DNA topoisomerase I. ## Chlorobium tepidum ## DNA topoisomerase I. ## Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobium.
MASKSATPSARNRTLIVVESPSKAKTINKYLGDDYTVYASVGHIKDLPKKEIGIDFDNHY
EPRYEVIAGKEKVVRQLKKLAGEADKVLIATDPDREGEAIAWHISNEIDFAKKPVFRVLF
NEITRNAIIEAIGHPQQIDYRLVRSQQTRQALDKIVGYKISPFLWNVVYRGLSAGRVQSV
VLRLICERETEIEAFTPQEYWTIYADFTTENGETFRTKLVKVNGEKPDITSGEQAEAIAS
AIQGRLFAISEIVPKVIQRKQPLPFTTSLLQQAASNQLGFGSQKTMRTAQQLYEGIDLGS
EGATGLITYMRTDSTRISGEAVAQAHDYISQQFGPEYKGFGGQGKAGKNAQDAHEAIRPT
SVTRTPESLRRHLTPDQFRLYELIWKRFVASMMAPAKIEQTRVDVDDQKKEFVFRATGNK
VLFPGFFRVYDDQQELDYEAQKSTREELEKEQIVKLPERLSVDEQLKLAELDRRQSFTRP
PARYTEASLVKELDNYGIGRPSTYASIFSTLQDRRYVELQKKKIIPTELGRDVSAILVAN
FPDLFNVRFTAEMEDELDKVASGDDEYEKVLDRFYRPLESVLSHRKSDPLIPQNRDAVLC
EKCGKGHMIVKWTTSGKFLGCSNYPKCKNIKAITTNKAKPKETGVRCPVCGEGHMLLRNG
RLGPFLACSNYPKCNTLLNLSKQRHIEPIKTPPITTDLACPKCGAPMYLRTGKRGLWLGC
SKFPKCRGRLSWSTLDPETQARWEKAMNEHMAAHPSLAITMLDGKPAPMNLPIEDIIARA
EDAGLISATSEQPEAEATT
>Q7MW85 ## B ## Bo ## Porphyromonas.gingivalis ## DNA topoisomerase I. ## Porphyromonas gingivalis (Bacteroides gingivalis) ## DNA topoisomerase I. ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Porphyromonadaceae; Porphyromonas.
MKNLVIVESPAKAKTIGRFLGSDYTVLSSYGHIRDLKPNKFSVDIQNNYEPEYEIPADKR
PVVKELKSQADRSDFIWLASDEDREGEAIAWHLYEALGLKNKQTKRIVFHEITETAIRAA
IENPRDIDINLVDAQQARRVLDRIVGFELSPVLWRRIRPSLSAGRVQSVALRLIVERERE
INAFVPEASFRCTIEFVLPDGRMLTAELQKRFKTKEEARYFLEQCMDAHFHITDVTKRPG
KRSPATPFTTSTLQQEAARKLGYGVAQTMRIAQKLYEEGLITYMRTDSVNLSDMALGALK
KEITEHWGEQYYRFRRYKTKTKGAQEAHEAIRPTYIHRAEIDGTPQEQKLYQLIRRRTIA
SQMADAILEKTTITIGTDKFAETLSSQGEVIVFDGFLGVYREDSDEEHGSANTEEQLLPS
VKAGDTLSLHHAKATESFTQRPARYTEASLVRKMEELGIGRPSTYAPTIQTIQNREYVVR
GDKPGKTREYILLEYHKGKAITETIKTELNGQDRNKLLPTDMGLVVNDFLVASFPQVIDY
NFTAKVEKEFDQIAEGKLQWQKQIGRFYNKFHPLVAEACEFDPDQKIGERMLGTDPVTGE
SVVAKMGRYGAMVQKGRTDKENGIKAQFASLQPGQSIESITLEEALELFLLPKKLGQYED
ADVMVAVGRFGPYIKHAGKFVGLPKDTEPLSVSLDDAIKYIADKREKEEKSLIKGFAEDP
EMEIRTGRFGVYIKYKGKNYKVPKTVEDPEKLTLEECLKYVEEGETKPAKGKKKAPAKKT
SAKKTAKK
>Q8A3X7 ## B ## Bo ## Bacteroides.thetaiotaomicron ## DNA topoisomerase I. ## Bacteroides thetaiotaomicron ## DNA topoisomerase I. ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Bacteroidaceae; Bacteroides.
MQKNLVIVESPAKAKTIEKFLGKDFKVLSSYGHIRDLKKKEFSIDVDKNFKPDYEIPADK
KALVSTLKAEAKEAETVWLASDEDREGEAIAWHLYEVLKLKPENTKRIVFHEITKGAILK
AIEQPRNIDLNLVNAQQARRILDRIVGFELSPVLWRKVKPSLSAGRVQSVAVRLIVERER
EIHAFKSEAAYRVIAIFLVPDTDGKLVEMKAELSRRIKTKEEAKAFLDACKGATFTIEDI
TTRPVKKTPPAPFTTSTLQQEAARKLGYTVAQTMMIAQRLYESGFITYMRTDSVNLSEYA
TASSKDAIIQMMGERYVHPRHFETKTKGAQEAHEAIRPTYMENQSIEGTAQEKKLYDLIW
KRTIASQMADAELEKTTATISISKSGDAFTAIGEVIKFDGFLRVYRESYDDENEQEDESR
LLPPLKKGQKLEYGPIVATERFTQRPPRYTEASLVRKLEELGIGRPSTYAPTISTIQQRE
YVEKGNKDGEERTFNVLTLKDNQIKDESHNEVTGAEKSKLFPTDTGTVVNDFLTEYFPDI
LDYNFTASVEKEFDEIAEGEVKWTSIMKTFYDQFHPAVEKTLSIKTEHKVGERMLGEEPE
TGKPVSVKIGRFGPVVQIGAADDEEKPRFAQMKKGQSMETITLEEALELFKLPRTLGEYE
GKTVTVGIGRFGPYIQHNKVYVSLPKTLDPMKVTLEEAEQLILEKRTKEAERHIKKFDEE
PELEILNGRYGPYIAYKGNNYKIPKDIVPQDLSLKSCFDLIKIQDEKGPGTSAKGKRTAK
KK
>Q7PBH0 ## B ## Bp ## Rickettsia.sibirica ## DNA topoisomerase I. ## Rickettsia sibirica ## DNA topoisomerase I. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia.
MKLVIVESPAKAKTINKYLGDEFKVIASFGHIRDLPSKKGSVLPDENFAMKYDISDKAGK
YVDAIVKDAKKADAVYLATDPDREGESISWHVAEVIKEKNQVKSDDFFKRIAFNEITKKA
IIHAVENPRKLDTNLVNAQQARRALDYLVGFTLSPLLWRKLPGCKSAGRVQSVALRLICE
REDEIERFKSEEYWDISLKMQNSNNELFTAKLTHVNDQKLEKFSIINEKNAKDLTKKLKS
QKFHVDKIEKKQQKRQPQPPFITSSLQQEAARKLGFSAKKTMQIAQKLYEGVDIGKETIG
LITYMRTDGVTLSNDAIADIRRLIDKSYGDKYLPTSPRIYKSKVKNAQEAHEAIRPTNIT
YTPDSLKEKLDKDYYKLYELIWKRTIACQMENVIMDLVVANLASENKEYLAKANGSTIAF
DGFYKVYRESMDDEAEEENKMLPPLKEQELLKTKEVIPNQHFTEPPPRYSEASLVKKLEE
LGIGRPSTYASILSVLQDRKYVALEKKRFIPEELGRLVTVFLVGFFKKYVEYDFTAGLEN
ELDAIAAGKLEWKAALNNFWSGFNHNIESVNEQKITEIISYVQKALDYHLFGENKESKIC
PSCNTGELSLKLGKFGAFLACSNYPECTFRKSIVSGNDNNENEGEPAAMPNENKVLGTDK
DGVEIYLKKGPYGPYIQLGKQEGKVKPKRSPVPASLNQNDITLDIALKLLSLPLKIGIHK
DSDEEIMIGYGKFGPYIKYMDQFISVQKKYDFLNLSLDDAMKLIEENKAKLEKKQA
>Q97CT2 ## A ## Ae ## Thermoplasma.volcanium ## DNA topoisomerase 1. ## Thermoplasma volcanium ## DNA topoisomerase 1. ## Archaea; Euryarchaeota; Thermoplasmata; Thermoplasmatales; Thermoplasmataceae; Thermoplasma.
MQDYFRVIIAEKVDAGRRIAYFLSNGTAKARRVKGLSYIEFESNGKKTLLIPLSGHIVEA
DFPENFSNWEKTDLKELIDADIVKKVKNKSAYQTLSSFKGKADEIIIATDYDREGELIGV
EALDIIKEGQEKVLRAKFSSLVGQEIRNAFEKPIDVNYNLADAADARESIDLIWGAVLTR
FFSLATGRLGRYFLSAGRVQTPTLAIVVEREREIENFKPQTFWTISITFQKEGEFQAAYE
KKLFDKDVANSVFSSINGRDGTVIKFEKHEESIRRPTPFSTTEFLREASRIGIMPTKAMS
IAESLYTRGLISYPRTDNTVYPRAINLRNVLQKFSKSKYSNYVEEILGWEKIIPSRGRTE
TTDHPPIYPVEMPKEELKGDYARIYDLILRRFISTLYRDGRKTVKEAEIDVNGYKFLARG
SQTTDLGWMAVYGYSSRDEFMPDLSEGEILHGTNWLLNEDQTKPPPRYDMASLLKKMEDL
NLGTKSTRHDIIGKLIDRGFIEGNPVRPTGLGIAFIDAVKSVNSSIADPDMTAKLEQDMD
KIERSLMSKQEVVDESKKMLHSVLGDFINKADDVKSIINTGINAGEAMGKCPFHPDHNLI
LSKDKFTYRIRCEVDGCRIDFKIKKNGSISLMDQLCPVCGLPLIKIIRRGQSPEVKCIDP
GCAYNKEKEDFGECPKDGGRLILRQSRYGKRFLGCSNYPKCTVTYPLPQKGKIEKTGEKC
PICGAPLLEAVNGKRRWKFCPNISCEYNKKKSNKVEEKKAGRRKKDASKS
>TOP1_THEAC ## A ## Ae ## Thermoplasma.acidophilum ## DNA topoisomerase I (EC 5.99.1 ## Thermoplasma acidophilum ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Archaea; Euryarchaeota; Thermoplasmata; Thermoplasmatales; Thermoplasmataceae; Thermoplasma.
MDGFRIIIAEKADAGRRIAYFLSGGQVKSHRAKGTSYLEFEYNGSKTYLIPLSGHIVEAD
FESGYSDWNKIDLSDLIDARIVKNIKNKVAYQTLQAFRGKVEEIVIATDYDREGELIGVE
ALDIIKEGKEEIRRAKFSALTKNEILDSFKNLIGVNYSLADAADARESIDLIWGSVLTRF
FSVTTGRLGKSFLSAGRVQTPTLAIVVDREREIQSFRPERYWTISITFDKDGQFKARYPE
NIKDQDTAEKIYEAIKGKNGRVSSYTSKEDHIRRPAPFSTTEFLREASRIGIMPTKAMSI
AENLYMRGLISYPRTDNTVYPRSINLKSVLKKLENTAYSKYVKEIETFDRILPSRGRIET
TDHPPIYPVDSPKEQLKGDYGRVYDLILRHFLSTLYRDGKKTVAEAEIYVNGYTFKAAGQ
HTTDRGWTEIYGYDPKDVYLPELTEGEDLKAIDWNIQREETKPPPRYDMSSLLKKMEELN
LGTKSTRHDIIGKLIERGFIEGNPVKPTPLGMAFIDAVRSVNSHIADPEMTAKLEEDMDR
IEKNEMSKNDVVEESKKMLHEVLSHFLTKTADVKDIITKGINAGQEIGDCPFHEGKKIMV
IRDRFTYTVRCEDPSCKINFRIKRNGSITLSDQKCPVCGLPMIKIIRKGQSPEIKCIDPD
CSYNRENEDYGECPADHGRLVLRQSKYGKRFLGCSNYPKCTVTYPLPQMGRITKTGEVCP
YCGAPILALSRNGRKWKFCPNMQCEYNKKRKPEAAVEKSVRKKGRNASKS
>Q7NGH1 ## B ## Bo ## Gloeobacter.violaceus ## DNA topoisomerase I. ## Gloeobacter violaceus ## DNA topoisomerase I. ## Bacteria; Cyanobacteria; Chroococcales; Gloeobacter.
MSKSLVIVESPAKAKTISKILGKNFVVKASAGHIRDLPQKEMGVNVKNDFEPKYVIIPKK
EEVVEELKGAARNADRVYLAPDPDREGEAIAWHLAQILDIPGDRLQRIEFHEITKQAIQN
AVAHPRDIDINRVDAQQARRILDRLVGYKLSPLLWKKVQRGLSAGRVQSVAVRLLCDREK
EIQAFVSEEYWTVHGRFRQSAQVEATPFSADLVRWSGKKPDLGNETAARAVVEVLTGAAS
RVDSVKTRERQKEPQPPFITSTLQREGASALGLTVKRTMAIAQQLYEGIDLGEEGPVGLI
TYMRTDSTRVAEEAQEAAREFILAAYGKSYYPSRRRQYGAKKGAQDAHECVRPTDINRPP
DAIKKSLTPDQFKLYRLIWQRFTASQMTAATLETRTVEIAATPTAGRPDALFRVSVTRTI
FDGYTRVYEEAREEAATGDEEAAGAAPVLEEGEALTLLTVDPKQHFTQPPARFSEATLVK
ALEEQGIGRPSTYAPTIGTIQERGYVNKDGRTLIPTDLGMKVNDQLVQHFPNIVDTEFTA
NMEAQLDEVEKGSQRWTQLLADFYGPFVETLKAADEEMKRVVIVTDHLCESCGRPLLNRY
GRFGNFLGCSGYPECDFTHQLTRDNKPVPKDRPAEGISCNQCGHAPMLITYGRYGEYLKC
PACGKSQPKSTGITCPKCSKGQIVERRSKMGKNFYGCDQYPDCDFVLWSRPIDKPACPEC
GSILLYKPRKRGDDMVACSACKFTAPAQEMVGEEEVERQAELLTG
>Q83AA5 ## B ## Bp ## Coxiella.burnetii ## DNA topoisomerase I. ## Coxiella burnetii ## DNA topoisomerase I. ## Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales; Coxiellaceae; Coxiella.
MVKSLVVVESPAKAKTIEKYLGKDFKVMASYGHVRDLIPKEGAVDPEDHFKMHYQAIERN
IRHMDAIAKALKPCHNLYLATDPDREGEAIAWHVKQMLESRNGLKDKKFSRVVFHQITKK
AVQHAIENPRDISMDLVNAQQARRALDYLVGFNLSPLLWKKIRPGLSAGRVQSPALRLIV
EREIEIENFESQEYWTIHADCHAQQQPFDARLIEFQGEKLEQFSIVNEKQAHETRDAITQ
AANGKLTVAKVVKRERKRNPAPPFITSTMQQEAARKLGFSASKTMQIAQQLYEGVNLGEE
GAMGLITYMRTDSVTLASEALQEIRQLIEEKYGQENVPEQTRIYKTKSKNAQEAHEAIRP
TSAFRTPENLKKYLNSDQLKLYTLIWKRTIACQMIEATLHTVAVDLKAPNAIFRANGSTI
VKPGFISVYQETFDDKKKEEESDSKMLPPLEEGQTVDVNEIKSEQHFTEPPPRYTEASLV
KALEEYDIGRPSTYASIIATLKNRKYVDVDNKRFIATDVGRIVNRFLTHYFTKYVDYGFT
AKLEDELDDIARGEKTWIPVLETFWSPFKNLVDVTEKTVKRSDVTQEKIDEKCPKCSAQL
SIRLGRRGRFIGCTAYPDCDYTRNLTEIAAEAQAVLEGRQCPECQSNLIIKMGRYGKFIG
CSGYPNCKYMEPLEKPKDTNVTCPKCKKGTILQRKSRRGKIFYSCARYPDCDYALWNEPV
AEACPKCGWPILSIKTTKSRGTEKVCPQKSCNFIEAYDGDKPSLD
>TOP1_METJA ## A ## Ae ## Methanococcus.jannaschii ## DNA topoisomerase I (EC 5.99.1 ## Methanococcus jannaschii ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Archaea; Euryarchaeota; Methanococci; Methanococcales; Methanocaldococcaceae; Methanocaldococcus.
MAEIMTALIICEKPSVAKKIANALGKAKKKSIDGVPYYELERDGKKIIVASAVGHLFTLV
EKENKEFGFYPVFDIKWVPASVDKGKEYVNKYIKALKKLSKDADEFYIATDWDIEGELIG
YHALKYCCGREKAKRMRFSSLTKKEIVRAFENPDEIDYGLVDAGESRHILDWYFGINLSR
ALMNAIRAVNRWKTMSVGRVQGPALAFLTERELEIKKFIPKPYWVIEALLKDNLKAIHEK
EKFWNEKEAKNVYEKIKDEKSAKVVEIKKTKRKLKPLPPFDLGTLQREAYSYFKISPKET
QEIAQKLYENALISYPRTSSQKLPKDRKYLEDILNIIKNHPVYGKWAERILKENLKPVEG
KKEDPAHPAIHIVDIPKEELSEKEKEIYDLIARRTLAAFWDNAEREYLNVKIDIKGEKFK
LSGSRTVKEGWHEIYYFPKFDEIELPPLKKNDIIKVEKITITRKETQPPKRYTVASIIKE
LEKRGLGTKATRAEIIDKLIKRGYVIDDGSLKVTDLGISVIETLKRFCPEIIDEKMTRDL
EEKLEKIQFRKIKKDDVLDEAEKRLRKILEEFKKKEEDIGIYLIKNLDATNKKAKIVGKC
PKCGGDLILIRHKKGRFVGCSNYPECDVKYSLPDKGRIKIPNKVCDACKSPILKIGDREI
CINPECPLKQVEVKEEDRICPKCGAKLILKKGVYGAFYGCSNYPKCKYTEPINKKEVVGK
CPKCGGDLVVREGKFGKFVGCSNYPKCRYTEKLKLNEKEEK
>AAS97858 ## B ## Bp ## Desulfovibrio.vulgaris ## DNA topoisomerase I (EC 5.99.1 ## Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303) ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales; Desulfovibrionaceae; Desulfovibrio.
MGKDLIIVESPAKVKTIKKFLGGKYVVQASVGHVRDLPTNEIGVDEANNFAPQYRVIDGK
QKVVDTLREAAAKADTVYLAPDPDREGEAIAWHVAALIEGKADNIKRIQFNEITARAVRE
ALENPRDLNRALFDAQQARRVLDRLVGYKLSPLLWKKVKRGISAGRVQSVALRLIVDRES
ERRAFTPEEYWLFRAMFAKNVPGATPTSPDPQYAPFKAELAKIDGKKAHVADADAANALE
DAMRGKPFVITAVERKKRERQPQPPFITSTLQQAANQRLGYSAKRTMNIAQRLYEGVELG
EMGTVALITYMRTDSVRVSDEARDAARAFVTETWGADFCPAKPRQFKTKGSAQDAHEAVR
PVDVNVTPDSVKHLLPPDQFQLYRLVWSRFVASQMAPARFDDTTVAIACGPAEWRAKGER
MLFPGFLAAMPQKEEGDAELPPLQEGETLHPVSVEKEQKFTQPPARYTEASLVRELEERG
IGRPSTYASIISTLIDRDYTRLEDKHFVPTDLGATVCDLLARHFTTLMDVGFTAQMEDSL
DKVAEGGLDWVELLSRFSADFNPTLESAAKAMETVKGGLPTDVTCPECGKPVVVKFGKAG
PFLACTAYPDCKFTSNFSRDEKGDIVIEQRAREELEAVGTCPECGKDLVVKKARTGSRFI
ACTGYPDCRHTEPFSTGIACPREGCDGQLVEKSSKRGKIFYSCNRFPKCDYALWDWPVPG
PCPVCGSPLLVKKSTRAKGLHIACPEKTCRYTQELPDDEG
>TOP3_CAEEL ## E ## Em ## Caenorhabditis.elegans ## DNA topoisomerase III (EC 5.99 ## Caenorhabditis elegans ## DNA topoisomerase III (EC 5.99.1.2). ## Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
MKRALFVAEKNDVAKGVAAILSNGTANRREGRSKFNKIYTLNTELFGQQTAISVTSVSGH
MMNFQFHENMSNWQTASMVELFRAPVRHVVTPEMKLIEQTLREQAQRHDILVVWTDCDRE
GEAIGAEIVKVCRDSNRRLDIFRARFSEITKAAITRAARNLIRLDEKTVAAVDCRSELDL
RIGSAFTRLQTLHLRNRFRDLLGQNDTSQVISYGSCQFPTLGFVTDRYKMIENFVSEPFW
KLIVEHTRESHKVEFLWDRNRLFDRDTVDILHDECKETKEAHVEKVAKKPKSKWRPQALD
TVELEKLGISKLRMSAKQTMQVAEKLYSKGFISYPRTETNKFPAGLNLTPLVQQQTQSNI
WGDFANEVLQNGVNPRNGRKSDEAHPPIHPLKFTEKHQLQGDDWKVYELVVRHFLACVSQ
DAQGEETMVNLTVGTEKFHASGLRIRDMGYLKVYVYEKWGNRLLPTYTEGERFTDFELKI
GDGKTQAPDFLTEADLISLMDKYGIGTDATHAEHIEKIKTREYIGVRPDGKLIPSFLGLA
LVDGYDDMGFAMSKPDLRANLEIGLKEICDGRRQKQEVLDEQIGKYRAIFVESERKIGVL
SQSLQRYLDKNNQAGGGPGGPGGGGGPPRGPGGGGGGGPTGPPAPPKPPAKPRGRPPRKS
ISPAVKNGHDDPENDTIVTLSEVFGSMSNPKPARKPRAPRKSAAPKEQEEEEEVFCQCPE
PMRAVTKVVQKEGPNKGKKFYTCSLPYTSSEKCNFFKWA
>AAR35922 ## B ## Bp ## Geobacter.sulfurreducens ## DNA topoisomerase I (EC 5.99.1 ## Geobacter sulfurreducens ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales; Geobacteraceae; Geobacter.
MSQHLVIVESPAKAKTIEKFLGPDYKVLASYGHVRALPSKQGSVDVEHDFEPRYAVLPES
KRHIDAIKKELKASDSLLLATDPDREGEAISWHLLAALGVKPEKPPVPVRRVVFHEITKD
AIVHAVENPRDISQDLVDAQQARSILDYLVGFNLSPFLWKKIRYGLSAGRVQSVALRLIC
EREKEIQAFQSQEYWTIGAELAKEGGQKCTANLVEAEGKKLDKFDIPDQAAADRLVKALE
NATFTVDKVTKSERKRTPAPPFTTSTLQQEAARKLGFSAKKTMATAQKLYEGVAIDEGLV
GLITYMRTDSVVLSNQALQEAHQVITSLYGPEYALAKPRFYKNKAKNAQEAHEAVRPTSI
ARTPAELKKYLSSDQFKLYDLIWKRTVACQMAEALLDQTSVDIGAGKGYRFRAAGTVIRF
PGFMKLYIEGVDDQAEEKEGTLPPLTEGELLKLLKLLPEQHFTQPPPRYTEASLVKTLEE
YGIGRPSTYASIMNTLLERKYARLDSKRFIPEDVGMVVNDLLTNHFTTYVDYNFTATLEE
ELDQVSRGEKRWKPLLREFWEPFQGLLKQKEGEVSKADLTTEATDEACPECGKPLVVKLG
KRGKFIACSGYKEGCTYTRNIDQGEGREQAEPVLSEEKCDKCGSPMLIKDGRFGKYLACS
AYPACKNIQPLVKPKGTGHTCPECKEGELTEKKSRYGKMFYSCNRYPQCKFALWDPPQPG
PCPKCGFPLLVKKVYKREGEFLKCPKEGCDYRTEGKK
>Q7P6B1 ## B ## Bo ## Fusobacterium.nucleatum ## DNA topoisomerase I (EC 5.99.1 ## Fusobacterium nucleatum subsp. vincentii ATCC 49256 ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Fusobacteria; Fusobacterales; Fusobacteriaceae; Fusobacterium; Fusobacterium nucleatum.
MLELPKKSEKNKLVIVESPAKAKTIEKILGKSYKVISSYGHIIDLPKTKIGVDVNNDFKP
SYHTIKGKGEVIKQLKEASKKADKIYLASDPDREGESIAWHIANTLKLDHNEKNRIEFHE
ITEKAIKDAVKNPRKINIAKVNSQQARRILDRLVGYEISPFLWKLISPNTSAGRVQSVAL
KIICELEDKIKAFVPEKYWDVKGIFDSKYNLNLYKIDNEKIEKLKDEKLLDRVKKDLKKK
YEVISSKVSKKIKNPPLPLKTSTLQQLASSYLGFSASKTMSVAQKLYEGISIKGEHKGLI
TYMRTDSTRISEEAKEMARNYIIKEYGKEYLGSASPKTKKESKNVQDAHEGVRPTDINLT
PQNVMQYLDKDQFKLYNLIWQRFLISQLAAMKYEQFEYILEKDKIQYRGSINKIIFDGYY
KVFKEDEDLPIGDFPKIKEGDKFTLNKLDIKEDYTKPPARLTESSLVKTLEAEGIGRPST
YASIIDTLKKREYVELQNKSFVPTEIGYEVKTQLDKFFPNIMNIKFTAKLEDELDEVDSG
DKNWIDLLKVFYTELQKYEEKCKSVVEEELEKLVVSDVLDKNGKPMIMKIGRFGRYLASQ
DTENKENISLKGIDISLEDIKKEKIFVKKQIEELSKKKEGQKTDIILDNGSRLLLKYGRF
GAYLESENYKEDNIRKTIPKEIKTKIDNNTIKKENDILCLKDMFDKIEKEEAEILKKAGK
CEKCGRPFKIKNGRWGKFLACTGYPECKNIKKISKDK
>Q8PSK3 ## A ## Ae ## Methanosarcina.mazei ## DNA topoisomerase I (EC 5.99.1 ## Methanosarcina mazei (Methanosarcina frisia) ## DNA topoisomerase I (EC 5.99.1.2). ## Archaea; Euryarchaeota; Euryarchaeota orders incertae sedis; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
MHLIVTEKNIAARRIAAILAPKSPKKERVSGVDVYRYEIGSGENRQETAVVGLSGHIVGI
DFPKEYNNWQKVDARDLIDAEITTTPINRKIVTALKSLGKEADRVTIATDYDREGELIGV
EALNIIKKVNPKIPFDRVRYSAITPKAIEAAFSNPTNVDFNLADAGHSRQVIDLVWGAAL
TRYISLAAGRLGKMFLSVGRVQSPTLSLIVDREKERNIFVPTPYWEIHVELEDAAGETFS
AQHSTRRFLDKEEASKVFRKLGKKAELKEIEKGTKTDQPPTPFNTTGFISAANSIGLSPA
NAMRIAESLYTNGYISYPRTDNTVYPDTLDLKAQIEIFKEGPFKEYANTLLEKPELVPTR
GKKETTDHPPIFPASLAKESDLKEDEWKVYELVVRRFFATFAGPSIWETMRLKLDIEGEE
FRANGARLLEPGWRWYYPYNAPEDRLLPELKESDLLKVIKKEMLDKETQPPGRYGQGRLI
NIMEELGLGTKATRHEIISKLYSRAYIHGNPVQPTNTSFAVMDTLEKYSPTITKPDMTKL
LEENMDKIAEGKIKEEAVLEESREMLKQVFSELDKNRDNIIESLQAGLREDKIIGDCSLC
GNELMIRRSKRGSRFIGCSNYPNCTFSLPLPKSGQIIVTDKLCEAHGLHHIRIINQGKRA
WDLGCPQCNFIEWQKTQKEEQAQQPKKEKPKSIKDLEGVGKATAGKLEEAGITSVEALAE
ADPVELAKTIKTSVKKIKNWQTSCNGGAVEDL
>Q7VF79 ## B ## Bp ## Helicobacter.hepaticus ## DNA topoisomerase I (EC 5.99.1 ## Helicobacter hepaticus ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
MKDLIIVESPAKARTIKNFLGSKYEVIASKGHIRDLPKYTFGIDIKDKTFHPQYTISKDH
MEIVEKIKVASKKAKVTYIATDEDREGEAIGFHITQALNLPYEKIPRIVFHEITKNAITH
SLQNPRQIDMAKVNAQQARRLLDRIVGFKLSELISSKIQRGLSAGRVQSSALKIIVDRER
EIRAFKPTIYFLINAVFNMKPKSKQKNQDNGQNNIEAELITYDKKLEKLSLQNFEAVEAM
LEHIQKQQFFIKEIITKSKKISTPPPFMTSTLQQSASSLLGFSPSRTMSIAQRLYEGVET
NFGSMGVITYMRTDSLNIAKEAQKAAREMIIKTYGKEYVPAKTKNYATKSKAAQEAHEAI
RPTNLDFTPEIAKSYLKPEEHKLYALIYYRFLASQSQDALFEIQNIIFTPHNQTHLIEFK
ASGRKLVYDGFYKIMGNDDKDKLLPECKEGEDVLLNNIESVQKSTEAPSRYSEASIIKSM
ESLGIGRPSTYAPTIALLVAREYVNIEKKQLVPQESAFKVIEMLESYFDEIVDTHFTAGL
EDKLDEIAQAKMNWESVLWEFYQPFMQKIESGKKVIVSQKVAIPTGEMCPKCGKELVQRK
SKYGEFIACSGYPKCKYIKPTQQDSQSQSQEYGVCEKCGEPMIKKFGRNGEFIACSGYPK
CKNTKSLTDKAQAHSVEGVVCPECEGEIVKRFSRRGAFYGCKNYPKCTFISKFEPIKEKC
PQCGGISVEREYRKKQVRECLKCKHRIEI
>Q7M8P6 ## B ## Bp ## Wolinella.succinogenes ## DNA topoisomerase (EC 5.99.1.2 ## Wolinella succinogenes ## DNA topoisomerase (EC 5.99.1.2). ## Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Wolinella.
MKNLIIVESPTKAKTIKNFLGKEYEVIASKGHIRDLPKHNFGIKIEGQSFLPDYKIEKGH
EAVVKEIKALAQKAKTIYIATDEDREGEAIGYHISHAIDKDPTTLPRIVFHEITQNAIKH
ALETPRSINMDMVNAQQARRLLDRIVGYRLSPLISSKIQKGLSAGRVQSSALKLIVDRER
EIRSFVPVTYFTIEALFEKGIEAELIEFEGEKLEKLSIGESKKANEMVKVLQKESWSITG
IEHKRRKTSTPPPFMTSTLQQSASSVLGFSPSKTMMAAQKLYEGVMTHQGVMGVITYMRT
DSLNIAKEAQEAARSRIKEVYGERYLPKEPKVYTTKSKSAQEAHEAIRPTLIDFTPQLAA
QYLKGDELKLYSLIYNRFLASQMNDAEFELQTILLGSSKGVFKVSGRKLIFDGFYRVMGS
EDKDKLLPELQKGEALKLEECKANRHETEPPARFSEASIIKTLEALGIGRPSTYAPTISL
LAGRDYIRIEKKQIIPEEVAFKVIEVLEAHFTEIVDSHFTATLEEELDEIAESKKDWQKV
LWDFYEKFDAKIALGKKNIESQKVAIPTGEMCPKCGAELVRRMSRYGEFVACSGYPKCKY
IKPQESSPEQEGEESEEVCEKCGKPMVKKRGRNGEFLACSGYPDCKNTKSLKKSSTPKKV
LEVKCPKCGGEIIERSSRRGNFFGCANYPKCDFISSHEPINEKCQKCGGMMAKRTYRKKE
VHECIACKDRIEVEERNEEEK
>O53042 ## B ## Bp ## Helicobacter.pylori ## Topoisomerase I (EC 5.99.1.2)  ## Helicobacter pylori (Campylobacter pylori) ## Topoisomerase I (EC 5.99.1.2) (DNA topoisomerase). ## Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
MKHLIIVESPAKAKTIKNFLDKNYEVIASKGHVRDLSKFALGIKIDETGFTPNYVVDKDH
KELVKQIIELSKKASTTYIATDEDREGEAIGYHVACLIGGKLESYPRIVFHEITQNAILN
ALKTPRQIDMSKVNAQQARRFLDRIVGFKLSSLISSKITKGLSAGRVQSAALKLVIDRER
EIKAFKPLTYFTLDAYFEPNLEAQLISYKGNKLKAQELIDEKKAQEIKNELEKESYTISS
IVKKSKKSPTPPPFMTSTLQQSASSLLGFSPTKTMSIAQKLYEGVATPQGVMGVITYMRT
DSLNIAKEASEEARAKILKDYGKDYLPPKAKVYSSKNKNAQEAHEAIRPTSIILEPNALK
DYLKPEELKLYALIYKRFLASQMQDALFESQSVVVACEKGEFKASGRKLLFDGYYKILGN
DDKDKLLPNLKENDPIKLERLESNAHVTESPARYSEASLIKVLESLGIGRPSTYAPTISL
LQNRDYIKVEKKQISALESAFKVIEILEKHFEEIVDSKFSASLEEELDNIAQNKADYQQV
LKDFYYPFMDKIEAGKKNIISQKVHEKTGQSCPKCGGELVKKNSRYGEFIACNNYPKCKY
IKQTENANDEAKQELCEKCGGEMVQKFSRNGAFLACSNYPECKNTKSLKSTPNAKEVIEG
VKCPECGGDIALKRSRKGSFYGCNNYPKCNFLSNHKPINKRCEKCHYLMSERIYRKKKAH
ECIKCKERVFLEEDNG
>TOP1_TREPA ## B ## Bo ## Treponema.pallidum ## DNA topoisomerase I (EC 5.99.1 ## Treponema pallidum ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
MEVRGLQPKRQKTFARKHLVIVESPAKAQTIEKYLGTQYVVRASMGHVIDLPKSRLAIDI
EHDFQPEYITVRGRAQCLKELRTLSKQSLQVFLASDRDREGEAIAYHLAQSIQAYCDTPI
KRIVFNEITPHAIRAAIGHPVPIDTAKVNAQKARRVLDRLVGYHLCPLLWHKVKNGLSAG
RVQSVALRLICEREVEVKRFVPEEYWTVEGTFEKDKKSFSALLILIQGKKAVFKSKQEAT
SAIGLFSQSEARVSQIRSFEKNVRPKQPFTTSTLQQCAANRLGFTSRKTMQVAQQLYEGV
SLGTHRVGLITYMRTDSVRVSEAAVKEVRAWIATHFSDALPGTPNRYAAKGKSQDAHEAI
RPTYVAHTPERIKAHLTRDQIRLYTLIWERFVASQMTDARVRSLTFEITAGPAVFSATET
QVIEQGFYRVLKMLSPKDLSKAVLPPTKEGEVVALHNVQSVQHFTQGPVRYTDASIVKML
EEKGIGRPSTYAPTISVLLDRYYVTRIQKQLMPTPLGKVISDLLTTYFHDVVDVSFTARM
ESKLDEVEEDKIKWNCVIADFYPAFSEKVSTVMKDLNSMRGVFDEKTDVVCSQCGDTMVK
KLGRFGFFLACGKFPECRNTQPVPLAKCPRPACDGNIVGKKTRGRKEFYGCTRFPVCDFV
THFKPTFAVCPQCRCFLVEKSNRRVGTYTACVNPECRYVSPTRKNLSLGKEAVLDGSHRG
AQDKGAVQHYE
>Q898P2 ## B ## Bf ## Clostridium.tetani ## DNA topoisomerase I (EC 5.99.1 ## Clostridium tetani ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
MGKTLVLAEKPSVGREIARVLKCNKNSRSYIESNKYVVTWALGHLVTLADPEVYDNKYKK
WEMETLPMLPKYMKLCVIGKTSKQFNEVKKLMNRNDIDEIVIATDAGREGELVARWIIEK
ARVNKPIKRLWISSQTDKAIIDGFNNLKPGKDYENLYKSAVCRSEADWLVGLNVTRALTC
KYNAQLSAGRVQTPTLALIVEREEEIKNFKPRDYYNIVAKTKGIQFNWQDKKGQMATFNE
DFANNILAKVSGEIGNVTEVIEKDKKQYAPALYDLTELQRDANRIFGYSAKETLSIMQRL
YENHKVLTYPRTDSRYISKDIVATIPQRLKSISIGIYSKFAEEILRGKIVAHKGFVDDSK
VSDHHAIIPTEERVKLSNLSGDERKIYDLVIKRFLSVMLPPFEYIQTTIKVEVNGEVFIA
KGKNIKHNGWKAVYNKEDLNEDNNDGDGLKEQVLPQIIKGDAIKFNLVNINKGQTKPPAR
FNEGTLLSAMENPQKYIKLNKEYAKTLGETGGLGTVATRADIIEKLYNSFYIEKKGKEII
PTSKGKQIIDLVPQDLKSPILTAEWEKKLELISKGKISGKEFINNMRNYSTKLVQDVKNS
NEKYIHNNLTGTKCPNCEKYMLEVNGKRGKILVCQDRECGYRENISRFTNVRCPECHKKL
ELRGEGEGQIYVCSKCTFREKLSSFNKRFKEKGNNADKREVSRYMKKMKEQDKEPMNSAL
ADALAKLNLK
>AAS39420 ## B ## Bf ## Bacillus.cereus ## DNA topoisomerase III (EC 5.99 ## Bacillus cereus (strain ATCC 10987) ## DNA topoisomerase III (EC 5.99.1.2). ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
MSKSVVIAEKPSVARDIARVLKCDKKGNGYLEGSKYIVTWALGHLVTLADPESYDVKYKK
WNLEDLPMLPERLKLTVIKQTGKQFNAVKSQLLRKDVNEIIVATDAGREGELVARWIIDK
VRINKPIKRLWISSVTDKAIKDGFANLKPGRAYDNLYASAVARSEADWYIGLNATRALTT
RFNAQLNCGRVQTPTVAMIANREDEIKNFKAQTYYGIEAQTTNQLKLTWQDANGNSRSFN
KEKIDGIVKGLDKHNATVMEIDKKQKKSFSPGLYDLTELQRDANKKFGYSAKETLNIMQK
LYEQHKVLTYPRTDSRYISSDIVGTLPERLKACGVGEYRPLAHKVLQKPIKANKSFVDDS
KVSDHHAIIPTEGYVNFSAFTDKERKIYDLVVKRFLAVLFPAFEYEQLTLRTKVGNETFI
ARGKTILHAGWKEVYENRFEDDDVTDDVKEQLLPRIEKGDTLTVKLIMQTSGQTKAPARF
NEATLLSAMENPTKYMDTQNKQLADTLKSTGGLGTVATRADIIDKLFNSFLIEKRGKDIH
ITSKGRQLLDLVPEELKSPTLTGEWEQKLEAIAKGKLKKEVFISEMKNYTKEIVSEIKSS
DKKYKHDNISTKSCPDCGKPMLEVNGKKGKMLVCQDRECGHRKNVSRTTNARCPQCKKKL
ELRGEGAGQIFACKCGYREKLSKFQERRKKESGNKADKRDVQKYMKQQKKEEEPLNNPFA
EALKKLKFD
>Q8XK95 ## B ## Bf ## Clostridium.perfringens ## DNA topoisomerase III. ## Clostridium perfringens ## DNA topoisomerase III. ## Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
MKKLVLAEKPSVGREIAKVLKCNNNKGSYIEGKDYVITWALGHLVELQSPEDYDNKLKTW
SMETLPMLPKHMKLKVIKKATKQFYEVKKQMERKDIDEIIIATDAGREGELVARWIIEKA
HVKKPIKRLWISSQTDKAILDGFKNLKPGENYNNLYKAAQCRAEADWLVGLNVTRALTCK
YNAQLSAGRVQSPTLAMIVQREEDIKNFKPKEYSTILIETDKCNFTWINKDNNSRIFKND
FKEKVVSNLNEKKSGKIININESNKKKFSPQLYDLTELQRDCNKIFGYSAKQTLNIMQRL
YENHKLLTYPRTDSRYISKDIVSTIPDRLKAVATGEFRTIANDLLKNPIKANKSFVDDNK
VSDHHAIIPTEEKGNLANLSSDERRVYELVVKRFLSVLMPPFEYIQTTLTGEVNGEKLIA
KGKVVKAKGWKKLYDREVDDEGEEDIKEQELPKLKEGDEFKVLKVNVKKGETKPPARFNE
GTLLSAMENPQKFISVDKSSAKTLGETGGLGTVATRADIIEKLFNSFVIEKRGKEIIPTS
KGKQLIDLVPKDLKSPLLTANWEEMLERISKGKGDSKKFIKDIRNYTVALVEDVKLGESK
FHHDNLTGKKCPQCGKYMLEVKGKNGTMNVCQDRECGYRENISRITNARCPECKKKLELR
GHGEGKIYVCPGVNCNFREKESQFKKRFEKNNKTNKREVNKIMQKMKKEANEDVNNPFAD
LLSGLKFD
>Q97F08 ## B ## Bf ## Clostridium.acetobutylicum ## Topoisomerase B. ## Clostridium acetobutylicum ## Topoisomerase B. ## Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
MGKILVLAEKPSVARDLAKVLKANINKKTHLEGNKYVVIWALGHLVSLADPESYGEKYKK
WSMDTLPMLPKNMKLSVLKNTSKHFYDIKKVMERKDLDELVIATDAGREGELVARWIIEM
AKWKKPIKRLWISSQTDRAVRDGFAHLRDGRDYENLYKSAKCRSEADWFVGLNVTRALTC
KYNAQLSAGRVQTPTLYMIVSREEEIRKFKPKDYYTIEGKVKSFSMNWHDKSGDFKIFNK
ERAEKIEALVKGSKGKIVDVSESKKKKYSPALYDLTELQRDANRFFGFSAKETLSIMQRL
YENHKLLTYPRTDSRYIPHDVVATLPDRLRAISIGKYSKFAAEILRSKINVHKGFVDDSK
VTDHYAIIPTEERPALGALSNEEFKIYDLVVKRFLSIMLPPFEYIQTTVKAEVAGEIFIA
KGKVVKSKGWKEVYDKTEDFEEKSELKDQMLPEMNKGEDITFSTVSIKKGQTKPPSRFTE
ATLLSAMENPQRYVSMDKISAKTLGETGGLGTVATRADIIEKLYKTFYIEKKGNEIVPTS
KGKQLVNLVPSDLKSPLLTAKWEGQLDAISKGKLNGVSFVNEIKGYASKLVDDVKGSKDT
FKYDNLTGTKCPECGKYMLQVNGKKGRMLVCQDRECGHRENLAMFTNVRCPECHKKLELR
GEGEGRIYVCPNCSFREKYSSFQKRFKGNNNKVNKREVSNYMKKMKKEAEAPINNAFADL
MSMFKDKN
>P96583 ## B ## Bf ## Bacillus.subtilis ## Probable DNA topoisomerase III ## Bacillus subtilis ## Probable DNA topoisomerase III (EC 5.99.1.2) (Relaxing enzyme) (Untwisting enzyme) (Swivelase) (Type I DNA topoisomerase) (NICKING-CLOSING enzyme) (Omega-protein). ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGHLVTLADPEGYGKEFQS
WRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVIATDAGREGELVARWIIEK
ANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSAVARAEADWIVGINATRALTT
KFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIRAAVDGMTLTWQDKKSKQTRTFN
QDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDLTELQRDAHKRFGFSAKETLSVLQK
LYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGMEVKPYAQYVSQIKKRGIKSHKGYVNDA
KVSDHHAIIPTEEPLVLSSLSDKERKLYDLIAKRFLAVLMPAFEYEETKVIAEIGGETFT
AKGKTVQSQGWKAVYDMAEEDDEQEDDRDQTLPALQKGDTLAVRTLTETSGQTKPPARFN
EGTLLSAMENPSAFMQGEEKGLVKTLGETGGLGTVATRADIIEKLFNSFLIEKKGQDIFI
TSKGKQLLQLVPEDLKSPALTAEWEQKLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSS
QTFRHDNITGTACPECGKMMLKVNGKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRME
LRGQGEGQTFACVCGHREKLSVFEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQL
KKLGLDK
>Q8YTT2 ## B ## Bo ## Anabaena ## DNA topoisomerase I. ## Anabaena sp. (strain PCC 7120) ## DNA topoisomerase I. ## Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
MPKRLLVVESPGKVKKLSQILGSEWIVRASCGHIRELSDEGEDALGFSMDGSSVQCHYVP
RDQRSKETIQQLKSAAKQVSEVVLGTDPDREGETIAWHLKEVLGLREPKRVVYTEITASA
VQSAIAHPRKLDLNLVGAGLCRDCLDKLVGYKGSPLVWALNNGAKSVGRVQSSTLHLICQ
REREIQSFVPQDYWSVWVDYVEGFRAFYKGAVNTRSNSPEAEVEIHDDAAGNSTTAPEST
RVLAEAEANRLVEEARRHPHQIVQYEGKVANRQPPPPFITSTLQQAAGSKLKFAPEKTMQ
LAQKLYEAGLITYMRTDSVMLSPEFCESARQWLEQNDPQNVPTQVARHRSSKTAQQGHEA
IRPTDVFRPSAQLRIELSTDEFNLYVMIWKRAIASQCRPAQLRKTVVITQSGQILWQARG
QVVEFLGYTRYWPNLSKDTLLPTLQQGQMVTLENAGHEKKQTQPPPRYSEPKLVQLMERK
GIGRPSTYSPTIATLKKRGYVELTKDNLHPTNLGLEVDTFLQKALPDLLEAEFTAKMENA
LDAIAEGKQPWQIYLTTWNQNYFAPALAKAKTVTVDSGKTTKTFPARQYDTSRTRCPDCN
NFLSKIPSSKLKKKYFLKCTSGCENTVLFWSEFSKTWQAPRTKDDKMAENGEKNHLSPST
KLPTQLTAYPCPVCKKPLEEYTYTKDGQKKTMLRCSASSSRTDKKHKDVAYFHTAKGWWS
PKFGEIT
>O87222 ## B ## Bf ## Lactococcus.lactis ## TrsI protein (EC 5.99.1.2) (tr ## Lactococcus lactis ## TrsI protein (EC 5.99.1.2) (traI) (DNA topoisomerase). ## Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
MKTIVLAEKPSQASDYANAFQKHTKKQGYFEVSDPVLANETFITYGFGHLVELASPEQYD
TKYKKWDLKNLPIFPEKYKFIVPKDKKGQFSIVSDLIKDADQIIIATDSDREGENIAWSI
LNKAKIDLKSKDIKRLWINSLEKESILNGFKNLKDGWEFYNFFKEAQTRQISDWLIGMNA
SPLFTIELQRKGINGVYSIGRVQTPTLYLVYKRYLEIKNFKPTPYFEINAEVQAGADKFN
GKLDPYIRFSDKNKLNDFAKEKNIKSGVQEGIISDVKKNLKKSQSPRLFSLSDLQTEVNK
RYHASASDTLKAVQKLYEQKILTYPRTDCNFITDNEFNYLKENLSKYISFLNKDINLNNT
NPNKRYVDSSKVQEHHAIILTKTVPSKDNFNKLSDLEKKIYQLVLKTTLAMFADPFEYEE
TVILTKVNLAIFKTIGKTPKNIGWKELFSEESKESKDDENLLPAVTIGDIVKVDLSVDQK
ETKPPIPYTEGTLIKAMKTAGKDLDDEEDQEILKDIEGIGTEATRANILETLKNKQYLLT
EKNKLTVSQQGITLCKAVELEPLLASAEMTAKWEKALKQIGQKQRTQDNFLEQIKKFITK
IINDLPNKMNDSSILNSQIKEQITTQKEIETESEISNCPICKTGKILDKGKFYGCSNYNA
DEPCKFSLPKKWSEKTLSKTIVKELIEKGETKIIKGFKSKKTGKKFDAKLKLSDGKLSFN
FDKGE
>AAS11726 ## B ## Bo ## Treponema.denticola ## DNA topoisomerase I (EC 5.99.1 ## Treponema denticola ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
MENTMNETKKTKRTAKKTKQHCLVIVESPAKAKTIEKYLGGDYIVRASMGHLIDLPKSRL
AIDIEHNFTPEYITVRGRAKILKELKKEAKKSSSVFLASDNDREGEAIAFHLHEALLPEC
SSPIKRIVFNEITPNAIQEAVKNPMDIDMGKVNAQKSRRVLDRLVGYNLSPLLWQKVKNG
LSAGRVQSVALRLICEREEEVENFIPDEYWTLDGDFKYNKTSFEAQLVKYKDNKPELKNQ
KEVDAIIKELKSLPAVVDDIKITEKSIKPRPPFTTSTLQQVAANRIGFTSKKTMQVAQQL
YEGVAVGSTRVGLITYMRTDSIRISDTAIEAVRKWINENHPKELPDGPNVYAAGKKAQDA
HEAIRPTYIEYTPSYLKEFLTRDQLRLYSLIWERFVSSQMKNAKTKTSSYEIKVGDAVFR
AASTKITEKGFYTVTKTLISKDEKGTSLPSMKVGDEISIESLRPEQHFTQGPARYTDASI
VKMLEEKGIGRPSTYAPIISVLLERYYVTRSNKQLVPTQLGRIINNLLVKNFSEIIDVNF
TAGMENRLDEVAENKIEWPKLMESFYGSFKEKVDTALENVESIKGSLDEVTDIVCEKCGN
KMVKKLGRFGVFLACSAFPECKNTKSIPLAKCPREGCGGDIIARKSKKRGKEFYGCTHFP
ECDFISHFKPINASCPKCGWFMVEKYDKKNGNYKACINPNCDYLHSVVEGVEDVEVDRSN
E
>Q9K7H4 ## B ## Bf ## Bacillus.halodurans ## DNA topoisomerase III. ## Bacillus halodurans ## DNA topoisomerase III. ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
MGAVVVIAEKPDQGMKLAAPFPHRNKRGYVEVAPCDQFPAGAFFTWAVGHLCELCPPEQY
DPSWKKWTLEALPLIPQSFVHRVSRGKKDQFQVIRSLVHRKEVTEIVMAGDAGREGELIV
RLILKQCRVKKKTSRLWLSSLTKQAVVSGFHQLKSAESTEPLYHEALSRSCADWLIGMNV
TRAYTLLLKKKGVDSLFSTGRVQTPTLALIVKREKEIEAFESKPFWEVKATFRVQGHEYE
GIWHKDRETRLFDQPMAEAIAAFCRGKQGKVTKVKKETKTLKPPYLFNLSSLQATANKRF
TFSPKKTLDVAQKLYVKGHISYPRTDSSFLTAEEGKAAKRIVQLLKQEDAYASLFPLDRD
NLLQDRRYVNQSKVTDHYAIIPTDDVPKVQTLAKDEQLLYDLIVRQFLAAHMREAKIAYT
EVETLVDERATFLTKGKQLLDQGWKQIIGLSKDDKDEDIPPLEEGWTGDVKHADVREGKT
KPPSRYTEGQLITLMKTVGKHVEDDELEKVLMRTEGLGTEATRAGIITLLKDRQYIEIKK
NVVYATEKGKLLIEALGPSLLASPEMTAKWEQRLFEIGRGQADAHAFMEQVKKLSDHLVK
EAHQRANTWDFSSFDQEALEEKTKKRKKRRPTYVGSCLACDGKLLDRGEFYGCTNYEAKS
CRFTISKTILGKRLSQANVKKLLQGETTNVIKGLKKGSDTFDAKLYWDKEKKKLGFQPVE
S
>Q8A5Z7 ## B ## Bo ## Bacteroides.thetaiotaomicron ## DNA topoisomerase III. ## Bacteroides thetaiotaomicron ## DNA topoisomerase III. ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Bacteroidaceae; Bacteroides.
MIVCIAEKPSVARDIAEVLGAHTRKEGYIEGNGYQVTWTFGHLCTLKEPHEYTPNWKSWN
LGSLPMIPPRFGIKLIENPTYEKQFHIIEGLMQNADEIINCGDAGQEGELIQRWVMQKAG
ARCPVKRLWISSLTEEAIREGFAKLKDQSDFQSLYEAGLSRAMGDWLLGMNATRLYTIKY
GQNKQVLSIGRVQTPTLALIVNRQLEIANFQPKQYWELKTNYRDTTFSALIRKSDEEIAA
EEEKSGGKKKIDNPGIDPIANREEGEALVERIKDLPFIVTNVGKKDGKEYAPRLFDLTSL
QVECNKKFAYSADETLKLIQSLYEKKVATYPRVDTTFLSDDIYPKCPGILKGLRDYEVLT
APLSGASLPKSKKVFDNSKVTDHHAIIPTGVYAQNLTDMERRVYDLIARRFIAVFYPDCK
ISTTTVMGEVDKIEFKVIGKQILEPGWRVVFAKDVKDTSEEKEEEDENVLPAFVKGESGP
HVPDLNEKWTQPPRPYTEATLLRAMETAGKLVDNDELRDALKENGIGRPSTRAAIIETLF
KRNYIRKERKNLIATPTGVELVQIIHEELLKSAELTGIWEKKLREIEKKTYDARQFLEEL
KQMVSEIVMSVLSDNTNRRITIQEAVAQTEEKAKKEPKKRERKASAPKEKKAKAEPKVPA
SSPSPALTPSAPASAPATGNADTFVGQPCPVCGKGTIIKGKTAYGCSEWRNGCTYRKNFE

>Q8EN97 ## B ## Bf ## Oceanobacillus.iheyensis ## DNA topoisomerase III (EC 5.99 ## Oceanobacillus iheyensis ## DNA topoisomerase III (EC 5.99.1.2). ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Oceanobacillus.
MSKTVVLAEKPSVGRDIAKVLGCHKKGNGFLEGSKYIVTWALGHLVTLADPDMYDSKYKT
WRMEDLPMLPDHLKLVVMKKTGKQFQSVKTQLNRQDVVEIVIATDAGREGELVARWIIEK
ARVKKPIKRLWISSVTEKAIKDGFKQLKPGKNYWNLYQSAVARSEADWYVGLNATRALTT
KHNAQLSSGRVQTPTLEMVSLREQEIKNFQPKKFYQLEAKTTKGHRFLWKNDENQNRIFS
KNEAIKLEEKLSNKQATVVHVDKKLKKKHAQGLYDLTDLQRDANRIFQFSGKQTLSVMQK
LYEQHKLVTYPRTDSRHLSTDIVSTLKDRVKACGVDEYAKIANTILNKELRLNKSVVDNA
KVTDHHAIIPTEVPVVWTALDDKEKKIYHLIVQRFLAALSDPMEYEQTTITIDIAGEQFI
ANGKVTKRLGWKEIYKHNDEEDEIQPLNVTKGSKLTLKVELKEGETKPPERFTEGTILQA
MENPTRYMGTNKKELVDTIKETGGIGTVATRADIIEKLFMNSYIELKGRNIYLTQTGRQL
LDLAPEELRSPLLTAEWEQKLSLIAEGKLKKDQFIKEIKSYTKEAVTEIKQSSETFKHDN
MTGTKCPKCGKLMLEIKNKHGKKLVCQDRSCGGKKNIAKFTNARCPNCHKRLELRGEGEG
QIFTCKCGHREKLSTFQARKEKEKKQRVSKKDVKKYLNKQDEGFKNNALADALAKLKNDE

>AAF19045 ## B ## Bf ## Mycoplasma.gallisepticum ## DNA topoisomerase I. ## Mycoplasma gallisepticum ## DNA topoisomerase I. ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MTNHSSKILVIESPNKVKTIKKYLTDDYEIVATVGHIRDLPKYTLGFNTEDFVPKWEIIQ
EKKPAKGTRATKKAKTVKKAVKNKKEIIDELVDKAKKADEIYLATDPDREGEAISWHVYD
VLKEKGVNVNKCKRIIFNEISEKAVKNAIANPREIQKDWVSSQITRRRLDRLIGFKLSSL
MKSKINADCAGRVQSIALKFITEREELINKFVPRFWWTLDVILKDGTELMLRKIDEKLKD
KLGYKELEEVSGIDFNTKEDAELVKQHLSDKYRVYAIDTPKLKSSYPKEVYKTSTLQQDA
INKLKWRSMKITSVAQELYEGVTIDDEQIALISYPRTDSTRLSPEYGKTVLDFVAKTYGK
DYVATQSQLNGETKANKKQKAKVQDAHEAIHPIDISITPDSVKNKISSDQYSLYKLIWTR
TVAHYMAAAVYELVNIRFINNNNKFYAVNNTLKFDGYKKIYTHYDDKDHLRKLDLNHFAI
DKEFEAKDVLLNEHQTKPPARFTQATLIEALETEGIGRPSTYLTILDIVLKRNYAELVNG
RYYKTTDLGQKLAFELDKNFPTIINKEFTKNMETTLDEIAQGTVNDVSYLQAFWNDFSEV
LNEAKTNIVKKVEYIEGKNCPNCSSQLVRREGRYGPFVGCSNFPKCKFIEKSEQKPKEIV
YEEGVECELCHAKLIRRVAKKKGRNKDNTFLGCSNFPKCKYTKSLEPEKDETIRDSTII
>Q8CS09 ## B ## Bf ## Staphylococcus.epidermidis ## DNA topoisomerase III topB. ## Staphylococcus epidermidis ## DNA topoisomerase III topB. ## Bacteria; Firmicutes; Bacillales; Staphylococcus.
MTILIIAEKPNQVKKYVEALGNSFNNKDGYIELESELFDKKVIVTWCVGHLIQLAHMEDY
DSNLKQWSKDTLPFIPEDFIFKVSDYGSKQFKIIKELCENLNSDSEIIIATDPDREGEAI
ARYVLNKIPCTKNLKLKRLWANTQEPEGLKLAFKNLKDADDTYRFYLEAEARSIADWLVG
MNFTRYVTLEMKQLGIDEGVFSVGRVQTPTLYMVYKRNNEIKNFESKTYYEMVAKDKENE
NAVFKSEHKFDSIDEFEQFLNENNLNCECEGEIKEISISEKRKVAPNLFKLGGIQKVANQ
KWGYTLDKTLSIVQSLYDKGYLSYPRTDCSLITHSEFEYLKDNFSSYCKLLNIEIEQKNI
EPRTQYVNDSKVLEHYAIIPTKQIPENDVYNNFSDDEKKIYDEVVKRTMLMFMEDYIYSE
TKIVLCIENVEFKLTGNVAKEQGWKLLDSENKNSKEKLLPNYKENEKLSLNLVPKELNTK
PPKYLTEATLGGEGGLMENCSKFIENEELKGNLKEVHGIGTPATRSSIVKSLIDRGYLET
KKKHLMITPKGTLLCSALENTNLVSVEMTANWESTLKDISEKGHRIRQNEFIDSIKQYIK
QMINSDNKLLKLESNDKNIEKAIEQSTICNCPKCSNGRIKKLLSKNKKLFYACSNKDCDF
IIFGMISNKNITPQIVKEIIEKGKTKTIKGFTSKAGKKFNAKLKLTEKGVEFDFNKKK
>Q9F544 ## B ## Bp ## Escherichia.coli ## YdgA protein (EC 5.99.1.2) (DN ## Escherichia coli ## YdgA protein (EC 5.99.1.2) (DNA topoisomerase). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
MKLFIAEKPAVANDIVKALGGNFTRHDGWFESDNTIVTNCFGHIIESQPPENYNPEYKEW
KIETLPLRLYPVKYQPVESAEKQVKTIIELIRRADVTEIIHAGDPDDEGQLLVDEVLEYA
GNTKPVKRVLINDNTLPAVKKALANPKNNRDFRGLYLKALARSVADAIYGLSMTRAYTIP
AKTKGYKGVLSVGRVQTPVLGLIVNRTRANKNHKSSFYYTMTGHFQRGADVIRANWKPGE
FAPLTDRKLLDKTWANGTATSLAGKPATVEAAATDDKKTAAPLPFNLVRLQQYMNKKFKM
TAQKTLDITQQLREKYKAITYNRSDCSYLSDEQFSEAPQIIDALKSVFDQPMDIDTTRKS
KAFNSAKVTAHTAIIPTVSVPDVNALSTDERNVYLAIAQHYLVQFMPEKAYQEVSVAIQC
GDESFYARARKTTDSGFEAFLGVENAGDDEAEVENDDSDFDLLCKIRTGETVTTKEVVVN
EKKTTPPPLFTEATLLAALVRVADFVTDPVIKKLLKEKDRDKKDEHGGIGTPATRASILE
TLKKRNYITLEKGKLIPTDTGYALIDALPDIAVNPDMTALWAEKQTLIENGEMTIEQFVD
ELYNDLIPMISNANSAEIKVSPSAPSGQSQRLSSPCPSCGKQIVIRPKSYSCTGCEFKIW
NEFSGKKITQAQAEKLIKSGKTDLIKGFKKKSGGTYDAVLVLEDKKTGKLGFPARAKK
>TOP1_METTH ## A ## Ae ## Methanobacterium.thermoautotrophicum ## DNA topoisomerase I (EC 5.99.1 ## Methanobacterium thermoautotrophicum ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
MRSLSGKMHEVIICEKPKSSEKIAGALFPDAMKKKHGKVSYWEHVEGDKRVTIVSAVGHL
YSLRPRQSNEEHFFDLEWAPIHEIDKKKGYVKDYLNVIRKFAAGADRYIHACDYDIEGTL
IGFNALKYGCGEEALRKTSRMKFSTLTREEIQRAYKNPIEVDYGQVDSGAARHILDFIFG
VNISRSLMKSVKAATNRFIKLSAGRVQTPTLAILVEREKEIRDFKPVPYWIIRAELGEGI
IAESKRGKIFKRELVDSILEKCQGSDAEVKDVRVRDTIRKPPVPFDLGTLQSEAYRVFGF
SPKKTQTIAQNLYTEGYTSYPRTSSQKLPESIGYEKILKNLAKNPRFGVHIERLRGPLKP
HEGKKEDDAHPAIHPTGLLPSELSKDEKKVYDLIVHRFISVFGEDAILQTMKVELEIGEE
EFSFSRKRVSKAGWMESYPYTKMEDEEFPEISGGDSLAVRSVSADERETKPPARYNEASL
IRELERRGLGTKSTRADIIAKLYDRKYIEGKKIRVSPLGENIIDTLTRYCEKIISEELTR
QFERELEDIMRGKISKDRVIDEAITEVRSILSDIEENLRDIGKELYRAYQDSRVVGECPA
CGGKLVIKYSPRNRSTFVGCSSYPDCRTVYSLPRGASVLKSLCEKCGLPMISYGRPRQRA
CLDPKCGKKKSEVEEVVGKCPECGSDLIKRSGRYGEFVGCKGFPKCRFTCSVDEVPEG
>AAT05509 ## B ## Bf ## Listeria.monocytogenes ## DNA topoisomerase III (EC 5.99 ## Listeria monocytogenes str. 4b F2365 ## DNA topoisomerase III (EC 5.99.1.2). ## Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria; Listeria monocytogenes.
MTKTLVLAEKPSVGKDIGRVLGAKQGKNGYLEGGKYVVTWALGHLVTLADPERYDSKYKN
WNMEDLPMLPEKMKLEPIKQTRKQYETVKKLMNRTDITTIVIATDAGREGELVARWIIDY
AKIKKPLKRLWISSVTDKAIREGFEHLKPGKAYENLYHSAVARSEADWVVGINATRALTT
KYNAQLSCGRVQTPTLAMIQHREEEIRNFKPREYYGITALTEQESFTWNNGQTFDKALAE
KLVKSLQGENAVITDVSMKEKKNFSPGLYDLTELQRDANNRYDFSAKETLNIMQTLYERH
KVLTYPRTDSRFISTDIVPTLKERLAACGVGENAKAARQISGKPIKANKSFVDNSKVSDH
HAIIPTEQPVSLGDLSDKERKIYDLVVKRFLAVLSDPYIYEETSVKAKIGQEEFTLKGKV
VKSLGWKSIYGESREPDQLTKMKKGDTIPVKRINLETGKTKPPARFNEATLLSAMENPSK
YMETTNKALAKTLGETGGLGTVATRADIIEKLFNSFSLEKQGKDIHITSKGRQLLELVPE
DLKSPELTARWEQKLSKIAKGELDYRKFTEEMRNYAKKAVTEIKQNDKKFRHDNITSQKC
PDCGKPMLKVKGKRGTMLVCQDRECGHRESVSRTTNARCPNCHKRMEMRGEGDKQIFVCV
CGHREKLPAFQQRRDKQKNKNVSKTDVAKFMKKQNKQEDGPFNNPMAEALAKLKLDK
>CAF28714 ## A ## Ac ## uncultured.crenarchaeote ## Putative DNA topoisomerase I. ## uncultured crenarchaeote ## Putative DNA topoisomerase I. ## Archaea; Crenarchaeota; environmental samples.
MSEDNVMAVKGYQLVICEKPLAAKRISQVLGSKNIIEKKYSLGIVVFEITSDKNQRFVVC
SALGHMYSLIPLEKNRKKYPIYETVWSPKHSTVANQRKRILETLKVIARISEGASGYIHA
CDYDLEGELIGYNILEYACKHKYEQSRRAKFSSLTDSEINQSFNNLQQTDIRIAEAGKAR
HLVDFVFGINLSRALVNCLSVANQDNRYYNLSIGRVQGPTLGFIVDREIKIRKHVPDPVW
YITGNFQKDNSSFQANLSTAIHKFSEMQKILATCKNGKATIKTVICQTKKVNPPTPFNLS
DLQKEAFRIFKLSPAVTHSIAESLYLAALISYPRTSSKKLPSSIGYEKILNLLSKNYATA
DKNKIQELLMQKYLVPFQGIEEDPAHPAIYPTGLKHKKLSVQQSKILDLIIKRFLATFGD
GALTNFSEVIITVSGYDFIAKGNTILNYGWIPLYEPYFSIKETRLPHLVKGDSAQTNEVT
ALEDFTKPVARYNQASILEKMESEGIGTKSTRAETVNLLIKRNYILQHKIGLEPTVLGFT
ILDTMKKFIPDIVSTKLTAFLESSIKRVEQGELDMINLRKHLEKSLLKPLNRIKINEMAI
GNEIKNGLTTSRVEMSYGKCPKCHIGEMVLIKSNKTKKRFLACSKFRVTGCKTITIVPQF
GLIKNDNSVCTCGWPILRIIFKRFSPRKICVNRSCRENLSNRTDDHRNLDPNTSI
>AAS40908 ## B ## Bf ## Bacillus.cereus ## DNA topoisomerase III (EC 5.99 ## Bacillus cereus (strain ATCC 10987) ## DNA topoisomerase III (EC 5.99.1.2). ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
MKLIIAEKPDQGLALVSQFKYRRKDGYLEVEANELFPNGAYCTWAIGHLTQLCNPEHYHA
EWKKWSLDTLPMIPERFQFEVTKSKYKQFNVVKQLLHNPQVTEIIHAGDAGREGELIVRN
IINLCNVQKPMKRLWISSLTKQAIYQGFKNLLDESDTINTYYEAYTRSCADWVVGMNASR
VFSILLKKKGMNDVFSAGRVQTPTLALIVKREKEIENFKSEPFWEVFATFNIEGKKYEGK
WEKDSESRLKDPDMANKIAAFCQGKPAVVKEMKTERKEFQPPLLFNLSSLQATANKAFKF
SPKKTLDITQALYQKGIVSYPRSDSNYVTQGEAATFPDILQKLSQFDEYKGLLPAPVESI
MNNKRYVNEKKVTDHYAIIPTEQVTNPSKLSGDEKKIYDMIVRRLIAAHYEVAIFDYTTI
VTLVDERAEFISKGKQQIQEGWRKVIFQDDKDDETILPIVAEGEEGKVVKVKVKEGKTQP
PKRYTEGQLITLMKTAGKYLENEELEKVLKKTEGLGTEATRAGIITMLKDRKYIDVKKNQ
VYATDKGKVLITAIGDKILASPEMTAKWEQRLAEIGEGTASPATFMEQTKKLSAKIIEDA
VEMSEKWDFTGLHVESIERKGSKFTTGKKVGSCKKCDGDVIDKSTFYGCSNYNTTQCDFT
ISKKILSKTISQKNMTKLLKGEKTDLIKGFKKGEKTFDAKLEWKDNKINFVFEN
>Q97DB3 ## B ## Bf ## Clostridium.acetobutylicum ## Topoisomerase B. ## Clostridium acetobutylicum ## Topoisomerase B. ## Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
MRKILVISEKPSVGRDIANVLGCKTRGEGCLIGAKYIVTWAVGHLVTLWEPEEYNAIYKK
WRFDTLPIIPEVMKIKPIDGTKKQFNIIKKLMNDNSVESLICATDAGREGELIFRYTYEA
AECKKPFSRLWISSMTDEAIKEGFSTIKPGTEYDNLYHSAKCRSEADWLVGMNASRAYTL
KYNVLLSVGRVQTPTLAIIVKRQKEIDNFEPKDYWEVVSKYEGFNGTWFDKETKESKIMD
KKKADDLGAKILGQTGKVISIENKKKKQVPPLLYDLTELQRDCNKKFGFSAQKTLDIVQS
LYEKRKMVTYPRTDSRYLSHDMVNKIKKTIGRLNINPYDKYVGEILKLSKLPMGKRIIDD
SKVTDHHAIIPTDVKPNLSTLTKDELKVYDAIVRRFLCVFYPNYEYTITKIVTEVVEENF
LTQGKTILKLGWMEFYKHDKKEKDDENSEPDELPKLKKNESVQVKDSEIKAKKTKAPSSY
TEASLLSAMENAGRFVEDEQLKEQLKDGGLGTPATRASIIERLIQVGYIQRKGKSLHPTD
KGMKLIEIVPYELRSPETTGKWEKGLSSISKGKMASERFMQSIKRYVQYIIQESVKVNRS
VVFQNNDSKFPQKNKQLPEAIGECPFCKRGKVYENSKAFYCSEWKGGCKFTTWKDSLKNY
GIQVDKDLEKKLLKERVLYNVFGIEPKSGEKTVYTLKMNNYGAVIAKTQ
>Q8EVZ3 ## B ## Bf ## Mycoplasma.penetrans ## DNA topoisomerase I. ## Mycoplasma penetrans ## DNA topoisomerase I. ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MDKLLIIESPNKIKTLTKYLGKDYEIIATIGHIRDLNQFGMGFDADFEPKWVIPSVKKNS
KNKNEVSKKEIVEKLKKSASKAKEIYIATDPDREGEAIAWHVYEVLDAASQKKCKRITFN
EITKNAILESLNHKRDIDINWVQSQFARRIIDRLIGFKLSKLLQTKLKADSAGRVQSVAL
KFIEDREKEIRNFVAENWWTLDVMLEDNNSLILKSIDPNLKNIKLSEKKFSTSGLDIADE
ESANNLLNALDKKFKVKSIEEPSFYSSYPKSPYKTSTLQQDAINKLGWNSKKITLIAQHL
YEGVEVDGNQIALISYPRTDSLRLSDTFVQSAFKFIEETYGKDYVGKYQVKSSANDANTQ
DAHEAIRPIDPYLTPQELKNKISKDEFALYQLIYNRTVASLMAAAKFKKVTIKFDNNNCE
FYTFSRECLFLGFKKLYVEDNEDEENKLIDLNNYPVGKEFKSKVMEVKKHETQPPQRYTQ
ATLIGDLESAGVGRPSTYSSMANIALERGYAVTDKKAYVMTDIGKIVVDQLEKFFPDIIN
KDFTKKMEEHLDQIASGNEEWKSWLKKFAPGFDEEVKKAYDTMEKISDEKVGRECPKCGK
DLLYKRARRGGSKFIGCSGYPECTHLEPLEKPEELEISCPECGSKLLKRKSKRQQVFVGC
SSWPKCNYIISDKLFDKHMKETPDKPLPSKKELEEIRAARLPKWKKN
>Q832C6 ## B ## Bf ## Enterococcus.faecalis ## DNA topoisomerase III. ## Enterococcus faecalis (Streptococcus faecalis) ## DNA topoisomerase III. ## Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
MQLVIAEKPSVGMALSKVLGAKSRGDGYMEGGGWLVSWCIGHLVELAPADAYDPRYSKWN
YADLPILPKPWQFQVLPDTKKQFEVLKTLIHRADVTALICATDAGREGELIFRLTYHLCG
CTKPVKRLWISSMEEAAIQKGFDNLLDGKNYDNLYAAALCRAKADWLIGINGTRLFTTLY
QGKSLNVGRVQTPTLALLAEREAAISGFQKEKFYTVELELEGFRAASERFASKTDAGRLR
TGCVGKPATVQTVSQKEKTERPPKLYDLTTLQREANRLFDYTAQQTLDYLQALYEKRLAT
YPRTDSRYLTEDMAAGLPALCQSVAAALPFAADLSLPVNAAQVIDNSKVTDHHAILPTTE
AAKTDLSALPSGEKNILFLVAARLLCAVGEPHTYAETAVTLECGGAVFSAKGKTETAAGW
TAMEQAFHATLKKKPKQPEPSPPLPALTKGQKLTAGGASIKEGATSPPAHFTEDTLLSAM
EHASAKEFAKLEDVEHKGLGTPATRAGVIEKLVRSGFVERKKKQLFPTEKGTELIKVMPD
TLKSVKLTAEWEERLGAVERGELSPEDFMAGITAMLTELVKSYQGVTVASAALSASGRTV
IGICPRCGKNVVEGKKSFFCEGWNAAPACDFALWKNDRFFTSKHKELTRKAAAALLKKGR
VAMTGLFSEKKGVLYDAIVVMEDTGEKFVRFKLEFDNNTPKKKGN
>Q8ECS1 ## B ## Bp ## Shewanella.oneidensis ## DNA topoisomerase III. ## Shewanella oneidensis ## DNA topoisomerase III. ## Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales; Alteromonadaceae; Shewanella.
MILYIAEKPSLGRAIADVLPKPHKKGEGFIEDANGNCVSWCVGHLLEQAEPDAYNPDFKS
WKFEHLPIVPEKWQLKPKAATRSQLTVLKKLIKQADTLVNAGDPDREGQLLVDEVIAYLG
VTGDKLQQTQRLLISDLNPQAVKRALSQLRSNREFIPLSTSALARSRADWLYGMNMTRAY
TIQGKKVGYQGVLSVGRVQTPLLGLIVRRDEEIAHFQSKPFYEVLAHLVTDKQQFFSAKW
QPSEACQPYMDDEGRVLSKGLAQNVVRRITDKPAKVTQLSTKDKQQSAPLPYSLSALQID
AAKRFGMSAKEVLDTCQSLYERHKLITYPRSDSRYLPTEQHGLASSVLNAITSGAPELVA
HSEAPNPRLKSKAWDDKKVDAHHAIIPTEKQPNLGSLSQRERQLYLHIARQYLAQFYPAY
CYSETAVEVTIEGGLFKTKARQDKSLGWKQLFAREEGERKDTSNTETFAQDDKDKDEGEY
AGQLPPLILGQVLHCNQGELVEKQTQPPKAFTDATLLGAMTGINRYVTDPEIRKILKETD
GLGTEATRAGIIELLFKRGFIQRQGKSIVATEVGKGLINSLPLSATTPDMTALWEASLNG
ICHKDISYQGFMQPLLGTLHSLIQNAGAQLPSALNGLKGQGFKRAATKKSGYRKAGVRGA
AGGKKAGTGAKNARNSAAASSTSTTAKPTVPRRRTSKATAQA
>TOP1_CAMJE ## B ## Bp ## Campylobacter.jejuni ## DNA topoisomerase I (EC 5.99.1 ## Campylobacter jejuni ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae; Campylobacter.
MKKNLIIVESPAKAKTIGNFLGKDYEVIASKGHIRDLPKSSFGIKIEDDEFIPEYRITSD
HSALVKELKSKAKDAKEVYLATDEDREGEAIAYHIAKAIGKDENTLPRIVFHEITKSAIE
NALKNPRKLNMHSVNAQQTRRLLDRIVGYKLSPLLGQKIQRGLSAGRVQSAALKIIVDRE
KEIRAFVPLEYFSIDMIFQKDLDAELVEFDKAKIEKLTITNKDRAKLILEACKNEVYSIS
DIESKERKIAPPPPFMTSTLQQSASNRLGFNPKKTMMIAQKLYEGVNTHEGVMGVITYMR
TDSLNLAKEAVENARKFIQANFGKDYLPSKANVYTTKTKGAQEAHEAIRPTNLSFTPEIA
AKFLDKDELKLYTLIYNRFLACQMSPAISQTQNVFVKNDRVVFKISGRKILFDGYYKVYG
DMDKDKILPNFKIGQNLKVQNLEMNSHFTEPPSRYSEAGLVKKLESLGIGRPSTYAPTIS
ILTSRDYVTIDKKQLIPSDVAFNVTEVLEKNFSDIVDSKFTSNLENTLDEIAEDKADWQE
TLKEFYYPFMRKIEEGKTKIASQKTVTKLGESCPDCGGELAIRKGRFGEFVACLNFPKCK
YSRNLKSESKNESENTAAKAKANGTGITCPSCQKGEIVERFSKRGKFYGCSAYPKCNFIS
KYKPSEEKCEECGETLVIKELKKGTFLECLKCKIKKEMKD
>Q8A5B5 ## B ## Bo ## Bacteroides.thetaiotaomicron ## DNA topoisomerase III. ## Bacteroides thetaiotaomicron ## DNA topoisomerase III. ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Bacteroidaceae; Bacteroides.
MKVIIAEKPSVAQAIASVVGAHQRKEGYLMGGGYAVAWAFGHLVGLAMPESYGLSGFRRE
HLPILPQEFRLVPRQVREGKAYKDDPGVVRQLGVIRDLFDRCESIIVATDAGREGELIFR
YVYNYLGCTKPFARLWISSLTDKAIREGLQNLREGSLYDNLYLSAKARSEADWLVGINSS
QALSLAAGQGVFSLGRVQTPTLAMICSRYRENRQFEPRTYFRIKVSAAKDGIDFSALSQN
RFDDLDSATARLREIKDGCMLAVTSVERREAVQEPPLLYDLTALQKEANSKLDFSADKTL
TLAQSLYEKKVLSYPRTGSRYISEDVFDEIPSRIMLLRQYPRFTATASVLPDAPLNRRPV
DDAKVTDHHALLITENLPEGLSQDEQAIYEMVAARLLEAFLPCCVKEMTEVALSAGGEIF
TLKGAVIKSAGWRAVRGEPEEEAEETTLPGLQTGETLPLLASETVEKQTKPQPLHTESSL
LSAMEHCGKEISDEQLRAGIREIGIGTPATRAAVIETLFARDYIRRDKKNLVPTEKGLAV
YDTVKDKKIADVEMTAAWENTLAKIETGEADALSFRRNIEVYTAQIVTELLAATLNVAPS
GEQCTCPKCRKSRILFFDKVAKCADVDCSFTLFRNKGGKILTDGQIIELATKGRTPLVKG
FKSREGKSFDAALVLNPDFTIGYSFPDRKPQEKKSGRKK
>TOP1_FERIS ## B ## Bo ## Fervidobacterium.islandicum ## DNA topoisomerase I (EC 5.99.1 ## Fervidobacterium islandicum ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Fervidobacterium.
MAKSKVVEKDKKNELDNQSADIELKGQSKNEESKGGKKKVIIVESPAKAKTIERILGNDY
QVISSKGHIRDLPQKQFGVDLNSLKLDFEIIPGKESVVEQIKKMTSGKEVLLPSDQDREG
EAIAWHLSTILGVKGKNIITFTEITERAIKEAVKNPREIDMNKVNAQLARRVLDRIVGYM
ISPLLWRIIKDARSAGRVQSAALKIICERERERYRFVPQKYFKVWIDIAGLKAYLTKVDG
KKIKPTDITEEISKDVLQKVKSVRLVDIDVKEVRKNPPAPFITSTLQQDAASKLGFPVSK
TMKIAQELYEGVDTKEGHTAFITYMRTDSTRVSDVAKEAAEKFILKNFGREYLNESSEVA
SKKGSKTKGKVQDAHECIRPVDVNITPEKAKELLDKDHHKLYELIWKRFIASQMSSAIYK
QYSYDFESGKYVFEASIRERIFDGFEKVYTIDNEPSEKHKELKVDQEYLVEPKSAEAQTT
PPDRYTEASLVKTLEMEGIGRPSTYATIIQTLLDRGYVVKKRKTLIPTILGFVVNHYLEQ
RFPDIVDKGFTAEMEKELDEVENGKKDWKEVVKSFLKEFNKDLERAKNEFFAIDFDTDIT
CEDCSGNYKLKVGKYGLYLHCPNCKTNKALKSDVFGVIDGNKLYVLEEQESQEENGEKNS
VQSEESSANSGNRKFYRKRRTSGSKKSSTKSASSKAKKK
>Q7MUL3 ## B ## Bo ## Porphyromonas.gingivalis ## DNA topoisomerase III. ## Porphyromonas gingivalis (Bacteroides gingivalis) ## DNA topoisomerase III. ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Porphyromonadaceae; Porphyromonas.
MKCIIAEKPSVARDIARIVGATHKEEGCFSGNGHVVTWAFGHLVTLAMPEAYGFPTYSRE
QLPIIPEPFRLVVRQIRKGTTYTDDPSALKQLNIIRKCFDRSDHIIVATDAGREGELIFR
LIYAYLDCRKPFDRLWISSLTDKAIREGLSRPADGRQYDRLYLSGKARSEADWLVGINAS
RALSIARGGAYSLGRVQTPTLSMICRRYIEHRDFRSVPFWKIHALPTGLSVKAIGETTYE
SRRAADRAMKDLDPREALIVSSVSVQTNPVPPPLLYDLTALQKEANKRYGYTAEKTLSLA
QSLYEKKCTTYPRTGSRYISEDIFEEIPSLLESLKDDPDYGDYVEKLTAGTLNRRSVDDT
KVTDHHAILLTGEKSDSLTRDEEVLYRMVTVRMLESFSEAAIEETLTAILSQREHRFGIK
AKRRVKSGWKAIRGSMEEPVEEGETVVDSFPEWQEGDRLDVFGFEMTEHQTKPKPLYTEA
MLLSAMEHAGREVADEEARKALAGCGIGTPATRAAIIETLILREYIRREKKMLIPTEKGL
SVYKLVAGRKIADAEMTGAWEVALAAIEAGAMDERTFGKSIEVYTRQICEELLTTAAGNT
DAHYKTYRCPLCGNDSVRVFPKIVKCVTDGCGFKVFRELCGTLLSKEYIHALMTDGCTPL
LCRLTGKSGKTFNARLKLDKDGGTSFVFDSKPRKPQT
>Q895L4 ## B ## Bf ## Clostridium.tetani ## DNA topoisomerase I (EC 5.99.1 ## Clostridium tetani ## DNA topoisomerase I (EC 5.99.1.2). ## Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
MIMGQKLIIVESPAKAKTIGKYLDKTYHVEASMGHIRDLPKSQLGVDIDNNYEPKYITIR
GKGELLTKIKKHAKKCDEIYLATDPDREGEAISWHLSQALKLEDNKKCRIVFNEITKSAV
KNAIKEPREIDIDLVNAQQARRVLDRLVGYKISPILWRKVRWGLSAGRVQSVVLKMICDR
EKEIEEFIPKEYWTIECKLNKDRKDFLVKLISKDNKKIEINTEEESNNIIKELKQGQFTV
DKIKKTNKNKNPLPPFITSTLQQDAYRKLNFSTKKTMSVAQQLYEGIDIKGHGTVGLITY
MRTDSVRISKEAQNKARQFLENVYGKEYIPEKPRDYKGKKNIQDAHEAIRPTNIEITPKI
ALENLNSDQYKLYSLIWNRFMASQMAACVMEVNSVDVKNSEYIFRATGSIVKFDGFMIIY
EYLNEDEKENINIPKLEKGELLKEKSIDSKQHFTQPPGRFSEASLVKVLEDNGIGRPSTY
APIISTLLERTYIERENRTLKSTELGVIVNNIMVEYFKPVVDAEFTAEMENKLDSIEEGN
ENWKNTVDEFYSPLKELIETAEKEVEKVTLEEKVTDVKCEKCGNNMVVKHGRFGDFLACP
GYPECKNTKPIVHQLDVKCPKCHGEIVLKKSKKGRKFYGCSNYPKCDFVSWFEPVERKCD
VCGNYMVKRYTKAKGDYIECSNKECKHKIMPEKKQE
>Q8G9E1 ## B ## Bo ## Bacteroides.thetaiotaomicron ## Exc protein. ## Bacteroides thetaiotaomicron ## Exc protein. ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Bacteroidaceae; Bacteroides.
MKTIIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRGFVRD
NLPIIPDTFTLVPRQVRTEKGYKPDSGVVSQIKVIKRLFDTSEHIIVATDAGREGELIFR
YLYHYTGCTTPFVRLWISSLTDKAIREGLRKLEDGSKYDNLYLAAKARSESDWLVGINGT
QALSIAAGHGTYSVGRVQTPTLAMVCERYWENRRFTSEAFWLLHIATDGCDGEVVKFSSS
EKWKEKEPAMELYNKVKAAGCATVTKAERKEKTEETPLLYDLTTLQKEANAKHGFTAEQT
LEIAQKLYEKKLITYPRTGSRYIPEDVFAEIPKLLAFIGTQPEWKDKVRAKAAPTRRSVD
DGKVTDHHALLVTGEKPLFLSKEDNTIYQMIAGRMVEAFSEKCVKDVTTVTAECAGVEFT
VKGSVVKQTGWRAVYGEEKEEITIPGWQEGDTLTPKGSSITEGKTKPKPLHTEATLLSAM
ETAGKEIEDDALRQAMKDCGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVV
KTMRIADVAMTGEWEKELARIERGELSADTFRKEIEAYTREITSELLSCDKLFGSRDSGC
ACPKCGTGRMRFYGKVVRCDNTECGLPVFRLKAGRTLSDDEIKDLLTEGHTKLLKGFKSK
QGKSFDAVVAFDGEYNTTFVFPEAKKGKKFSGRKK
>Q8R9Y1 ## B ## Bf ## Thermoanaerobacter.tengcongensis ## Topoisomerase IA. ## Thermoanaerobacter tengcongensis ## Topoisomerase IA. ## Bacteria; Firmicutes; Clostridia; Thermoanaerobacteriales; Thermoanaerobacteriaceae; Thermoanaerobacter.
MAKSLVIVESPAKAKTISKFLGKNFKVAASQGHVRDLPKSQLGVDIENNFAPKYITIRGK
GEIIEKLKKEAKDAEKIFLATDPDREGEAISWHIAQLLDLDIDKPCRIEFHEITKNAVQA
AIKNPRKIDLNLVNAQQARRILDRLVGYKISPILWKKIKRGLSAGRVQSVAARLVCDRER
EIEAFVPEEYWNITAVLFDEKTSSKFEAKFYGREEEKIELKNREEVDKIINSLSEEYVVY
KVKTGTKKRNPPPPFITSTLQQEASRKLGFTAKKTMLIAQQLYEGIEIKGEGSVGLVTYI
RTDSTRVAKEAKEEAYRYITEKFGKEYANPDAEYSSKKANVQDAHEAIRPTSVFREPEII
KDSLTPDQYKLYKLIWDRFIASQMMPAIYDTVAMDIKNNGYIFKASGSSVKFLGFMTVYV
EGSDFQEEEEEKTLPVLKEGTKVRLEELKPTQHFTQPPPRYTEASLIKELEEKGIGRPST
YAPTIATLLERGYVVKDKKVLKPTELGFIVTDALKEFFSEIVDVGFTAEMEEQLDKIEEG
KVEWYEVVGDFYRDFYKTLKVAEEQMEKVELEEEVEVTDIKCEVCGRPMVVRKGRYGKFL
ACSGFPECKNTKPLLEKVGVKCPKCGGEIVKRRSKKGRVYYSCENAPQCDFVLWDKPVNE
KCPVCGSLMVEKNTKNGIVIKCSNPECGYQKETN
>Q833A3 ## B ## Bf ## Enterococcus.faecalis ## DNA topoisomerase III. ## Enterococcus faecalis (Streptococcus faecalis) ## DNA topoisomerase III. ## Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
MVAKQLIIAEKPSVAKDLSRVLGANQKNKNYYEGPNVIVTWALGHLLGLKMPEDLNKEWQ
TWQMETLPMIPKNLGIKPLPKTGHQLKAIKQLANRKDVSEAVIATDAGREGELVARWILE
YVRFNKPVKRLWISSQTDKAIKDGFKKIRPAKDYDNLYYSALARAKADWLVGLNVTRALT
VKYQDNLSAGRVQTPTLAMVRQQEKTIEQFKPQTYFTISLSVESEKAKMTQKNPYALKER
QEAEQLVKELSKQKGLVTDIQEKVKTENAPLPYDLTEIQREANQRFQFSAKKTLSLVQSL
YETHKIVSYPRTDSKYLTTDMKGTMKERLQAIADFSPEVKGYLKNGAVVKQQKVFQNAKV
TDHHGLIPTEQRPRYEKLSNDEQKIYQMIVQRFLGLFAEPNQTKQTKVTVAFGKETFVFH
QNKVVVAGWKTTAEQPLSTVQWQKGMTVAPNFTINKELTSPPKPLTEGTLLGKMEKHSLG
TPATRAEIIEKLIKSELMERTNSGLSVSAKGKQLLDLVNPSLVTPELTEKWEKSLEAIAS
GQQKSQLFLKDIEEDTKKLVREIKQSEKKYQDFSITQKKCPDCGSNLREKNTKDGKIYVC
TNQECSYRRRKDPKVSNHRCPQCHKKMVIIEGKNGRSFKCKFCSITEKIPDKKERKQKMT
KHEERRLMKKYSQPDEPEESALAQALKAAMNQE
>Q8ABK5 ## B ## Bo ## Bacteroides.thetaiotaomicron ## DNA topoisomerase I (Omega-pro ## Bacteroides thetaiotaomicron ## DNA topoisomerase I (Omega-protein). ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Bacteroidaceae; Bacteroides.
MIAVIGEKPSVARDIARILGASEKQDGYLSGNGYLVTWAFGHLVGLAMPEAYGIQSFRRE
SLPIIPDSFQLTPRQVKAEKGYKADPGALKQLKVIKDVFDQSDKIIVATDAGREGELIFR
YIYNYIGCNKPFVRLWISSLTDKSIREGLQNLKAGSLYDNLFLSAQARSEADYLIGINGT
QALSVAAGQGIFSLGRVQSPTLAMICTRFLENKNFVPQKYWQLKLQAAKDNVSFAALSTD
KCDKQQPAIDTLQRIKEAETVQVKTVERKEVNQEPPLLYDLTTLQKEANTKLNFSADKTL
SIAQKLYEGKLISYPRTGSRYISQDVFEEIPERLVNLEQYTRFGGYAAGMKGKALNSRSV
NDGKVTDHHALIVTENLPDKMEADEQAIYELIAGRMLEAFSEKCVKDVTSVTLECAGSLF
TVKGSVIKSAGWRAVFGEKEDGEDNAALPAMQDGDSLPLSGIELLEKQTKPKPLHTESSL
LSSMETAGKELENADLKASMKDTGIGTPATRAAIIETLFSRQYIVREKKNLVPTEKGLTV
YNIIRDKKIADVEMTGMWENTLAKIESGEMNPDTFRKGIEVYARQITAELLDVQLSFVSG
SGCICPKCKTGRILFYPKVAKCSNVDCSVTIFRNKSDKQLTDKQITELVTTGKTGLIKGF
KSKNGKVFDASLAFDGQFNVTFVFPEKKGKPKK
>Q9L8Z2 ## B ## Bf ## Enterococcus.faecalis ## DNA topoisomerase III-like pro ## Enterococcus faecalis (Streptococcus faecalis) ## DNA topoisomerase III-like protein (EC 5.99.1.2). ## Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
MTYKLVIAEKPSVARSIAGVIGATEKHDGYLEGNGYLVSWCIGHLVSFADAGRYDERFKK
WRYEDLPILPETWQYIVPDDKKQQFDVLCSLMQRPDVTGLVCATDAGREGELIFRFVYQM
AGCQKPFERLWISSMEDSAIKDGFAHLKPGGDYDPLYQSALCRAKADWLIGINATRLFSV
LYHKNLTVGRVQTPTLKMLVDRDAKITDFKKEKYHIVHITAGGADAVSSRFSDAAEANTV
KAACAKAQAVCVSVTREKKTEQPPKLYDLTTLQREANRLFGYTAKQTLDYAQALYLKKLL
TYPRTDSQYLTDDMLPAVESLVSGLWELVPFAKGLNLSPQFDRILNSKKVSDHHAIIPTA
EFVKQGFGTLAESEKKLLSLICCKLLCAVAGPHIYEAVTATFTCAGQEFTAKGKTVLSPG
WKEIERRFRSSLKTDADEDAEAVRELPELCEGQTFADVAASVTEHFTTPPKPYTEDTLLS
AMERAGAEDMPEDAERKGLGTPATRAAILEKLVQMGFVQRKGKQLIPTKDGINLAVVLPE
ALTSPQLTAEWENRLTEIAKGQADPDEFMDGIETQARELVQTYSCISEEKQKLFQAERVP
IGTCPRCGEAVYEGKKNYYCGNRACQFVMWKNDRFFEERKKAFTPKIAAALLKTGKVKVK
GLYSVKTGKTYDGTVLLADTGGKYVNYRIEHRS
>Q8NWZ9 ## B ## Bf ## Staphylococcus.aureus ## MW1133 protein. ## Staphylococcus aureus (strain MW2) ## MW1133 protein. ## Bacteria; Firmicutes; Bacillales; Staphylococcus.
MTLADNLVIVESPAKAKTIEKYLGKKYKVIASMGHVRDLPRSQMGVDTEDNYEPKYITIR
GKGPVVKELKKHAKKAKNVFLASDPDREGEAIAWHLSKILELEDSKENRVVFNEITKDAV
KESFKNPREIEMNLVDAQQARRILDRLVGYNISPVLWKKVKKGLSAGRVQSVALRLVIDR
ENEIRNFKPEEYWTIEGEFRYKKSKFNAKFLHYKNKPFKLKTKKDVEKITAALDGDQFEI
TNVTKKEKTRNPANPFTTSTLQQEAARKLNFKARKTMMVAQQLYEGIDLKKQGTIGLITY
MRTDSTRISDTAKAEAKQYITDKYGESYTSKRKASGKQGDQDAHEAIRPSSTMRTPDDMK
SFLTKDQYRLYKLIWERFVASQMAPAILDTVSLDITQGDIKFRANGQTIKFKGFMTLYVE
TKDDSDSEKENKLPKLEQGDKVTATQIEPAQHYTQPPPRYTEARLVKTLEELKIGRPSTY
APTIDTIQKRNYVKLESKRFVPTELGEIVHEQVKEYFPEIIDVEFTVNMETLLDKIAEGD
ITWRKVIDGFFSSFKQDVERAEEEMEKIEIKDEPAGEDCEVCGSPMVIKMGRYGKFMACS
NFPDCRNTKAIVKSIGVKCPKCNDGDVVERKSKKNRVFYGCSKYPECDFISWDKPIGRDC
PKCNQYLVENKKGKTTQVICSNCDYKEAAQK
>P71196 ## B ## Bp ## Enterobacter.aerogenes ## TraE (EC 5.99.1.2) (DNA topois ## Enterobacter aerogenes (Aerobacter aerogenes) ## TraE (EC 5.99.1.2) (DNA topoisomerase). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Enterobacter.
MRLFIAEKPSVAKAIAGELGATGKGDGFIECGTDKVTWCFGHMLEQADPDEYTPDDVPRG
QSGKKVWRVDELPIIPESWILKPKDDAKKQLAVIGKLLKEAKEIVNAGDPDREGQLLVDE
VLEHFRNSKPVRRFWVSAQDSVSVKRGLAALKENTTYAGWADAARGRQRADWLIGMNLSR
AYTLRAQRGGSRALLTVGRVQTPTLALVVARDREIEAFKAVPYHTIRAVVQHAGGSFAAA
WKAKEDQAGLYSEGRLVDTAVADALVAAVKGQPGTIAAYKQEAKKQNQPLAFALSDITAL
ASAKFGYSAEDVLNTCQALYETHKLTCTRAPTAPTCRSRSTPTRRACWRRSSTSTPTGRP
GRWCRSAYQVQDVGRLEDHRAPRHRADHAEGQQGRPQRARAQHLRPDRARLPGAVLPAAR
VHADHRGRSRFAGENFAASGKVVTRNGWRDVYSQADEEGEKDEDDDSGTQALPSMAQGDA
VTCTDATRKDAKTKPPARFTEGTLIRAMENIHKFVSDAEHKKMLREGDGIGTSATRASII
SELKRREFLAVKGKQIISTTLGRSVIDALPEVVKSPVLTALYERMLKGVEQGTAALDAFI
TKQETFIRDQVAKANSGAVTIAGGKEAAPVSSLHKCMACGSGLSRRPSKKKGQFWWGCSN
FPTCKQTYPDLKGRPDYSKGRNGQASE
>AAR22322 ## B ## Bp ## Helicobacter.pylori ## Topoisomerase I. ## Helicobacter pylori (Campylobacter pylori) ## Topoisomerase I. ## Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
MNNSVIIIESPNKVAKIREITGAKVFATIGHFMQLKSYDESNGFKPTFDYDQEKKKHIFE
MIEACKNKKVYIATDPDREGYAIGYMFYQKIKNVASSIYRAEFFEITPSGINKGLQNALL
FENTNKQMYQSALARRVADMLLGFTLSPYLGKALGQMKGSSAGRVQTPCLKLIVDRDREI
EKFKALPENEKVSYQIQAKINDSANREVTIKHCDEKGEEIKFNDKEEALKLFESLKDNKA
CLLKDLKNSVVETKPKKPFITSTLLEKASSMLGLSISEVQSLAQNLFEAGLITYIRTDAE
SLSVEFLDETESFYAPIYNDLYLKREYKAGKQSQAEAHEAIRITHPHTTEDLESIVYNAN
ITNQDALKLYQLIFERTIESQGKNAIYDKQDLLFKIKNEYFKCSVKGLKSAGFLAMFSKK
ELENDESNDDKDNKEKEQNAQFNLKIDDVLSLNDLVLATIKRNAPSAYKEADFVKLLENK
GIGRPSTYASYLPTLVKREYISISQDKKHIITPTHKGKRVVEVFENAYQFIIDLTYTKQM
EEVLDEIVENKSSYVDFISNLNSKCPKIEKLERNDDEIKPSSEGQITYIENILRDLQLNL
SEEFKNYKEDNRVAKAFLDRYIKEHEFFKKNNKKASSSNNDENRPATPKQISFAEMLAKK
HNVKLPKGFKYSMKVCGDFINEYHKK
>TOP1_PYRHO ## A ## Ae ## Pyrococcus.horikoshii ## DNA topoisomerase I (EC 5.99.1 ## Pyrococcus horikoshii ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus.
MILIIAEKPNVARKIAGALSERRPIKKSLFGVPYYEIFREGKKLIVASAVGHLYGLAPKR
DVFGYPIFDIEWVPVYIAEKGKEYAREYIKALSVLAKRVREFIVACDYDTEGEVIGYTAL
KYACGVDPRVAKRMKFSALTKRDLLNAWRNLEPTINFGMANAGIARHILDWYWGVNLSRA
LTHAIKKASGKWVVLSTGRVQGPTLKFLVEREREIQSFVPRPYWVIKLIFEKNGQKFTAN
YEKDKIWEEEEGKRIVLEVKKSIPRVSNVEIKRQKRTPPHPFDLGTLQREAYSAFGFSPK
KTLDIAQSLYEKGFSSYPRTESQKLPRNINFRMIIQNLAKMPQYRPYAHILLGLPELKPV
EGKKEDPAHPAIYPTGEIPRPGDLTKDEEKLYDMIVRRFLAVFMEPAIRESVKVTIRAGP
HKFFLSGGRTVKKGWLSVYGKYVKFEEVTLPEFFIGERIKVIQVKREKKKTKPPARYSPA
AVIKKMEDLGLGTKATRAQILETLYQRGYIEGKKSIKVTPLGMKVIETLEKYVPEIISVE
LTREFEKKMELIMEGRLTKEEVIEEAKERLTKILEEFKKRELEIGIELAKIVVGEDEVKP
LVVGKCPKCGGDLIVKYNKKTGKRFVGCSNWPKCDVTYPILQRGEIIPTNKTCCNGAPVV
IIREEDGREFEICLDINCKDWKAKSH
>Q8PKG1 ## B ## Bp ## Xanthomonas.axonopodis ## DNA topoisomerase III. ## Xanthomonas axonopodis (pv. citri) ## DNA topoisomerase III. ## Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xanthomonas.
MRVVLCEKPSQGKDIARVLGAHRREAGCLGGPGITVTWGSGHLIEAAPPEAYGEHFQRWT
LPIVPPRWQWVVKARSAAQFKVVKRLLGEASELIIATDADREGEMIAREMIDYCGYRGPV
QRLWLSALNDASIRKAFGALRASSETLSLYHCALARSRADWLVGINLTRLFTLLGRHAGH
DGVLSVGRVQTPTLKLVVDRDREIAAFVPVPFWSIDVSLSAANVPFSAHWLAPRTATDDA
GRCLRQSVARHAADAIRAAGTAQVVHTETERVREGPPLPFDLSTLQEVCSRRLGLEVQET
LDIAQALYETHKATTYPRTDAGYLPENMLAEVPTVIQSLVKTDPALQPLIDRLDFRQRSR
AWNDAKITAHHAIIPTLEPADISAMSAKELAVYRLIRAHYLAQFLPHHEFDRTVVRFRCG
GETLQAVGKRIAVPGWQHAFSAPSLPHVAADGADTEGSDEAPREQMLPVLQEGISCQVSA
LDLKSLSTKPPRPYTQGELVKAMKTVARLVTDPRLKQKLKDTTGIGTEATRANIISGLLS
RGFLIRKGRAVRASDTAMMLIDAVPAAIADPGTTAIWEQALDMIEARQMGLESFVEKQAA
WVTQLVRQHLGTTLAIRSPEGPPCPLCGAATRQRTGRSGPFWSCSRYPDCKGTAPVAPAQ
AGPDGQKRSRSRGARAQR
>O25188 ## B ## Bp ## Helicobacter.pylori ## DNA topoisomerase I (TOPA). ## Helicobacter pylori (Campylobacter pylori) ## DNA topoisomerase I (TOPA). ## Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
MKDSVIIIESPNKVEKIKQLTGAEVYATIGHFTNLIGVDIENNFACKFEIKEDKAKKINF
LINACRDKKVYIATDPDREGYGIGYQFYEKIKNVASEIYRAEFHEITPSGIESGLKNAVL
FSRSNTNLYQSFLGRIASDQVVGFALTSYLRKSLNLSELSAGRVQTPALALICQRDQEIR
DFDKLDAEEKVEYQIQANIVCNEKEAIIKHVRANEKNELVDFKFKDKNEASQFLKDLKDG
LGSMSVLVSLKESLSNKEPKKPFTTSKLLSQASKSLKIPTKEIAQLAQKLFEAGLITYHR
TDSEFLSPEYLKEHEVFFEPIYPSVYQYREYKAGKNSQAEAHEAIRITHPHALKDLEKVC
SDAKISEELALKLYQLIYTNTICSQSRNALYNQYDCIFKIKSESFKLSFKLLKEKGFLEI
EELIQGKEEINREEQESEIENFSLKENDSVPLKEVFIKKIEKPSPKPYKESAFIPLLESE
GIGRPSTYASFLDLLLKRKYISIDTKTNAITPTSQGLEVISFFKKDKEVDFIALTSKDKS
KLGNTTKQFEECLDLIMRGEASYEKFMLEVISKLKSTAKFYQTQSTDNNMPTDKQLELID
KICKDKKLQKPSQEILQNKEKCSDWIAEHVKEKPSQKQLNLVKKICEECKLAMPTNKILN
DKFAISKWIDKHKKTKK
>Q9PPP9 ## B ## Bf ## Ureaplasma.parvum ## DNA topoisomerase I. ## Ureaplasma parvum (Ureaplasma urealyticum biotype 1) ## DNA topoisomerase I. ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
MQKDLIVVESPNKIKSIQSYLGDSYNVIATCGHLRELAKKSGYDPKTYDLKWEIIKTTNK
KLSKKQQIKTIIDLAKKSNNIYLATDPDREGEAISWHVYDLLPKKDKERVKRITFNEITQ
KAILKSIDEKHDIDFNLVDSQFARRILDRVIGYKLSGLVKKNLHGLSAGRVQSIALLFVV
ERELERRSFVKEEWYQIEGIIEKNIFVSLRKIPYDVELYNQKDNSDSDLKFLHKKDAQRV
IDDLSDIFKVYSIDDLKITKGDVQLPLTTDKLLQIASNNFGWSANKTTLIAQQMFEGLEI
NNQQLALITYPRTDSERLSDDFLQEANAFIENNFGKEYLENFKNKKINRKEVNIQDAHEA
IRPVDINLKPEEIKDYVSLDIYKLYNLVWNKTLSALMKVPTFNKQVIRFINNEYKFYTAY
KTIRTLGYWILDFYKKQRDELEFQPPIINVGDEFKKEKIDLIQKETTPPPYYTEASLIAA
LKNAGVGRPSTYATMATIGTTRGYINKDKSKLIPTELGIKVIQELKEAFPKVISIKFTSE
MEERLDVIANGKLFWKDLVSTFIPIFEEEVKQAYTKIEKVPDEKINRLCPICAHDLLIKR
SRMNTRFIACSNFPTCRFTESLEKPEILNELCPNCSKSLVKRKNRKNKYFIGCTGYPECN
FIRNLDESNNDKNDFNQ
>Q7N7S1 ## B ## Bp ## Photorhabdus.luminescens ## Similar to DNA topoisomerase I ## Photorhabdus luminescens (subsp. laumondii) ## Similar to DNA topoisomerase III. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Photorhabdus.
MKLFLCEKPSQGRDIAVVLGATKRGQGYLTGPGVTVTWAVGHLLETASPEVYGEQYGAPW
RASVLPILPASWQMVVKKETADQFTVICRLLKQADEVVIATDADREGEVIARELLDYCQF
QGKISRLWLSALDEVSIRAALANILPGEQTASLYLAGLGRARADWLIGMNFTRLYTVKAR
ECGYSDILSIGRVQTPSLALVVFRDREIIAFTAKPYWQVVADLQFDGRIFRADWVPAATY
CDEEKRCIHQNVAQTVVKLCQQTGTATVLEINTKREKHAAPLAFDLGSLQQLCSKKWSMG
AQQVLNIAQNLYETHKATTYPRTDCGYLPTAMQAEIPQVLDAVVKSDPAMRIVVDSLDRT
LISRIWNDKKITAHHGIIPTKQPCDMNKMTDDERKVYQLIRQHYLLQFLPLHEMDITEAT
FDIGGQLFRTRGNVVIVPGWKVLFSAGKDESASIGKDDSLGESLPSMVKGNQCQVNEATL
RMLQTQPSAHFTEGTLIAAMKNAAAFVSDPQLKKVLKDNAGLGTEATRAGVLDTLFKRGY
LTKKGKYIHATQIASELIAALPTALTNPGLTALWEQALDDIAQGQAELPDFMARQVQWTQ
YLVEQVQAQKVVITPPPSLPCPVCGGVTRQRQGKNGVFWGCIKYPECSGVVSTVDGKRKT
RSARHKNIPKKPAMTG
>Q7MXR3 ## B ## Bo ## Porphyromonas.gingivalis ## DNA topoisomerase III. ## Porphyromonas gingivalis (Bacteroides gingivalis) ## DNA topoisomerase III. ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Porphyromonadaceae; Porphyromonas.
MIVCIAEKPSVGREIAAVLGATKAYKGYMEGNGYQVTWTFGHLCALKEPHDYAPEWKRWS
ISSLPMIPLRFGIKLIDSDSIREQFGTIERLVHEADMVVNCGDAGQEGELIQRWVLQKTG
CTCPVRRLWISSLTEESIREGFARLRDSEEFHSLYEAGLARAIGDWLLGMNATRLYTLRF
GGNRQVLSIGRVQTPTLALIVRRQHEIEHFTPEVYWEVKTIYRDTVFNATKGRFSSIEDA
RREVEVVAGSPFAVTSVATKKGRELPPRLFDLTGLQVECNKRFAMTADATLRTIQSLYEK
KITTYPRVDTTYLSDDVFEKVPNILQGLSDYTLLTAPLRSSKLKKSKKVFDNSKITDHHA
IIPTGQPSHGMSEDERRVFDLVARRFIAVFYPDCIFSQTTVLGQAAKVEFKTTGKQILEP
GWRTVFTDPQTDDDGENKDEEKKLPIFSEGESGVHTPEVQEKTTQPPKFYTEATLLRAME
TAGKSVKDEELRDALKENGIGRPSTRAAIIETLFKRNYIYKEKKNLKATPTGMSLIATID
YDLLKSAELTGQWEYKLRRIERGDYSAADFINELKVLLTHLIPNVLKSNSSVLLSEPIPA
ASPAPGKKKKADKPMQKQLDLTCPVCGKGIIVRGREAFGCNAFREGCTFRLPYSEYPASL
SDNELVDLLSSQKGH
>TOP1_AERPE ## A ## Ac ## Aeropyrum.pernix ## DNA topoisomerase I (EC 5.99.1 ## Aeropyrum pernix ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales; Desulfurococcaceae; Aeropyrum.
MVAEKPKAAAKIAYALSDGRGVLRCSEYGVPYWIVRRDGAAIVVAPSAGHLFGPHTDSRG
FPVFDFEWRPIFEFDRGAGYLSKFYRMLSRILPGASLYVNACDYDIEGSVIGFKIIEAFG
DVNRARRMKFSTLAPQDIRRAYARMERLDVEMIEAGMARSEMDWLWGINVSRALMEAARR
AAGRRVILSAGRVQSPTLVEAYRRWREINLHVPKASVAVKITAEKGGGVFDARPHGWKPQ
SLETARSIKSELRKNPWLAVEEVRSERSILRPPPAFNLGDLQKEANRILGLPPLRTQSIA
EELYLEALISYPRTNSQKLPPSINYRAILDKLAHGPLGREARELLKETGGVLRPVQGSKD
DPAHPAIHPTGEKPSQRLSKEHMAVYELIVRRFLAAFSREAIVSKSSVLLRDFQGRVWRA
EGLRVEDLGWLKYYHYSTPGEKPMPPLDRGDKARVVRVDVRVEWSQTPVRLDKASLLRWM
ESVNIGTEGTRARIIETLYKRGYLEGSRKSEVTPLGEAVAVIIQTLFPELSKPDLTRRFE
SMIEDIRSGRRTRQEVIDMSKKTISKLLESFLDRLDTAVREIGVSLGSVEVEAACHLCGR
KAVSAVSGYRLCSHHMEAFDRLRKALPNLASTISSTPREALEAIARGRSRAGAWVRDVAA
LALRDDGLYKALL
>Q83L60 ## B ## Bp ## Shigella.flexneri ## DNA topoisomerase III. ## Shigella flexneri ## DNA topoisomerase III. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Shigella.
MANWCQRAAVVPWLRSVNLMRLFIAEKPSLARAIADVLPKPHRKGDGFIECGNGQVVTWC
IGHLLEQAQPDAYDSRYARWNLADLPIVPEKWQLQPRPSVTKQLNVIKRFLHEASEIVHA
GDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAIDRLRSNSEFVPLCVS
ALARARADWLYGINMTRAYTILGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDF
FEVKAHIVTPADERFTAIWQPSEACEPYQDEEGRLLHRPLAEHVVNRISGQPAIVTSYND
KRESESAPLPFSLSALQIEAAKRFGLSAQNVLDICQKLYETHKLITYPRSDCRYLPEEHF
AGRHAVMNAISVHAPDLLPQPVVDPDIRNRCWDDKKVDAHHAIIPTARSSAINLTENEAK
VYNLIARQYLMQFCPDAVFRKCVIELDIAKGKFVAKARFLAEAGWRTLLGSKERDEENDG
TPLPVVAKGDELLCEKGEVVERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKVLRATDG
LGTEATRAGIIELLFKRGFLTKKGRYIHSTDAGKALFHSLPEMATRPDMTAHWESVLTQI
SEKQCRYQDFMQPLVGTLYQLIDQAKRTPVRQFRGIVAPGSGGSADKKKAAPRKRSAKKS
PPADEAGSGAIA
>Q97ZJ8 ## A ## Ac ## Sulfolobus.solfataricus ## DNA topoisomerase I family A ( ## Sulfolobus solfataricus ## DNA topoisomerase I family A (topA) (EC 5.99.1.2). ## Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfolobus.
MNLCNVNNYYLIIAEKSKAAKKIAEALSEKPILCRKYNVSYWIIKDHNSSKYVIVPAAGH
LFGLKGESGFPVYDADWKPLWEIDKNSYYTKRYYQLISSLSKYALGFINACDYDIEGSVI
GYLIIKNLGDIKKAKRMKFSALTKSDILSAFRNISALDYDMINAGIARHKIDWLWGINVS
RALMISLQDFAKKRVILSAGRVQSPTLVQVVNSEIERNLFIPLPKFTVSIIVKIKDYSLN
IKVNKEFEKITEAKEFLNKLINKTVKVVEVENRVRLLERPSPFNLTDLQIEAGRIYGISP
YNVERIAEDLYLDGLISYPRTNSQKIPSTISIYNIIKGLENSSYRKLVDLVRKITGGKYV
VKQGIKDDPAHPAIHPTGEAPKNLPNSKFKIYDLIARRFLGSVSADAKLSNTIYTLKVSD
FPLEFTVSYTKILERNWLDIYHFHNVKEDKPIFLSKGDEGKIVDGKVNISLSKPTSRYTK
VSLLKWMESSNLGTEATRGRIIEILVKRKYLTNNGRYIIPTKLGFYIAEILNKFFPDIVD
VRMTADMESKLEMIKTGKVLESKVIKENIEKLNKFIEEYKVNKDKVGESLAKALGLIKIV
KCKYCDLEQYKDGLCKYHYEAKVRLLDAVEIWKERTKYDHKKILKRISSSKSTGKYVKDI
VTYMLSSE
>AAP58872 ## B ## Bf ## Spiroplasma.kunkelii ## DNA topoisomerase IA. ## Spiroplasma kunkelii ## DNA topoisomerase IA. ## Bacteria; Firmicutes; Mollicutes; Entomoplasmatales; Spiroplasmataceae; Spiroplasma.
MAQTLVIMESPTKTKAVEKYLGENYLVLSSEGHIRNLSTKGQYGLGVDIKTFEPSYKMER
GKKEIIKKLKQEAKAADLIILATDPDREGEAIAYHLNEVLNCGEKSRRVRFNEITKEAVL
EAFQHQTDLDMNLVHSQETRRILDRFIGFRLSKLLQKKIKSKSAGRVQSVALKLVVEREK
EWQNFVPEEYWTVEGLYKKAVVKLTKFKDYKIELKVEADVLKVKKALKKDFVVVQIKESE
KQRKSPNPHTTSTMLQEASSKMGFASNKTSLIAQQLYEGIKVKDNITGFITYPRTDSIRL
SDKFVQDAFDYITIKYGTEYLGGVKTQPKNKKNVQDAHEAIRPTDLTMTPEAAKEYLSRD
QIRLYKIIYNRSLASLMANAKLLSKAIILDNNNYEFRMTGSTIQFDGFLKCYFLEGNEEI
VKLPMLKPNQIINLNELYGIQHFTKPPSHYSEAKLIKTLEEIGVGRPSTYAPIMQTLKDR
GYIIVENKAIKATEKGILTSDKLQEYFSDIINETYTSTIEKSLDMIAHGDAEPKPLLKEF
WERFEPRIEATMELMEEIPVEKSGIECPECGNDLVYRYGKYGKFIACSGFPKCHYIHQTG
PKFGPCPECGVGEIILKFNKRRQRFKACTNYPNCNYTDSYKEEKTEQEENNSENNGLYRI
NLLK
>AAP83025 ## B ## Bp ## Salmonella.enterica ## Topoisomerase B. ## Salmonella enterica subsp. enterica serovar Paratyphi C ## Topoisomerase B. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella; Salmonella enterica.
MRLVLCEKPSQGRDIAKFLGATQRGEGFLNGPGVTVTWARGHLLETAEPEVYGEQYGKPW
RTDVLPLLPQQWKLVVKADAKAQFAVINRLLKQVDEVVIATDADREGEVIARELLDYCKF
QGRVFRLWMSALDDASIRSALADLWPSSRTESLYYAGVGRSRADWLIGMNLTRLFTLLGR
EAGIGNVLSVGRVQTPTLAIVVKRDREIDNFVSKPYFEVIATMAVNGVLFPSKWVPAAQY
CDEEKRCIQSGVAAQVVQLCRQTPTAAIINCQIERKKQSAPLAFSLSTLQQACSRHWGMP
AQTVLDIAQKLYETHKLTTYPRTDCGYLPLSMREEIPQVLSAVVGTDPALQPVVASLDTQ
FVSRIWNDKKITAHHGIIPTKHTGDLSKLSDAERNVYQLVRLHYLAQFLPQMEIDVTEAT
FNIGGQLFRTRGNVLVKPGWKSLFGKMSEDDEDNTGETTLPAMQAGQVCQVQGAEQKVLQ
TKPPAPYNDGTLIAAMTNAAAFVTDAALKKVLKENAGIGTEATRAGIIDTLLKRGFLVRE
KKTLKSTPLGRNLVDVLPGTLTNPGLTALWEQMLDEVAAGRVSLDDFMAKQSQWVSQLVA
QGRSQPLTMQAPPSPPCPVCGGKTLQRNGKSGLFWGCLKYPECKGIVNNGNKGPRGRRRK
PSPA
>Q972B2 ## A ## Ac ## Sulfolobus.tokodaii ## Putative DNA topoisomerase. ## Sulfolobus tokodaii ## Putative DNA topoisomerase. ## Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfolobus.
MNCYPKNYILVIAEKSKAAKKIAEALSDKPTTCKKYSVSYWVVNYKGKVNVVAPAAGHLF
NLYGDSSFPIFSMDWKPLWEIDDSAKYTKKYYNLLKDLSKYAIEYINACDYDIEGSVIGY
MIIKHFGDLKKAKRMKFSALTKQDIQKAYSNLSPLDYNMINAGIARHKVDWIWGINVSRA
LMLAVSSVTKKRVTLSAGRVQSPTLIHVVENEIARELYIPLPVYRVRVKIKIGNETFSLS
LNRTFEYKEEAQEFANKIKKSRAVVDEVRIEEKPLTRPSPFNLGDLQAEAGRILGYSPYY
VERLAEELYLDGLISYPRTNSQKIPPSVDIKSIVNGLEANFKNLVGLVRNITKGEYIVRQ
GSKDDPAHPAIYPTGNRITEKLGIKQYKLFELITRRFLASISRDAIMITQKIIIRFKDVD
ISDEITRQKIKFKGWLLLYPYHSVKDEELLDVKEGEEVKIESVSVKMDLAKPDVKRYNKV
QLLKWMETSNLGTEATRGKIIETLFNRKYLSQKRGTIYPTSLGIVIVEVLKDYFKDLTSI
ELTSKMEEKLNEILDGKETVEGVVAETINTLRIYLDNYNKYKDQIGIKLAKILGLMKYKK
CKFCDLEAEYDNLCKYHYNAYMKLKETLKVWKERTKLEDKDILKKIYSSKTTGKYIKDMI
SEMM
>TOP1_ARCFU ## A ## Ae ## Archaeoglobus.fulgidus ## DNA topoisomerase I (EC 5.99.1 ## Archaeoglobus fulgidus ## DNA topoisomerase I (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus.
MVMSWLIITEKDNTARRIASILFKDVKTLKKGRVSYYHSPSNDAYVVGLKGHIVELDFPK
ELNNWTKTPLEKLLQAELVKKVKERTISSILKEIAKKADRVTVATDYDREGELIGVEALE
IVKSVNPTVKVDRVRYSAVTEKEIRSAFSKPVKVDFNLANAALARQKIDLIWGATLTRLI
SVHSGRMGKDFLSVGRVQTPTLRLIVDRELEIQNFKPEKYYEIFAEFEGFIAKHPKRYGS
KEEAEKLFAKIGETAKVEEFTRRRMEENRPTPFNTTEFLREASKFMSPHKAMNIAETLYM
NGYISYPRTDNTVYPPTINLIEIVSALSSVFPREAQIVLSQDKITPSRGRRETKDHPPIY
PTGVAKRGELSKDEWTIYELVVRRFLATLAPKAVWDVRRVVLDSNGVKFVANGRQLVEAG
WRDIYIYSKAEETELPLLKKGDVLRILKKRLEEKETKPPGRYSASSLIKMMEKLNLGTKS
TRHEIIQKLVSRRYIHGNPFRPSETAFSVINVLKETAETITLPDMTAKLENEMDLIAEGK
KREPEVVDESREMLLQILRAIDYRKLSKDLREGVKKDKIVGKCPECGGELVVRQSKAGKR
FIGCSNYPDCTFTLPLPQNGTLYITAKQCKEHEIKEVKIRTKKGYWNLGCPYCNYLNWKK
ENS
>Q882Z4 ## B ## Bp ## Pseudomonas.syringae ## DNA topoisomerase III. ## Pseudomonas syringae (pv. tomato) ## DNA topoisomerase III. ## Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
MRLFLCEKPSQAKDIAAALGATRRGDGCWVGASATVTWCIGHLLETAPPDAYDARYKRWV
LEDLPIVPEKWKMLVKPRTASQFKAVKRLLGEANELVIATDADREGEMIARELVEHCRYR
GPIQRLWLSALDDASIRKALAALKPGADTFSLYHSALGRSRADWLIGMNMSRLFTLLGRQ
SGYQGVLPVGRVQTPTLRLVVDRDRSIADFVPAPFWAIDVKLLHENQAFIAQWRAPSDAC
DDQDRCLNQPLAQQAADAMRHAASARLVKLRTERMREAAPLPFDLGTLQEICSKKLGLGA
QETLDIAQSLYETHKVITYPRSDCGYLPNSQHGEAAGIITALGKTDPALAGLLPHLDPQR
RSRAWNDAKVTAHHGIIPTAAVRGVERLIGKPRAVYTLIRARYLAQFLPNHEYDRTQADF
DCAGQALRAVGKQIVEPGWKRAMPEALAPAKGREAPAPQPLPALFQGCECAVADVILKDL
WTQPPKPFTEGDLIKAMKNVAKLVEDPLLKQKLKDTTGIGTEATRAGIIQGLLDRGYLTK
QGKALCATPAAFSLIDAVPRAIADPGTTAIWEQALDMVQSGEMSLEEFVAKQAAWMSKQV
SRCVGMRMTISGPASPAGVAPPWKKKRKTAKRGAATSTKAANAATGTAAKKPRRAAKPTV
KG
>TP1P_XYLFA ## B ## Bp ## Xylella.fastidiosa ## DNA topoisomerase I, plasmid ( ## Xylella fastidiosa ## DNA topoisomerase I, plasmid (EC 5.99.1.2) (Omega-protein) (Relaxing enzyme) (Untwisting enzyme) (Swivelase). ## Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Xylella.
MKLMIIESPGKIEKLSTILGDGWKIAASVGHVRDLPQKEMGVAAPDFKPSYELTERGEGV
VAKLKNLLKQADSVYLATDPDREGEAISWHLQQCLKLSNPLRVTFNEITANAVKASLVAP
RTIDVKRVAAQEARRVLDRLVGYMVSPELSRLTGKRLSAGRVQSPAVRLVVEREREIKAF
KVTNHFGAMLFFADAKTSGEWSAEWLTKPKFVAEDNPYFMDRDFAAAVAQVKAVVVKSFD
ESEAKRSPPPPFTTSTMQQAASVTLGVDPKAAMDAAQKLYEQGHITYHRTDNPNVSDESL
GDIYAVSVKLGLDIAEKPRKFKAPAGAQVGHPAVTPTHWEVEEAGETSDQKALYKLIRLR
AIACQLADARYAVRTVRLEAAQPVGGKNVEFEARGRTLIYQGWLKLIAGDQTEEEDGNEK
ESSNPIPVCAPGECLDVARGKLLEKKTKPPSHYTQATLVKKLESEGIGRPATYAAIMDNI
VSRGYVKTEKKYLFPTETGELIVDSLVGKFEFLDLGFTREIEESLDRIAQGESGYKAVIA
KVHDQLNMELSTLQVSATPKHPCQECGKPLRRIPGKNGHFWGCSGYPDCSVTFPDEGGKP
GQKKPVEVSNFACVKCGNPLKHLVKKGKGGYDFWGCSGFKEGCKATYEDKKGKPNFEKAK

>TOP3_YEAST ## E ## Ef ## Saccharomyces.cerevisiae ## DNA topoisomerase III (EC 5.99 ## Saccharomyces cerevisiae (Baker's yeast) ## DNA topoisomerase III (EC 5.99.1.2). ## Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
MKVLCVAEKNSIAKAVSQILGGGRSTSRDSGYMYVKNYDFMFSGFPFARNGANCEVTMTS
VAGHLTGIDFSHDSHGWGKCAIQELFDAPLNEIMNNNQKKIASNIKREARNADYLMIWTD
CDREGEYIGWEIWQEAKRGNRLIQNDQVYRAVFSHLERQHILNAARNPSRLDMKSVHAVG
TRIEIDLRAGVTFTRLLTETLRNKLRNQATMTKDGAKHRGGNKNDSQVVSYGTCQFPTLG
FVVDRFERIRNFVPEEFWYIQLVVENKDNGGTTTFQWDRGHLFDRLSVLTFYETCIETAG
NVAQVVDLKSKPTTKYRPLPLTTVELQKNCARYLRLNAKQSLDAAEKLYQKGFISYPRTE
TDTFPHAMDLKSLVEKQAQLDQLAAGGRTAWASYAASLLQPENTSNNNKFKFPRSGSHDD
KAHPPIHPIVSLGPEANVSPVERRVYEYVARHFLACCSEDAKGQSMTLVLDWAVERFSAS
GLVVLERNFLDVYPWARWETTKQLPRLEMNALVDIAKAEMKAGTTAPPKPMTESELILLM
DTNGIGTDATIAEHIDKIQVRNYVRSEKVGKETYLQPTTLGVSLVHGFEAIGLEDSFAKP
FQRREMEQDLKKICEGHASKTDVVKDIVEKYRKYWHKTNACKNTLLQVYDRVKASM
>Q8GJE2 ## B ## Bp ## Campylobacter.jejuni ## TopA. ## Campylobacter jejuni ## TopA. ## Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Campylobacteraceae; Campylobacter.
MENTIIIIESPNKREKIEKITGAKVYATKGHFKSLSKNFLKEYENYEPIFDFSSDETKKR
MNAIFADCKNKDVIIATDPDREGYGIAYLFYEVIKNIAKSIKRAEFHEITESGINKGLKN
AVEFSKSNLNDFEAFKARIVGDKLVGFIMSPKYINKMNDKNISVGRVQTPALSLIVEREK
AIQDFLNDDNNKKLDYKIKAKLEKDGIVFYANNPNLYPNKEEALEKIESLRSKNAKLYTI
ETKKSEIKPAQPFRTSQFQEKANKIFGFAPDKSMALAQKLFEKGLITYHRTDSNALSVEF
LNEVEAFFKEKQWYQKREYKAGDQSQAEAHEAIRISHLHSFEDIEKIAREENLSDDEKNT
YTLIYLNSIQSQAKNAINEITSYDFNIGILSFKTNISKCIDKGFKGAFDFKEEDEKDEKD
DTQELELNIKEGEEIQVLDFELIEVKKQAPRRYKESNFISLLEKEGIGRPSTYASFLKTL
LDREYVELATKGKNKEIVATKKGISLIDFLNENDDEWITKSEFTKQMEEILDTISKGNLQ
YIDFIKPLHQKMEFIHIDDSDQIRKPSEKQIAFAEKLAKENNLELPKDYKENIKVCMDFL
EKAKENAKPLPASAKQIAFAEKLAKENNLELPKDYKENIKVCSSFIDEAIKKNKK
>Q7NLU9 ## B ## Bo ## Gloeobacter.violaceus ## DNA topoisomerase I. ## Gloeobacter violaceus ## DNA topoisomerase I. ## Bacteria; Cyanobacteria; Chroococcales; Gloeobacter.
MMRLLICESPGKIKTFKAILGAGWDVQASLGHVMELANDGADHLGFDVGPEAITCRYVPR
GERGMATLKKLRTAAAKAQEVYLATDPDREGEAIAWHLARELRLKSPRRIRCTQITEGAV
RTALQSPGRLDMDLVSAQRARQCLDKLVGYKVSPLLWNATGGKSAGRVQSATLHFVCERE
REIIAFVPVDYWSVWVEYAPGWRAYYQGDVQETPESTEATDDAKSNKEAPPAESTRVLSE
AEADRLVALARSHPHAVERVERRTVTKIPPAPFTTSTLQQAAGALLSYNPERTMGIAQQL
YEGIDLPTGRKGLITYMRTDSVEVAPEFVEQARTYLQINDPDNLPARSATHRSRAGAQQA
HEAIRPTDVSLTPRTIRAHLSEEQLRLYDIVWRRAVASQCAPARLAKTKILTRSGPVHWQ
ALGMTVAFAGYTRYWNDLEAALALPALEAGQNLELLRSAHEKKRTQPPPRYSEPKLVQLM
ERKGVGRPSTYASTIKTLKERAYVELQGRALVPTELGLATDALLGRTLPELVDSAFTARM
ETGLDAIAASREPWEKYLIGWNTDYLVPAVARARAAIAAEFPKRPAAPRTAQAPQISRTP
CPRCRQALSKVPSKKVKRGYFLKCPACADLVMFWNPWRKIWELPKPKTDPQTP
>TOP3_HAEIN ## B ## Bp ## Haemophilus.influenzae ## DNA topoisomerase III (EC 5.99 ## Haemophilus influenzae ## DNA topoisomerase III (EC 5.99.1.2). ## Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Haemophilus.
MRLFIAEKPSLARAIADVLPKPHQRGDGFIKCGDNDVVTWCVGHLLEQAEPDAYDPKFKQ
WRLEHLPIIPEKWQLLPRKEVKKQLSVVEKLIHQADTLVNAGDPDREGQLLVDEVFSYAN
LSAEKRDKILRCLISDLNPSAVEKAVKKLQPNRNFIPLATSALARARADWLYGINMTRAY
TIRGRQTGYDGVLSVGRVQTPVLGLIVRRDLEIE