>CAG18831 ## B ## Bp ## Photobacterium.profundum ## Putative Dihydrofolate reducta ## Photobacterium profundum (Photobacterium sp. (strain SS9)) ## Putative Dihydrofolate reductase. ## Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Photobacterium.
MGLDDRKRSEGCIYCGCFGYWTGNAWAIVLSSPVSGINLSIPKLAWVYGCYLRRYEVKIS
MIAAMAKDRVIGKDNAMPWHLPADFAWFKKSTLGKPIVMGRKTFESIGRPLPGRLNIVIS
RNPEFSVEGVTVVADIEAAKHAAGDIGELMVIGGGSIYEACLPSADRLYLTFIDLDVDGD
TCFPDWGEGWIKSYTEHYSADEKNAHDMQFVILERNVDLT
>DYR_BACSU ## B ## Bf ## Bacillus.subtilis ## Dihydrofolate reductase (EC 1. ## Bacillus subtilis ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNI
VVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYTDLFPYADRLYMTKIHHEF
EGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKKNSSKAGGF
>Q9BTM8 ## E ## Em ## Homo.sapiens ## Dihydrofolate reductase. ## Homo sapiens (Human) ## Dihydrofolate reductase. ## Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
MAARRQGPARSANPRPQFPGVCGREHAATLRAPGRGGGASPAQIGTRGRGGHNFAPNLTA
RSAVTSGLGGPPAAVMVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVE
GKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPE
LANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPG
VLSDVQEEKGIKYKFEVYEKND
>CAC84296 ## V ## Vdd_Herpesviridae ## Saimiriine.herpesvirus ## Dihydrofolate reductase. ## Saimiriine herpesvirus 2 ## Dihydrofolate reductase. ## Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
MVLLLNCIVAVDQNMGIGKKGHLPWPLLINDFKYFQRMTTSSVKNKQNLVIMGKNTWFSI
PEKNRPLKDRINLVLSKKLKEIPHGAHFLARSLNDALKLIEQPELVNKVDRVWIIGGSSV
YKDAMNYSSHLKLFVTRIMQSFETDTFFPEIDLKNYKLLIEYPGVPSNTQEEKGIKYKFE
VYEKIVNTFLFKSHAGLTCSVKPKEASYDFELS
>Q8ESB4 ## B ## Bf ## Oceanobacillus.iheyensis ## Hypothetical conserved protein ## Oceanobacillus iheyensis ## Hypothetical conserved protein. ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Oceanobacillus.
MDKKRKVKLFIATSLDGYIATKDESLQWLEDIEGEGDNGYLRFYEEIDTVIMGNKTYQWL
ESQNVNEFPYKGKDCYVFSRKESGRNENVIFVNDDVKRFIQMLQKKEGRDIWIVGGGELL
TSFIEQDLIDEYIITIAPIILGEGIPLFKECSSTINLSLIGTQKFNQFIELHYERTLTN
>Q8DUI2 ## B ## Bf ## Streptococcus.mutans ## Putative dihydrofolate reducta ## Streptococcus mutans ## Putative dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
MNNKREKKIVAIWAEDDRHLIGVKGSLPWHLPKELNHFKEMTMGQALLMGRVTFDGMNRR
VLPGRDTLILTHDPQFKAEGVSIVHSVPEALSWYRQQDKSLFIVGGASIYKAFESYYDKI
IKTSVHGQFEGDTYFPLRDFSSFQEISQAFFEKDENNSHDFTVTVLEKKE
>Q98I97 ## B ## Bp ## Rhizobium.loti ## Hypothetical protein mlr2503. ## Rhizobium loti (Mesorhizobium loti) ## Hypothetical protein mlr2503. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Mesorhizobium.
MDGTRERPMRKIIAATFVSLDGVMQAPGGPEEDPVGGFKFGGWTFHYFDEVGGAAMDELF
SKPFTLLLGRRTYDIFTAYWPYQKDPIADAFNPATKYVATHRPDTLTWQNTQWLGEDIVA
ALRRLSKQDGPDLLIQRSADLIQTLLANGLIDEIRLMIFPLLLGKGKRLFGDGAMPAAFK
LVKSQTSSTGVIIATYERSGEIEVGSFVMGEPSVAELERRRNWK
>AAS69448 ## B ## Bo ## Leptospira.interrogans ## Hypothetical protein. ## Leptospira interrogans (serogroup Icterohaemorrhagiae / serovar Copenhageni) ## Hypothetical protein. ## Bacteria; Spirochaetes; Spirochaetales; Leptospiraceae; Leptospira.
MRKITVLSFITLDGVMQAPGGPEEDTSGGFKYGGWTAPYEDEVSGKIMEKQMKPADYLLG
RKTFEIFASYWPEHADFWPGINEGTKYVMSKTVKKSDWKNSVFLESLADIKKLKNSEGSD
IQVWGSGELIQLLFKNDLVDELWLKIFPVTLNTGKRLFGDGIIPVAFTLIESSVTPSGVI
IANYKRAGEVKTGTVGA
>Q9Z7E7 ## B ## Bo ## Chlamydia.pneumoniae ## Dihydrofolate reductase. ## Chlamydia pneumoniae (Chlamydophila pneumoniae) ## Dihydrofolate reductase. ## Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae; Chlamydophila.
MCKNRGVRGIVACDPRGVIGLEGKLPWHYPEDLQFFSETIQKFPIVMGRKTWETLPRKYF
VDRAVVVFSHEKRQGVHGEIWVTSLEEFLLLDLSSPTFLIGGGELYSLFLENQIVRDFFI
SHIKKEYAGDTFFPLSLLETWTKTVLRDTQKITTCYYENHHSQNTKNISL
>Q39687 ## E ## Ep ## Daucus.carota ## Dihydrofolate reductase-thymid ## Daucus carota (Carrot) ## Dihydrofolate reductase-thymidylate synthetase precursor. ## Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae; Daucus.
MYKALISSTFPLLNSLSQTLALRSASLYLLTNCNLSSSNFSHCHRFTTYMASERLANPTN
GSGITRPDPQRTYQVVVAATQNMGIGKDGKLPWRLPSDMKFFKDVTMTTSDPLKRNAVIM
GRKTWESIPIQHRPLPGRLNVVLTRSGSFDIATVENVVICGSMISALELLAGSPYCVSVE
KVFVIGGGQIYREALNAPGCDAVHITEIEEHIECDTFIPLLDESVFQPWYSSFPLVENKI
RYCFTTYVRVRNSVAELTSQTNGCSSDSKSDSGNFEIQNFSFLPKTVFEKHEEYLYLGLV
ENIISNGVTKNDRTRTGTVSIFGCQMRFNLRKSFPLLTTKKVFWRGVVEELLWFISGSTN
AKILKEKGVNIWEGNGSREYLDSIGLTDREEGDLGPIYGFQWRHFGARYTDMHADYSGQG
FDQLLDVISKIKNNPDDRRIIQSAWNPSDLRLMALPPCHMFAQFYVANGELSCQMYQRSA
DMGLGVPFNIAAYALLTCMIAHVCDLVPGDFVHSIGDAHVYSNHLSDLFETSFRMLPKTF
PVLKINSGEKDIDSFEAADFKLIGYDPHQKIEMKMAV
>DRTS_TRYBB ## E ## Eo ## Trypanosoma.brucei ## Bifunctional dihydrofolate red ## Trypanosoma brucei brucei ## Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]. ## Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma.
MLSLTRILRKKIPVHELAGKISRPPLRPFSVVVASDEKGGIGDGGTIPWEIPEDMQYFRR
VTTNLRGKNVKPSPSKRNAVVMGRKTWDSLPPKFRPLSNRLNVVLSRSATKEQLLAGIPD
PIKRAEAANDVVAVNGGLEDALRMLVSKEHTSSIETVFCIGGGTIYKQALCAPCVNVLQA
IHRTVVRPASNSCSVFFDIPAAGTKTPEGLELVRESITDERVSTGAGGKKYQFEKLVPRN
SEEEQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCE
ELLWFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFGADY
ISCKVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVSNG
ELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCR
KQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV
>Q7NC38 ## B ## Bf ## Mycoplasma.gallisepticum ## FolA. ## Mycoplasma gallisepticum ## FolA. ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MRRYQFRKLWTPWPNQRKGSCLMIKLIVAMDEANLIGKKDKMPWHIKEEFEHFRKTTIGH
ALLFGKTTFLGLPGKLENRKHYVFSRKDQISNADETIRSEKELLELFKAYKDSQDILFIA
GGKYIYEHYYQYADELIISRIKNKYEGDVYLNLDLSNYFLMNVEENSKFTVEFWLKKSDN
NKTNANVISWDEYFMMLANVSAMRSKDPSTQVGACIVNKKKYVIGLGYNGMPKGLDNIFP
WDRTNQDSAKTKYPYVVHAEINAILNTSTVIEDCTLYTNLFPCSNCAKTIVQSGIVEVVY
EDNKYEHLPDNKISTHILKSSNIKLRQHKTRHKITEKDK
>NP_690426 ## V ## Vdd_unclassified ## Heliothis.zea ## dihydrofolate reductase ## Heliothis zea virus 1 ## gi|22788718|ref|NP_690426.1| dihydrofolate reductase ##  Viruses; dsDNA viruses, no RNA stage; unclassified dsDNA viruses.
MGICSVYLYSCVHVVYIVCINFVYILHQPSCTIVIRYPFFRHPQMSNFGLFKLFKGSPLK
LNKPKMLNTPKMLTINITYPPKPKVPINLIVAVCENNMGIGMNNALPWHLKREMAHFTKT
TTTATHPNKNAVIMGRLTWESIPKRFRPLPGRVNIVLTTKHRGDYDGATRVSNFDEAIRV
VESRGDIETAWVIGGASVYAAAMTHPNCHQIHLTAIKKYYECNVFFPKIDTTRFELISET
PCTREGDVQYSYKVYQQRNTHASI
>DYR_HELVI ## E ## Em ## Heliothis.virescens ## Dihydrofolate reductase (EC 1. ## Heliothis virescens (Noctuid moth) (Owlet moth) ## Dihydrofolate reductase (EC 1.5.1.3). ## Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; Noctuidae; Heliothinae; Heliothis.
MSQVKLNLIAAACDNMGIGVNGALPWRLKKEMAYFTTMTSKVSEPTKVNAVIMGRRTWDC
IPDKYRPLQDRVNIVLTHNVDSVKENVPEGVMVFPGLDEAIKYIEGREDIESTWVIGGSS
IYRAAMTHPNCGKIYLTEIQKSFDCDTFFPNIDKQQFHLVDEEQIPGEKQVEGNISYYFR
VYKKL
>CAE77979 ## B ## Bp ## Bdellovibrio.bacteriovorus ## Putative secreted protein. ## Bdellovibrio bacteriovorus ## Putative secreted protein. ## Bacteria; Proteobacteria; Deltaproteobacteria; Bdellovibrionales; Bdellovibrionaceae; Bdellovibrio.
MTNCRVSKPRNGLKIRALQGGPMRTITVFNSVSLDGYFADKISDMSWAHNQEQDDEFTAF
VAGNAKGGGALLFGRKTYDMMASFWPTPSAKEAMPEIAEGMNRMKKYVVSHSLNEVTWEN
SELIKGDLVSEIRKLKKQNGPDIAILGSGSIVAQLAEAKLIDEYSVVVLPLLLGSGRSQF
EGLKSRRDLKLVECRSFKNGNVFLRYRPADIHDDLH
>CAG27847 ## B ## Bp ## Morganella ## Dihydrofolate reductase type V ## Morganella sp. TR-90 ## Dihydrofolate reductase type V. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Morganella.
MVAISKNGVIGNGPDIPWSAKGEQLLFKAITYNQWLLVGRKTFESMGALPNRKYAVVTRS
SFTSDNENVLIFPSIKDALTNLKKITDHVIVSGGGEIYKSLIDQVDTLHISTIDIEPEGD
VYFPEIPSNLGQFYQDFASNINYSYKSGKGLQVAATDRNLSRLCTKAAPGCDPLCSVRLH
EIVHYEANAPWIGRMNAQTQSVGRKLLPGNRAA
>AAN41422 ## B ## Bo ## Gamma-proteobacterium.Hot ## Dihydrofolate reductase. ## Gamma-proteobacterium Hot 75m4 ## Dihydrofolate reductase. ## Bacteria; environmental samples.
MKISLISATSENGVIGNGPDIPWSAKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSRKGISSSNENVLVFPSIEIALQELSKITDHLYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDINFPKIPENFNLVFEQFFLSNINYTYQIWKKG
>NP_861932 ## V ## Vdd_Caudovirales ## Enterobacteria.phage ## Frd dihydrofolate reductase (p ## Enterobacteria phage RB69 ## gi|32453723|ref|NP_861932.1| Frd dihydrofolate reductase (product is methyl donor used by dTMP synthase; similar to T4 accession AAD42577) ##  Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae; T4-like viruses.
MLKLVFACAPSKTVDDKLEYAFGLGDGLPWKHIKQDMSNFVARTKNTVMVMGAKTFASLP
RLLPDRTHMVVTDMARKLPRTKTDELARFYITQAEFITLVMGGEINLFSPSTDVPFKLST
EHVDVSVIGGPALLKQALPYADEIVMTKIIKKCRVNSDVQLDKDFVQDIMLQRSMVESHY
YRIDELTEITESVYK
>Q9F3L2 ## B ## Ba ## Streptomyces.coelicolor ## Hypothetical protein SCO5252. ## Streptomyces coelicolor ## Hypothetical protein SCO5252. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MRKLTYFVACSIDGFIGGPDGDASFMVPFVDEEFFEFLKSEYPETLPTHGRRPLGIDDLP
NKRFDTIVQGRASYDLALKEGVTSPYAHLREYVASRTLTESPDPNVEIISTDLVGRVREL
KAEDSAFGIYLCGGSAVAGELVDEVDELVVKTYPVVLGTGMPMFGSGFEVSAFVPDSVRT
FGNGVVVRTYHRKR
>CAF19426 ## B ## Ba ## Corynebacterium.glutamicum ## Putative dihydrofolate reducta ## Corynebacterium glutamicum (Brevibacterium flavum) ## Putative dihydrofolate reductase. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
MMAIIYNTSSTLNGFIADKDNSLQWLFDVPGSDGASEDFGNFLSKAGTIVMGSTTYEWLL
KDLDFISDPHKWTDVYGDRPTWVFSSRNLETPEGKPVKVVNGDVADVLPAILEESPENTD
IWIVGGGDLAGQFFDAGALDRIILTMAPVFLDEGQPAMPRRIESNRLRTVNVREVGQFTE
ITLETIKGA
>Q8MTJ0 ## E ## Em ## Haematobia.irritans ## Dihydrofolate reductase. ## Haematobia irritans exigua (Buffalo fly) ## Dihydrofolate reductase. ## Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea; Muscidae; Haematobia.
MLKFSLIVAVCENFGIGIKGDLPWLLKSELKYFSTTTKRVHDPSKRNVVIMGRKTYFGVP
ESKRPLQQRLNIVLSTTLKQSDLPKDVLLYPNLESAMSFLENEKDINQQIETVWIVGGSG
VYKEAMASPRCHRLYLTKIYAKFDCDTFFPDIPADFKEVDLDPETPKGIQEENNITYEYK
ILEKQDHK
>CAE49340 ## B ## Ba ## Corynebacterium.diphtheriae ## Putative folate reductase. ## Corynebacterium diphtheriae ## Putative folate reductase. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
MLRAIWAQSTDGVIGDGNDMPWHVPEDLAYFKATTLGEPVIMGRTTWTTIPERFRPLPGR
RNFVLSSRAPGAWSTGAEVVTAIPELDCDAWIMGGGAVYTSTLPLVDEVVITLIDVTLAP
VLGDAAVYAPALDDSFEVVEESPWQQSASGTVLGTPARYKFQRLRRR
>DYR_BUCBP ## B ## Bp ## Buchnera.aphidicola ## Dihydrofolate reductase (EC 1. ## Buchnera aphidicola (subsp. Baizongia pistaciae) ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
MNISIIVAMSQNLVIGQKNSIPWNIPKDLSWFKKHTIKKSIIMGRKTWESIGRVLPMRQN
IVLTRQKNIKNTNVLFVNSISKAIQSALYKNEIMIIGGSNLYNQMLTSANKLYITHIEKY
ILGDTYFPTYDHLPWKIIFKKKIIEHEKTKNSFYVTFKILKKIT
>Q8A638 ## B ## Bo ## Bacteroides.thetaiotaomicron ## Dihydrofolate reductase. ## Bacteroides thetaiotaomicron ## Dihydrofolate reductase. ## Bacteria; Bacteroidetes; Bacteroides (class); Bacteroidales; Bacteroidaceae; Bacteroides.
MSKISIIAAVDRRMAIGFQNKLLFWLPNDLKRFKALTTGNTIIMGRKTFESLPKGALPNR
RNVVLSTRPDTVCPGAEVFPSLEVALQSCKEDEHVYIIGGASVYQQALPLADELCLTEIN
DVAPEADAFFPEVSPAQWHEKSREAHPVDEKHLCPYAFVDYVKQ
>DYR_MYCGE ## B ## Bf ## Mycoplasma.genitalium ## Dihydrofolate reductase (EC 1. ## Mycoplasma genitalium ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MLIAIWAMTQEGLIGNNNTLPWMIKQELAHFKKTTLFQALLMGRKTYESLPKVFEKRTIF
LLSKDQNYRFEEKGSEVKVINDFWPLIKSYQANKEKDLFICGGKSVYEQTINECDQLIVS
IIKKKYKGDQFLKVDLSKFVLNEVVEFEEFNVNYYRKKQQ
>Q7RW41 ## E ## Ef ## Neurospora.crassa ## Hypothetical protein. ## Neurospora crassa ## Hypothetical protein. ## Eukaryota; Fungi; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariales; Sordariaceae; Neurospora.
MSHMYFQPDAVKAAHYIQQLDDARCEENWDAVPELVRKVRKHAPDRICLTLTAEIELAIT
RACQKAAPQDTDRPSTAGGPAVGIEVASHIPNLITAIENETQHPEESFQAKVCLGWLHWV
MKDYPIALVRLPKNFDLEYPQCDNLDTLSEWTKVCALKSTYLRANCLARDGQRDLAMAAF
EAALPSLSSVWTTKTARHQLRYWAELFLTEHCMLASQAIRENDELLSDPNCLASFRTWSK
YWASTKGQPLAGGYGFRGSVPRRQVWSEYYHVLSELLQRDLPFPTGYSEPSNDSSARSQL
RAELKKVEIIFQGLLYTETKFPRADEQRTEVEQFVDRVMQNWIILNGHGWKEQDLVHLAV
AEFDLAFAAFDSYLDIIKKSKARVAKTGHLEPALDDDATMLETISACIAALCRFGGRDAA
EKAHHLGLQLENLLERLTNGKVSAEENLNAAKDGHLVLTAAELLPPRALALTYQAAGLAN
AQWARMTYDSESRTHFQQKAVHCLSKSLSPELGLGVDVRGVFALGTLLAEQRNLHYAISL
VKTALLEDVDIDESQELYRGPCWRERSLIPLWHLLALMLSAQEDYVMAARACEGAMEQFK
DPFILFGTRSLNGAYQSEHLNEAGVEDGSYTSQGIVDEMDDFEKESLLEIKMTQLAILEL
VEGPTVAVNASSELLTLFTRLFGDLDQKVELTKPELPRTATTAVAKEQTRNRRASVFGSR
SVRSGRGMRQSIFGSHDKNLTGIPPVPQAPGAPAIQVTNNENAQSKRKSHSLSRSASGRR
HSLRRKSRSESQGAIEAPPPMPVNGSLADYAGKDGAAAAPPPEEPSIDGVQRTNSFDSNE
EYNDGEASVLAQVYGSLLPVIHFSQEHSKRKRKAILIKVWLTIAGFYRRAGLVADAQQAC
TEAQTIVEALEAEILNDTTGDVSLREAGWGETKSTEELYADVWAEKGYLSVACGKPYEAR
ADFETALMHFPDHAAAIVGLSDILLDIYSEKLLPPPVVPSFNLEDSILSDNSTPLQAITK
SPELRLQPLGLSTAKMESKLDKGEDNLENGMAALKLKGVSSPNKCPELPPPHKATSLPLH
DRLTARDRAYGLLSGLTKLGTGWNNSEAWFTLARAYQESGQVDKAKGALWWCVELEDGRG
AREWTCVDAGGYGKEVAEKDRRGWETETKNMSAILPSIELTLVLAATRDMGIGLNGGLPW
TGLKKEMAYFARVTKRLPSQLAGTKALNAVIMGRKTWESIPPKFRPLKGRLNIVISRSVT
SSPSLSSPSSSSSSSSEVEEGPVMASSLEQAIEYLHHCQQQQQQQQQQQQQEQQQKVGKV
FVIGGGQIYGAALKLPKELKEEGEASGSEEWVRKSKEELDQFVGEEVPEGLQVENGTEYE
FQMWERR
>DRTS_PLAVI ## E ## Eo ## Plasmodium.vivax ## Bifunctional dihydrofolate red ## Plasmodium vivax ## Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]. ## Eukaryota; Alveolata; Apicomplexa; Haemosporida; Plasmodium.
MEDLSDVFDIYAICACCKVAPTSEGTKNEPFSPRTFRGLGNKGTLPWKCNSVDMKYFSSV
TTYVDESKYEKLKWKRERYLRMEASQGGGDNTSGGDNTHGGDNADKLQNVVVMGRSSWES
IPKQYKPLPNRINVVLSKTLTKEDVKEKVFIIDSIDDLLLLLKKLKYYKCFIIGGAQVYR
ECLSRNLIKQIYFTRINGAYPCDVFFPEFDESQFRVTSVSEVYNSKGTTLDFLVYSKVGG
GVDGGASNGSTATALRRTAMRSTAMRRNVAPRTAAPPMGPHSRANGERAPPRARARRTTP
RQRKTTSCTSALTTKWGRKTRSTCKILKFTTASRLMQHPEYQYLGIIYDIIMNGNKQGDR
TGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWE
ANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHDNYEDKGVDQLKNVIHLIKN
EPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASY
SIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIED
FTISDFTIENYVHHDKITMEMAA
>DRTS_TOXGO ## E ## Eo ## Toxoplasma.gondii ## Bifunctional dihydrofolate red ## Toxoplasma gondii ## Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]. ## Eukaryota; Alveolata; Apicomplexa; Coccidia; Eimeriida; Sarcocystidae; Toxoplasma.
MQKPVCLVVAMTPKRGIGINNGLPWPHLTTDFKHFSRVTKTTPEEASRLNGWLPRKFAKT
GDSGLPSPSVGKRFNAVVMGRKTWESMPRKFRPLVDRLNIVVSSSLKEEDIAAEKPQAEG
QQRVRVCASLPAALSLLEEEYKDSVDQIFVVGGAGLYEAALSLGVASHLYITRVAREFPC
DVFFPAFPGDDILSNKSTAAQAAAPAESVFVPFCPELGREKDNEATYRPIFISKTFSDNG
VPYDFVVLEKRRKTDDAATAEPSNAMSSLTSTRETTPVHGLQAPSSAAAIAPVLAWMDEE
DRKKREQKELIRAVPHVHFRGHEEFQYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYS
LDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHR
EVGDIGPGYGFQWRHFGAAYKDMHTDYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAA
LDEMALPPCHLLCQFYVNDQKELSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKP
KEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVP
HGRIQMEMAV
>DRTS_PLAFK ## E ## Eo ## Plasmodium.falciparum ## Bifunctional dihydrofolate red ## Plasmodium falciparum (isolate K1 / Thailand) ## Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]. ## Eukaryota; Alveolata; Apicomplexa; Haemosporida; Plasmodium.
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFRA
VTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKLQNVVVMGRTNWESIPKKFKPLS
NRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIK
KIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNKMLNEQNCI
KGEEKNNDMPLKNDDKDTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKE
EKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKF
DLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFH
REVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVK
DLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQP
AQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHE
KISMDMAA
>SCPA_MYCGA ## B ## Bf ## Mycoplasma.gallisepticum ## Segregation and condensation p ## Mycoplasma gallisepticum ## Segregation and condensation protein A. ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MSNKLTIMIKLIWCEDLNHGIAKNNQIPWKIDEELNHFHQTTTNHPIIMGYNTYLAMNKI
LANQANIVISKKHQRELKNKNELFLYSDLKKALIDFSIVDLFIIGGKKTIEQAIKYADQL
VISKLNADYGCDLFVNLNYDDFSLVQTKEYDQFVVEYWERKPNTKKPEDLIEELNINLND
DFLNLSFKHFSGPFDLLLHLIKDKKMDIMALDLFELTNQYFAYINKHMINLDLVSDYLYM
ACELLRIKSDLSIPNFEDETKIDLNNDDERDRIVKRIIEYKRYSELLPSLQKMQLERFSL
FAKEEDDWDVFKLTSNDLLEAPLPDYVNPKKLKKAMERVFEKLKIKTITEHKIVIEELSI
EDVKNEILSIIKKLLNNQYDRFIDLEKIFEQIDPKKLNLRYFVTSFVCLLILVREQKIDL
NQKNDDESISACLVDPTKIVNSQESIQEVIQRQQEDEKALKESIKQIQEERKQSFFKQRE
EYLKKKYGEYYVSREQYQKLTPEEKINIRINQRKIDEQEKLNKAKAQNLVDENNQIIDLK
TKKPSAKQILYEADLIIKQLDDLINDQQEDYDSQAELEALHTDLIKLDDEQEQDLIKEE
>MIMI_R497 ## V ## Vdd_Mimiviridae ## Mimivirus ## 662068..663759 Thymidylate syn ## Mimivirus ## 662068..663759 Thymidylate synthase ## Viruses; dsDNA viruses, no RNA stage; Mimiviridae.
MKKFNIIAAINNDSIIGVKEYGTFSMPWPYLKDDMNHFRKITTDTGSIESGVNAIIVGFN
TWQTLPSSYRNIRSRFNIVISRDDETDGQFHKYVKTFDEAIEFASSLTNLNEIFVIGGGV
IYDLALKHKLLDKLYLTHVGSNYPIDDNVEKVVHFPLTWSKIEKMCDSNFLELDSEISKH
DIGKNILLRFQEYSVKKELYWAIEYLKKNTSLDNKGIIGDKGATGSKGYSLEQHDYYSTE
YFWNFYEFITRKVFDLFNSSNEISIPSEECPENQYIELVKTIMEKGIVKQTRNSITKSIF
GYQLKYDLSKGYPIQTIKRSYPKAIFEELMWMIRGQTDVSILQKKGVHVWDKNSSKDFLS
KYNLPYEEGDIGPGYGFQMRYWGAEYTDCKTSYQGQGIDQLNKCIESIQNNPHDRRIMIN
LWNCSDLDKMALAPCHFCYMFGVDLYEVPTTSGKKGRLNCHLVQRSWDVLLGWNTTTAAL
LTYLIANHCDLDPGILVHSISDAHIYQSHIDSGAISQLLQRKCRKFPNLVIRNKKEKIDD
YEFDDLIIENYYPCPSISAEMIA
>Q27552 ## E ## Eo ## Cryptosporidium.parvum ## Bifunctional dihydrofolate red ## Cryptosporidium parvum ## Bifunctional dihydrofolate reductase-thymidylate synthase. ## Eukaryota; Alveolata; Apicomplexa; Coccidia; Eimeriida; Cryptosporidiidae; Cryptosporidium.
MSEKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWD
SIGRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYR
DALKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQEK
KTLQNCDPARGQLKSIDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQY
LDLLSRVLENGAYRENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIK
GDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDY
TGVGVDQLAKLIETLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNL
YQRSCDLGLGSPFNIASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRT
PRPFPQLKFKRKVENIEDFKWEDIELIGYYPYPTIKMDMAV
>Q7Z0Z9 ## E ## Eo ## Babesia.bovis ## Dihydrofolate reductase/thymid ## Babesia bovis ## Dihydrofolate reductase/thymidilate synthase. ## Eukaryota; Alveolata; Apicomplexa; Piroplasmida; Babesiidae; Babesia.
MSTVYEGCGGLTIYVAIALNRVIGHQNQIPWPHIIHDFRFLRNGTTYIPPEVLSKNPNIQ
NVVIFGRKTYESIPKASLPLKNRINVIISRTVKEVPGCLVYEDLSTAIRDLRANVPHNKI
FILGGSYLYKEVLDNGLCDKIYLTRINKEYPGDTFFPDIPDTFEITAISPTFSTDFVSYD
FVIYERKDCKTVFPDPPFDQLLLKGVDIIVPKPKYVACPGVRIRNHEEFQYLDILADVLS
HGVLKPNRTGTDAYSKFGYQMRFDLSRSFPLLTTKKVALRSIIEELLWFIKGSTNGNDLL
AKNVRIWELNGRREFLDKNGFTEREEHDLGPIYGFQWRHFGAEYLDMHADYTGKGIDQLA
EIINRIKTNPNDRRMIVCSWNVSDLKKMALPPCHCFFQFYVSDNKLSCMMHQRSCDLGLG
VPFNIASYSILTAMVAQVCGLGLGEFVHNLADAHIYVDHVDAVTTQIARIPYPFPRLRLN
PDIKNIEDFTIDDIVVEDYVSHPAIPMAMSA
>SCPA_MYCPN ## B ## Bf ## Mycoplasma.pneumoniae ## Segregation and condensation p ## Mycoplasma pneumoniae ## Segregation and condensation protein A. ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MITLIWCQDKHFGIGRDNTIPWKLTEANQHFYNTTKNQTVVMGYNTFQELGDKLTDHNVV
VLSKKHFEELQNNTNIKVFNSIEKLLQHHFNRDLYVIGGKQIFHHFIELADRLIISVLPV
DFKCNLRLKLGLDSFELMQEQQHSQFKVQYWHKKHPERLSFNVFLEDYNGTLPNLLELLI
DKKFNLHQVDIAKITTQYLHLINTNLNKQAIEPITDYLVITSRIVEQKANNLLQINDIAL
DSDFLDNKLRDKLVAQLVEYKRYRESLDDFEKLRINRLAYFSKDNDFNRFIQTVDKSNTE
PVKIEDELPNYVSVLKLHHAMNKLMQRWRAQFLANKNISIQELSIEQVQAEILATIKQFG
YHSVSLKRVLLKVNHHISLMYFITAFVALLVLINNQIIDIEQTSFDDELYICLLDSSRIE
QLQETPEAMVERAVKQRQEAQELARQVAREKAIANAQKREAYLKAKYGKDYLTREQFLKL
SPEERAAHVAKMKQLKLVKNDNGRDN
>SCPA_MYCGE ## B ## Bf ## Mycoplasma.genitalium ## Segregation and condensation p ## Mycoplasma genitalium ## Segregation and condensation protein A. ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MISLIFDKSNSFNPQLCVELLNHFKVVMLTKTIVVDYPSFQAWKAQLKPFKLAVFSDNLQ
TELTPNSKLTVFNNYQQLLVDNNDLIIFATPTLVQLFDNEIDQLIVINPTSKSKDQFNCN
WNDFVLIKQTNFKNHQVGYFDKKSSYEPPFTVVTDHFFGNLTDLFSLLVDKKVSVNDVDI
GLISLQYLNIIANYTNKKAIEKITDYLVITSKILAKKADNLLNDHQEESVLEYDLATNNF
RDKMIANLVEHKRYCDSLGEFEKLRVNRLAYFSKANEMEQFIKTANDQLVTVEDQLPNYI
SVLKLFHAMNKLLEMRLSSLLTNKNITIKELSVEQVQKELVLAIKQFNYQTVSLKRVLLK
LNHPISLMYFVTAFVALLVLLNNQVIGLEQKDYHSELYIFLLDENQLKTFQESPDEMVKR
IQAQQQQNELIIAKNKQLRAIKNKQKRADYLKKKYGENYLDKTNLKDENNN
>DRTS_PARTE ## E ## Eo ## Paramecium.tetraurelia ## Bifunctional dihydrofolate red ## Paramecium tetraurelia ## Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]. ## Eukaryota; Alveolata; Ciliophora; Oligohymenophorea; Peniculida; Paramecium.
MTTNKTFSMVLAMTLNGGIGYQNRLPWKLKEDLQRFKKITTGGIVIMGRKTFESMNSKPL
PNRVNVVISKNMKSSNEVQVFPRIEDALQFYNTSHQKLYLIGGKRIFEEGLATDKCSDVH
LTRIGVETKCDVYLNKNIFSTFQVNKTSQTKSENGINYDYQHLINKNSHEQSYIDEEHQE
NQYLDMITKIMKEGVSKDDRTGVGTMSIFGQTMRFNLAQSFPLLTTKKVFFRGVVEELLW
FLRGNTNGKLLLDKGVKIWEGNGTREYLDTIGLQHRQEHDLGPVYGFQWRHFGAKYKDCQ
TDYSNQGVDQVKEIIQLLKNNPDSRRIILSAWNPIDLKQMALPPCHVMSQFFVANGKLSC
MMYQRSCDFGLGIPFNIASYALLTYMLAKECNLNLGEFVHVLGDTHIYSNHVEALKKQIE
RVPYPFPLLKIKGNKSLFDYTYEDFELVGYNAHDKIEMKMAV
>DYR_SCHPO ## E ## Ef ## Schizosaccharomyces.pombe ## Dihydrofolate reductase (EC 1. ## Schizosaccharomyces pombe (Fission yeast) ## Dihydrofolate reductase (EC 1.5.1.3). ## Eukaryota; Fungi; Ascomycota; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
MSKPLKVLCLHGWIQSGPVFSKKMGSVQKYLSKYAELHFPTGPVVADEEADPNDEEEKKR
LAALGGEQNGGKFGWFEVEDFKNTYGSWDESLECINQYMQEKGPFDGLIGFSQGAGIGAM
LAQMLQPGQPPNPYVQHPPFKFVVFVGGFRAEKPEFDHFYNPKLTTPSLHIAGTSDTLVP
LARSKQLVERCENAHVLLHPGQHIVPQQAVYKTGIRDFMFSAPTKEPTKHPRDLTMIVAV
SSPNLGIGKKNSMPWHIKQEMAYFANVTSSTESSGQLEEGKSKIMNVVIMGRSCYDSLPK
KNRPLKDRINIVITRNSNYNFGLTKKEKMPENLYAADCIDSALDLVAEKYGADSDIQVGK
VFIIGGSFLYGSALYHPLTKNLLFTRIHKEYPCDSFFPFEPAESSDWVRKAHPELEKFVG
IPVEEGRLKAASSNKEEVEIEFELYGKNDDVNVALEKLSIC
>DYR_CRYNE ## E ## Ef ## Cryptococcus.neoformans ## Dihydrofolate reductase (EC 1. ## Cryptococcus neoformans (Filobasidiella neoformans) ## Dihydrofolate reductase (EC 1.5.1.3). ## Eukaryota; Fungi; Basidiomycota; Hymenomycetes; Heterobasidiomycetes; Tremellomycetidae; Tremellales; Tremellaceae; Filobasidiella.
MQTTAKSSTPSITAVVAATAENGIGLNGGLPWRLPGEMKYFARVTTGETPSSDPSEQNVV
IMGRKTWESIPSRFRPLKNRRNVVISGKGVDLGTAENSTVYTDIPSALSALRSTTESGHS
PRIFLIGGATLYTSSLLPSSVPSLNSSTSTSPLPFSRPLIDRILLTRILSPFECDAYLED
FAAHTKPDGSKVWKKASIKEFREWIGWDIEEQVEEKGVKYIFEMWVLNQ
>Q8UG28 ## B ## Bp ## Agrobacterium.tumefaciens ## DNA-binding protein. ## Agrobacterium tumefaciens (strain C58 / ATCC 33970) ## DNA-binding protein. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
MPNAGELASLMEENAMPKVVVRNFAISLDGYGAGPDQSLQNPLGVKGEELHQWAFKTRTF
HRMFGKEGGSTGTDENFSEKSFENIGAWVLGRNMFGPVRGAWPDESWKGWWGEEPPYHVP
VFVLTHHARPSFTMKGGTEFHFVTDGIEAALDRALTAANGKDVRIGGGVSTIRQYMAAGM
IDELHLALAPVFLGKGEQLFEGLDLPALGYRCTGTVAGEGATHLIIEKV
>Q8G3T8 ## B ## Ba ## Bifidobacterium.longum ## Dihydrofolate reductase. ## Bifidobacterium longum ## Dihydrofolate reductase. ## Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium.
MEHDSSRSGYHEPEPGSAGLSATEEDWGDDYPKTFSVNLIWAEARDKEGRAGAIGLNGGM
PWHCAEDMKHFKELTVSHPVIMGRKTWESLGGKYRPLPNRDNIVVSHDPMYRAPGATVVT
SLDDALDMARQEAIPDDGLDRSEIWIIGGAQLFAKALPFADKAYVTDLAATVDADSYAPD
MASLVEAGMWREAEVGEWHTPAKEESGIDSYRFRILAKTK
>Q82IB4 ## B ## Ba ## Streptomyces.avermitilis ## Hypothetical protein. ## Streptomyces avermitilis ## Hypothetical protein. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MRKIVLMMSVSLDGYIEGPNREIDWHLVDDEVHQHFNDTLRGMGAFLSGRVTYQLMADFW
PTADADPASTGPVADFARIWRDMPKIVFSRTLQHAGWHTTIVRDLVVEDIHALKAQEGGD
LALGGADLAAEFMRHDLVDEYRVYVHPVLLGRGKRLFPETDTLTPLRLTESRTFGNGVAL
LRYERAESTADTAGTNPAAGTADAAGTDRPNGTGS
>Q9RJR8 ## B ## Ba ## Streptomyces.coelicolor ## DNA-binding protein. ## Streptomyces coelicolor ## DNA-binding protein. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MNPGGGPGLPCMTRIIADISISLDGCVTGPDPGPGNGLGTGGEALHTWAFSDDPEERRIV
RETTARSGAVVLGRRLFDLVDGPGGWDDTVGYGAAEVGRPPFVVVTASPPESVRLTGLDW
TFVTTGLPDAVAAARERAEAASADLGRDLDVVLMGGGALIGSALDAGLVEVLSLHLAPVV
LGSGTPLFTGGTPHTLVRRSANATPNATHLLYEVL
>Q9X8Y4 ## B ## Ba ## Streptomyces.coelicolor ## Putative DNA-binding protein. ## Streptomyces coelicolor ## Putative DNA-binding protein. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MDQLLRVQNFTVSRDGVAAGEDQSLERPFGHDVDPGQLFAWAGATANWPNRTEPGGTRGL
DDYFTRDFSHHIGAEIMGRNKFGPQRGPWQDHEWQGWWGDEPPFRTPVFVLTHHARPSFT
LSDTTFHFVDGEPATVLAQAREAARGKDVRLGGGVTTVREFLDAGLVDTLHVAVAPVTLG
SGLRLWDSPEQLLDRYHMEVVPSPSGVTHHLFWRR
>Q9F3M7 ## B ## Ba ## Streptomyces.coelicolor ## Putative secreted protein. ## Streptomyces coelicolor ## Putative secreted protein. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MRSTRRRRERTMRKIIVCTFLTLDGVMQAPGGPDEDAESGFEHGGWQKPVDDDEVGTAIA
GWYEDSDAMLLGRKTYDIFASYWPTADPDNPFTHRMNSMHKYVASRTLTSLDWQNSTLLE
GDTVDAVRRLKASDGGNLNVVGSGDLAQTLMRHGLVDEYRLTIHSVIIGTGKRLFADGAI
PTALEPVSVSVTKGGTVVGVYRPSGAPSYDSY
>AAS51350 ## E ## Ef ## Ashbya.gossypii ## ACR124Wp. ## Ashbya gossypii (Yeast) (Eremothecium gossypii) ## ACR124Wp. ## Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Eremothecium.
MGISRVPVVSIVACLLPEYGIGYQGQLPWRLAREMKYFRQATTATFDPTKRNAVVMGRKT
WESIPARWRPLPGRLNVVVSRTYTSPWAHDENGHVITSNSLQQCVRQLQEQARALGVERI
YIMGGAEIYNQSYDLCDHLLVTELQVAPDGPAVLLDTFLARDVLEQSFAKNSAGPRALLP
PSVELPECPATALEEGGFQFRFALYDHLNRD
>DYR_YEAST ## E ## Ef ## Saccharomyces.cerevisiae ## Dihydrofolate reductase (EC 1. ## Saccharomyces cerevisiae (Baker's yeast) ## Dihydrofolate reductase (EC 1.5.1.3). ## Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
MAGGKIPIVGIVACLQPEMGIGFRGGVPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKT
WESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIY
VIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLP
PKVELPETDCDQRYSLEEKGYCFEFTLYNRK
>AAL25718 ## E ## Ef ## Pneumocystis.carinii ## Dihydrofolate reductase (EC 1. ## Pneumocystis carinii ## Dihydrofolate reductase (EC 1.5.1.3). ## Eukaryota; Fungi; Ascomycota; Pneumocystidomycetes; Pneumocystidaceae; Pneumocystis.
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
>DYR_ENCCU ## E ## Ef ## Encephalitozoon.cuniculi ## Dihydrofolate reductase (EC 1. ## Encephalitozoon cuniculi ## Dihydrofolate reductase (EC 1.5.1.3). ## Eukaryota; Fungi; Microsporidia; Unikaryonidae; Encephalitozoon.
MLALVVALASHRGIGNANALPWPRPLAADMAWFRTLSQSIPLISPDRIALAPSASNAVVM
GRRTWDSIPSRFRPLANRINVVLSRGPARSTENTFFIQTFEALDSLPLPPSSMTFVIGGR
DVYSLALESGRPHLIFATEVFESPECDVFFPHIDWASYEKRDITRDVSRLIDRTLASAFY
SPETATFTENGTSFKMFLYTKPETR
>Q86ZU9 ## E ## Ef ## Coprinus.cinereus ## Dihydrofolate reductase. ## Coprinus cinereus (Inky cap fungus) ## Dihydrofolate reductase. ## Eukaryota; Fungi; Basidiomycota; Hymenomycetes; Homobasidiomycetes; Agaricales; Psathyrellaceae; Coprinopsis.
MSRLTIIVAATKANGIGKGSNLPWRLAKEMKYFARATSEAPEGTRNAVVMGRTTWESIPE
KFRPLPNRVNVVVSRNENYELEPGKEPSPMARLANSLSSGLRHLTTTDGLTVNRIFVIGG
ASLYRETLSLARSKTGPFVDRILLTRIVEPDFDCDVFMPEFNADGKEWTRSTHAELQEWV
GFSVPEGIQEENGVKYEFQMWTRSS
>Q9XBC6 ## B ## Ba ## Amycolatopsis.orientalis ## Hypothetical protein. ## Amycolatopsis orientalis ## Hypothetical protein. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Pseudonocardineae; Pseudonocardiaceae; Amycolatopsis.
MTDTPTRHTNTRRETMRTLISTSFVSLDGKLDPTGGDPALHSTKWTFKTVDFLPEAYEIK
GREQEEAGALLLGRASYELFAPVWPGMAEFARYKGLPKYVVSTTLTENDLVDDWGDNTIL
RSLDEVAELKQTEGDPILVHGSATLNRALHEAGLIDRYHLLVFPILLGAGKPLFSDADLP
ATRLKLVEHEVYPNGIQKQVFDVVR
>Q82LL7 ## B ## Ba ## Streptomyces.avermitilis ## Hypothetical protein. ## Streptomyces avermitilis ## Hypothetical protein. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MGKLTLTAFVTLDGVHQAPGGPEEDRSDGFEQGGWSVPYGDEDFGRFVTDAFARVDAFLL
GRRTYEIFAGYWPKVTDPADPIAAKLNSLPKYVASSSLTDPAWSGTTVIRGDLAKEVAAL
KERTARELQVHGSGALARSLLALDLIDTVHLLTFPVVLGAGRRLFAEGAVPTAFRHVFGS
TTGAGVAIHTYERAGRPTYGSY
>Q9XBD7 ## B ## Ba ## Amycolatopsis.orientalis ## Hypothetical protein. ## Amycolatopsis orientalis ## Hypothetical protein. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Pseudonocardineae; Pseudonocardiaceae; Amycolatopsis.
MATVNCNITISADGYSAGHNQTEQRPFGDDGGDGTGDKLHAWMFDSPEENQAEIDQMTAA
TAFIMGRNMFGPVRGEWDRPWNGWWGDNPPFHGPVFVLTHHERDPQPMDGGTTYHFVTDG
IESALEQARAAAGDGEVTILGGATTINQYLAAGLIDEVRLHIVPFTLGAGTRLFEGVPPL
KLEQVKSRATTSVTHVTYRVLS
>Q8THH7 ## A ## Ae ## Methanosarcina.acetivorans ## Hypothetical protein MA4540. ## Methanosarcina acetivorans ## Hypothetical protein MA4540. ## Archaea; Euryarchaeota; Euryarchaeota orders incertae sedis; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
MKENNPRIKLYIACSLDGFIARKGGSVDWLTEYENSSETDYGYSEFYASIGTVLIGRKTY
EQVLDFGVWPYGEKKTYVFTRQKEPLRREKNVEFVSGNVGEFVRRLKENTDENIWLVGGS
QLIRVFLEEDLVQDMIVFVVPVILGSGIPLFDRIGKEVRLRMIDTERYESGLVKLEYEIE
GRHKKIANHKRKDIQKFG
>Q7UIC9 ## B ## Bo ## Rhodopirellula.baltica ## Dihydrofolate reductase (EC 1. ## Rhodopirellula baltica ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Planctomycetes; Planctomycetacia; Planctomycetales; Planctomycetaceae; Pirellula.
MPSAGDSPSEIARSLRSRDLLPADHGVGCSITAVVAATPNGVIGDDQDMPWRLSSDLKRF
KKATMGGALIMGRKTFESIGRVLPGRQTIVLTRQGHWQFPGTQTASGKSEAIALAADRRI
FVVGGGQIYQQWFPLCTELWWTRVWANVSGDTRVDLPLDEFELVSQTSFPVTAKDDYPTD
WLRMRRRVPRSSLPS
>Q8ET88 ## B ## Bf ## Oceanobacillus.iheyensis ## Hypothetical conserved protein ## Oceanobacillus iheyensis ## Hypothetical conserved protein. ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Oceanobacillus.
MSRKIIYSQMVTLDGYIEGTNGELEWSIPGDELFGFINKKEENIDAHIYGRKMYENMSIW
PSKGQAPDASKEERDWAKHWMKVKKYVISSKLKQEDLQWNTELLNGDMVSSILQLKKIRG
GDISLGGASLAEEFFHYDLIDEVWLFIFPILLGDGKRMFPTMQNQRNYHLKEYKRFDDTV
FLNYERGNNILKGDL
>Q98JM8 ## B ## Bp ## Rhizobium.loti ## Hypothetical protein mll1872. ## Rhizobium loti (Mesorhizobium loti) ## Hypothetical protein mll1872. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Mesorhizobium.
MKKLILQMQMSVDGFVGANDDHRWQLWEWGHDIGWDEELKQDFNAVFAGIDTILLSRKMA
EEGYLTHWGNAAKKFPADPFYAFAQRIVEVRKVVPSDRLKTSRWERSTVVSGDLPREVNA
LKAGEGGDIIVFGGAGFASSLIAAGLVDEFQLFVNPAVLGAGRRIFDQGGFRNLRLLGSK
AYACGMVVNRYAPAQ
>Q8GJL0 ## B ## Bo ## Synechococcus ## Hypothetical protein. ## Synechococcus sp. (strain PCC 7942) (Anacystis nidulans R2) ## Hypothetical protein. ## Bacteria; Cyanobacteria; Chroococcales; Synechococcus.
MGAITPPSSILLSTMTERRLILFIATSLDGYIARRNEGIDWLFDDADYGYSEFYSQIDTV
LMGRKTYELSMSLSDDPYPGCQIYVFSRSLTETADPAITVVQGNPALWVSQLKQQPGRNF
WLVGGGQLVQQCLAADCLDELILSIHPILLGNGIPLFPSPFPEQRWQLVKTQSYPTGLLQ
CTYHRDRSVPSTEP
>Q9UWQ4 ## A ## Ae ## Halobacterium.volcanii ## Dihydrofolate reductase. ## Halobacterium volcanii (Haloferax volcanii) ## Dihydrofolate reductase. ## Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Haloferax.
MSGEELSGSETEGDAAVRFVLVAAVADNRVIGRDGTMPWHLPEDLKQFKRTTTGHPVVMG
RKTYESIARQLGGPLPERHSVLLTTRDLDLPEGAEAVESVESAVAAAEDAADEMGVETVY
VVGGATVYEQFLGRAAGLVLTELDAAHEGDTRFPEWDRGKWVETDRDDRDGFSFVTYERK
QPAAADRGAEESDE
>CAE79248 ## B ## Bp ## Bdellovibrio.bacteriovorus ## Hypothetical protein. ## Bdellovibrio bacteriovorus ## Hypothetical protein. ## Bacteria; Proteobacteria; Deltaproteobacteria; Bdellovibrionales; Bdellovibrionaceae; Bdellovibrio.
MPLHRNYGYHPSLETEDLMKTIYFTAASLDGYIADPNDSLEWLFKNGPTDISFIDTFVNT
VGALAMGTSTYKWMQQHAEEWPYKVPCFVFTHQNLKPFPGADIRFVQGDVASHHKEMQKL
ANGKNIWVVGGGDLAGQFYDQGLLNEMHIQTVAVFLNEGKKLFARHTDTAFKIKNIRQHG
DTCVEVIYSIATT
>Q9F3D0 ## B ## Ba ## Streptomyces.coelicolor ## Hypothetical protein SCO7627. ## Streptomyces coelicolor ## Hypothetical protein SCO7627. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MASLMVDFIISLDGYAAADGWPGFWGMEGPEYLAWLDGDAEKQHTSLMGATTYRLMSGFA
REMPDDPGFEGITAMPKVVFSSTLRTPLSWDNTELVPGDPVPAVRDMKRHGTRPLRTLGS
LTLCRSLLRAGLVDRFRVVVFPVITGATGRERIFDQYPDVTLDLVGSRTFDGRLQLLEYV
PTVLDGPPGADQK
>DYR_CANAL ## E ## Ef ## Candida.albicans ## Dihydrofolate reductase (EC 1. ## Candida albicans (Yeast) ## Dihydrofolate reductase (EC 1.5.1.3). ## Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
MSKPNVAIIVAALKPALGIGYKGKMPWRLRKEIRYFKDVTTRTTKPNTRNAVIMGRKTWE
SIPQKFRPLPDRLNIILSRSYENKIIDDNIIHASSIESSLNLVSDVERVFIIGGAEIYNE
LINNSLVSHLLITEIEHPSPESIEMDTFLKFPLESWTKQPKSELQKFVGDTVLEDDIKEG
DFTYNYTLWTRK
>DYR_CAEEL ## E ## Em ## Caenorhabditis.elegans ## Putative dihydrofolate reducta ## Caenorhabditis elegans ## Putative dihydrofolate reductase (EC 1.5.1.3). ## Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
MRKMNLIVAMDAEGGIGKNGVLPWRIKKDMQYFASVTKNVSDQSKRNAVLMGRKCWESIP
VTRRPLAGRLNIVLSRQLPAQKSDDYIVVNSLEAAMKLLSEPPFVDSIETIWNIGGAEIY
DLALRENLVDEIHLTRIFKNFEADVHLKSLDFSKMEKVQNAEVSSENSEIFEENGLKFEF
CKWKVVENH
>NP_891809 ## V ## Vdd_Caudovirales ## Enterobacteria.phage ## dihydrofolate reductase (produ ## Enterobacteria phage RB49 ## gi|33620593|ref|NP_891809.1| dihydrofolate reductase (product is methyl donor used by dTMP synthase) ##  Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae; T4-like viruses.
MIQCVFAIGDTKMSDENWAFGFKGGLPWGRPIKKDMENFKMRTMGDVELAAVVMGRNTFE
SLPKALEGRLNVVISTDASKPTPKAKNGDQPNVYTGIELKDLLKVLEKTQGLVSVIGGPS
LIEKAVDFADRIVLTYVQRSGINDPFEYDVGISKEMIQELYFDFATKEEHNYFLDDYLIS
EQILERKKA
>Q8VVE6 ## B ## Bp ## Salmonella.typhimurium ## Dihydrofolate reductase. ## Salmonella typhimurium ## Dihydrofolate reductase. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella.
MSHPQLELIVAVDSKLGFGKGGKIPWKCKEDMARFTRISKEIRVCVIGKHTYTDMRDMQL
EKDGAEERIKEKGILPERESFVISSTLKQEDVIGATVVPDLRAVINLYENTDQRIAVIGG
EKLYIQALSSATKLHMTIIPREFDCDRFIPVDPIQNNFHIDSSASETVEATVDETQERIH
FATYVRNNQ
>Q82QN4 ## B ## Ba ## Streptomyces.avermitilis ## Hypothetical protein. ## Streptomyces avermitilis ## Hypothetical protein. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MRKLIYGMNLTLDGYIAAAGDDIGWSGPPSDELFQWWLDQERAISLLLYGRKLWETMSAY
WPTGDQQPNATPAEIEFARNWRDTPKVVFSSTVDKVDWNTRLVSGDAVAEITRLKAEDGG
PMRVGGAALAGAAMRAGLIDEYAIVTHPVLVGSGTPFFTALDSWASLNLVETRTFPGGVV
LTRYETRR
>Q93J84 ## B ## Ba ## Streptomyces.coelicolor ## Hypothetical protein SCO2813. ## Streptomyces coelicolor ## Hypothetical protein SCO2813. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Streptomycineae; Streptomycetaceae; Streptomyces.
MRRVTYSMNVSLDGYIVDPHGAIDWADPAEEVFRFWTDEIRETGAHLLGRRLYETMLYWE
TADRDESLDAAELEWAALWKALPKVVFSRTLTTVQGTNTRLASGTLAEEIERLRAEPGDG
DIAIGAATLAAEAAASDLIDEYRTMVHPVLVGGGTPFFPHHGRRVNLELVESRTFGSHVA
YLRHRVTH
>Q98LQ3 ## B ## Bp ## Rhizobium.loti ## Hypothetical protein mlr0926. ## Rhizobium loti (Mesorhizobium loti) ## Hypothetical protein mlr0926. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Mesorhizobium.
MAKIVYSMLTSLDGYIAGPDGDIGLPVPETELHQHFNDMMRQASAVLAGRRMYETMRFWD
SPDRETGATEVERDFADAWRDTPKIVFSTTLRQVGSNARLVNGDAETAVRSLKTKTDGLV
ILGGADLAADLTRAGLIDEYRLYMHPVVLGGGKPYFQSGLSLALKPLGTESLPQGVTLLR
YAPANQAA
>YYAP_BACSU ## B ## Bf ## Bacillus.subtilis ## Hypothetical protein yyaP. ## Bacillus subtilis ## Hypothetical protein yyaP. ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFLNQIDTILYGRKSFDLW
GQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFINDNILEEVNKLKKNPGKD
IWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFIDVKQRINLKMVNTRTFSSGVV
QIVYHWNG
>AAQ81525 ## V ## Vdd_Caudovirales ## Bacteriophage.44RR2 ## Dihydrofolate reductase. ## Bacteriophage 44RR2.8t ## Dihydrofolate reductase. ## Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae; T4-like viruses.
MIKAVFALGVPSDFHMNGMFAFGKDNDLPWEKIPKDFTLFREKTMGCICVMGAKTFQSLP
FNLPGRVMVVIGDINRSCRNKSGELPALHVNINDHDWMSTVESLYPDQDIAIIGGLGMII
NNLHLCDEIHINFLMLTAEYDTINPSIYISEKSLNRYLGGKQLNSNRYSVDLPHCRSIRE
GVWK
>Q8VVN6 ## B ## Bp ## Vibrio.cholerae ## Dihydrofolate reductase (DhfR1 ## Vibrio cholerae ## Dihydrofolate reductase (DhfR18). ## Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
MNKEIQFSMIVARGVNGEIGQDGDLPWHVEGVRLKEDLKRFKAITMGKTLVMGRKTFESI
PNGLPGRNVIVLTREPYDKADITERGDGTFVAWGNSCHLFEVAEHLGVTEIIVAGGAEIY
NLHKDVITKVFETKVLRAYPAADTHVDVFWESPGYDTEGRQWRVTSRGHIIENGSFTIAT
TYER
>Q7N8I1 ## B ## Bp ## Photorhabdus.luminescens ## Similar to unknown protein. ## Photorhabdus luminescens (subsp. laumondii) ## Similar to unknown protein. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Photorhabdus.
MPKLIYYVATTIDGYIANKNNGLDWLYEFVLGDDATPYDDFYRGIGAVIMGAQTYEWIMT
NSPDDWPYKNVPAFVLSHRALSTPEGLNIIITNETVRVIAAKAKKMANGKDVWLVGGGKT
AAYFAEAGELQQIFLTTIPVFLGAGIEVFPVSEKVHVIPKTQRFLRSGAIESLLDVDAPT
PTP
>AAQ02615 ## E ## Eo ## Hartmannella.cantabrigiensis ## Dihydrofolate reductase. ## Hartmannella cantabrigiensis ## Dihydrofolate reductase. ## Eukaryota; Lobosea; Euamoebida; Hartmannellidae; Hartmannella.
MNGFALVVAVTKTMGIGNKGGLPWSSIRGDMNFLKKITSETKDAAKQNAVIMGRKTYVGI
PAKFRPLSNRVNIVISTNANLRKEESIPDSVHIVDSFDLAVTKAYNLPNIENVFVIGGSS
VYAEAMKHPQCKTIYYTNILTPDFTCDTFFPKIEENVFKVTSRSDLQQEGETSYEFLTYY
RI
>AAS69280 ## B ## Bo ## Leptospira.interrogans ## Hypothetical protein. ## Leptospira interrogans (serogroup Icterohaemorrhagiae / serovar Copenhageni) ## Hypothetical protein. ## Bacteria; Spirochaetes; Spirochaetales; Leptospiraceae; Leptospira.
MRKIILQTMLSMNGYFEGPNSTIDWHVVDEEFNKYTIDFLDQVDVLLFGRITYELMANYW
PTAIVDNPIIATKMNEITKIVFSKTLANVKWKNSILVYNNVKKEVAKLKKQQGKDIAIFG
SSSLAATLIEQKLIDEVRIFINPIVLGEGKTLFQGIQNRISLKLIQTKTFQSGNVLLYYQ
PL
>Q82WU4 ## B ## Bp ## Nitrosomonas.europaea ## Dihydrofolate reductase (EC 1. ## Nitrosomonas europaea ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Proteobacteria; Betaproteobacteria; Nitrosomonadales; Nitrosomonadaceae; Nitrosomonas.
MTIPSLSPPRLAILAAVSANRVIGLNNTLPWHLPADLKHFKQLTTGQIVVMGRRTFDSIG
RPLPDRTNVVLTRQRHFNQPGILTAGSIQEVLEHFCGDDRQIFIIGGAEIYQQTLPFCQR
LYLTEIQQDFAGDTFFPEYDRDNWREISREMHQATDSGIEYHFVVLDRKQPVNAGACSTD
LS
>Q9RW76 ## B ## Bo ## Deinococcus.radiodurans ## Hypothetical protein DR0793. ## Deinococcus radiodurans ## Hypothetical protein DR0793. ## Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae; Deinococcus.
MPRPPLLAFIACSLDGLIARPGGELDWLALAEEPGEDHGYAAFVSRVDTLVMGRGTFETV
RDFPEWPYAGLRVIVLSRTLGEADLPARLHGLLELHSGELPNLLPLLDGAKGVYVDGGQV
LQSFIRAELLDELTVTRLPILLGQGRPLFGPLEADVRWEHVQTRVFDRTGTVQSTYRRLT
TP
>AAQ64077 ## V ## Vdd_Caudovirales ## Bacteriophage.KVP40 ## Dihydrofolate reductase. ## Bacteriophage KVP40 ## Dihydrofolate reductase. ## Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae.
MKVQIVFAHAMSKSPHAPFGNQNALPWKHNKEDLVRFKAATMNSVLVMGSKTFESLPGKL
PHRPHIVLSSSDTATARNGQRADVYCSCDDFGALIKNIENVYLIEGFDKISVIGGPSVIE
SALPFADCIYKTTIVEEIESYDVTIDLTKIFWHFPHRVESEVVECQNGSTIFIEKLTKGD
L
>AAS05185 ## B ## Ba ## Mycobacterium.paratuberculosis ## DfrA. ## Mycobacterium paratuberculosis ## DfrA. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium.
MTRAEVGLVWAQSTSGVIGRGGDIPWSVPEDLTRFKEVTMGHTVIMGRRTWESLPAKVRP
LPGRRNVVVSRRPDFVAEGARVAGSLEAALAHAGSDPAPWVIGGAQIYLLALPHATRCEV
TEIEIDLRRDDDDALAPALDDSWVGETGEWLASRSGLRYRFHSYRRDPRSSVRGCSPSRP
S
>BAD01846 ## B ## Bo ## Synechocystis ## Sll5076 protein. ## Synechocystis sp. (strain PCC 6803) ## Sll5076 protein. ## Bacteria; Cyanobacteria; Chroococcales; Synechocystis.
MKATVYIATSVDGFIARNNGGIDWLPSAGDTDSSEDYGYQEFIDSVDALVMGRNTYELAL
SFDSWPYGEKPVFVLSSRKVDIPEDITKIVESMSVPPREVVCRLSKRGFQHLYIDGGKTI
QGFLSEGLIQQLIITKVPILIGEGIPLFSALPHDVRLHHLETRQFENGLVQSKYKVIEDI
A
>Q813F0 ## B ## Bf ## Bacillus.cereus ## Pyrimidine reductase. ## Bacillus cereus (strain ATCC 14579 / DSM 31) ## Pyrimidine reductase. ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
MGQIIVSMYLSLDGVMEEPAWTAPYFNEEVAKFQSDLLFESEALLLGRVTYQGFAAAWPS
MTDEEGFADKMNSIPKFVASTTLEKTEWNANLIKGNIVEEISKLKEQPGQNLLIYGSGEL
IQTLMQHDLIDEYHFMVNPVIVGSGKHLFKTGNDTKALKLIETRTTSSGVVILSYQPEKK
E
>Q92MK2 ## B ## Bp ## Rhizobium.meliloti ## Hypothetical protein R02614. ## Rhizobium meliloti (Sinorhizobium meliloti) ## Hypothetical protein R02614. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
MRKVIMWDMVSVDGFFEAPGHDIGWFVFEEELDAYIRETQFEAGTLLFGRTTYELMAAYW
PSSRDHIAAFMNGVEKYVFSRTLRSADWNNTTLVSGDAADEVRRLKEREGGAIFIFGSAD
FASTLIAQGLVDEYRLGINPVLLGKGTPLFQNVPERTKLDLTHVRPLKSGVVILHYRPES
A
>Q838Y8 ## B ## Bf ## Enterococcus.faecalis ## Hypothetical protein. ## Enterococcus faecalis (Streptococcus faecalis) ## Hypothetical protein. ## Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
MAREVILFIAASIDGFIADKAGGVAWLEENIRGDEEDRSYDEMYEKIDTVVMGRTTYDQV
TQELSPDVYFYEDKHSYIITSHPEPSTASRTFTKEDPVTLIRRLKEEDGAGIWIVGGPKV
VQPLLAADLIDTFILTTIPLFLGEGIALYETMAQSIPVRLKQVYQKNELVYSIYQRENKN

>Q983M6 ## B ## Bp ## Rhizobium.loti ## Hypothetical protein mll8258. ## Rhizobium loti (Mesorhizobium loti) ## Hypothetical protein mll8258. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Phyllobacteriaceae; Mesorhizobium.
MRKLIVTEFISVDGIAEVEKLPGVTWNDEMNRFKEDELADSGAMLLGRTTYEIFAGSWPE
ETGDFADRFNALPKYVASTSLKALDWKPAELLTGSLPEAVRTLKQGSGGNIYVHGSLSLA
QELLRHGLVDRVRLLSYPGAVGQGKPLFPQGEQVALELISATPFSNGVVALEYAPVAAKS

>Q9HYD7 ## B ## Bp ## Pseudomonas.aeruginosa ## Hypothetical protein PA3469. ## Pseudomonas aeruginosa ## Hypothetical protein PA3469. ## Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
MKPHLIYYVATSLDGFIARPDGSVDWLDRFAEGGNDHGYNGFYQGIDGLLMGRGTYDIVR
GFGDWPYPGKPCQVLTRNPRESAVEGVELRHDTPQEGLARLGEQGCRRVWLAGGGSLAGS
CLAAGLLDEVIVSVIPQLLGAGIPLFAGGRERRLQLLEQHGYNSGIVQMRYQVIAEDDPQ

>Q9RR65 ## B ## Bo ## Deinococcus.radiodurans ## Dihydrofolate reductase. ## Deinococcus radiodurans ## Dihydrofolate reductase. ## Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae; Deinococcus.
MSSQAALCGTVPSRQDIVAIAAQTENRVIGRDGGMPWHLPADFAHFRALSVGKPNIMGRK
VFDTLRRKPLPERVNIVLTRNENLKFDGCLIAHSPEEALQLAGDAPEIAIIGGEEIYRLY
WDRLTRLEMTLIHAELDGDTFFPEIGPEWELAQETFRPADEKNRYDLTFQTWRRRGSGQP

>CAE53346 ## B ## Ba ## Actinoplanes.teichomyceticus ## Hypothetical protein tcp5. ## Actinoplanes teichomyceticus ## Hypothetical protein tcp5. ## Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micromonosporineae; Micromonosporaceae; Actinoplanes.
MSDVSGAGKVVVNRAMSLDGFIAGPGHAMDWIFEYLTGDMFPEVMASTGAMLIGRGTYEV
AKRMAGQGTPYDGGAQFVLTHEPPHEPDPAVTFLSCDIEEAVATARSAAGGKNLEILGAD
VAAQCLRRGLVDEILVYVVPVLLGDGVRFSPPSLDRIDLEPLSNTRSGAVTMLRFRVRK
>DYR_MYCPU ## B ## Bf ## Mycoplasma.pulmonis ## Dihydrofolate reductase (EC 1. ## Mycoplasma pulmonis ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MTMNLIQLLKGKWRFKMIISIWAMTKEGLIGKDNQMPWHIKEEFQHFRRQTLHKTLIMGK
NTFFSLPKVFDKRKMYVLSHEKDFKIDHPDVEVIYDYKDLLKEYANNDKKDIYVAGGLYV
YQQLIPLSDILIVSIVKGSYEGNKYLSVDFSNFVQYKQPEIYDQFSVYYYKKKDQKNSI
>Q88TU1 ## B ## Bf ## Lactobacillus.plantarum ## Reductase (Putative). ## Lactobacillus plantarum ## Reductase (Putative). ## Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
MRKVQFYGAISIDGCLATKDNRLDWLFKTAGANDAPTEAFMQQVDTAIMGRHTYEYTMEQ
TTDQLINPYNPATHNIVMTSHPHTGDERTQFTNTPVTKIVEDLRRTAGKNIWIVGGAGVL
MPLLAADLVDELYIQIAPVILGDGIPLFKAIDQQQRFELVDTNRYGQLAEVHYQRLTTE
>CAG22321 ## B ## Bp ## Photobacterium.profundum ## Putative dihydrofolate reducta ## Photobacterium profundum (Photobacterium sp. (strain SS9)) ## Putative dihydrofolate reductase. ## Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Photobacterium.
MSNIVYIATSLDGYIADKNGSIDWLHTTPSPDGSDLGYSNFIERIDALVMGRNTLDMVLS
FDCDWPYTRPVFVLSNTMTRIPEGYEDKIFLVKGPLTTVVASLNEQGYNNLYIDGGITIQ
NFLKEDLIDEMIITTIPILLGGGSPLFGELVTPQSFELTGSEILINQLVQSHFTRIR
>DYR9_ECOLI ## B ## Bp ## Escherichia.coli ## Dihydrofolate reductase type I ## Escherichia coli ## Dihydrofolate reductase type IX (EC 1.5.1.3). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
MASLNMIVAVNKTGGIGFENQIPWHEPEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRL
HVVVSKTVPPTQNTDQVVYVSTYQIAVRTASLLVDKPEYSQIFVIGGKSAYENLAAYVDK
LYLTRVQLNTQQDTELDLSLFKSWKLVSEVPTITENKTKLIFQIWINPNPISEEPTC
>AAR34946 ## B ## Bp ## Geobacter.sulfurreducens ## RibD domain protein. ## Geobacter sulfurreducens ## RibD domain protein. ## Bacteria; Proteobacteria; Deltaproteobacteria; Desulfuromonadales; Geobacteraceae; Geobacter.
MDVIYYVAASLDGYIATPDGGVAWLAPFENAGEDYGYAEFYASVDALLMGSATYEKTLSF
GAWPYEGKPCRVFSRQEHAVPTHDVVITDATPDDVLHSLLRNGCRRAWLVGGGVLAASFL
QRRLISEYIVSIVPVILGGGIPMISPNRIRESLTLLETKVCTGGIVQVRYRSEGH
>Q8U769 ## B ## Bp ## Agrobacterium.tumefaciens ## Hypothetical protein Atu4585. ## Agrobacterium tumefaciens (strain C58 / ATCC 33970) ## Hypothetical protein Atu4585. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium.
MAVIRGYIAASLDGQIVSGDGSLDWLFKYDDMDLGEHDYRLFLKGIRTVVMGRATYDFIA
SEQSPWVYGDQRVIVVTSRPIEEPKGPLEVYNDVGSLIRELRALDDGDVWMLGGGKLQMA
FLERGALDEIEIYVIPEILGSGEPLFPLTGHRASPTLVSATAIEKGCVRLHYRFS
>AAT05310 ## B ## Bf ## Listeria.monocytogenes ## Hypothetical protein. ## Listeria monocytogenes str. 4b F2365 ## Hypothetical protein. ## Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria; Listeria monocytogenes.
MSEKQVALYIAVSLDGYIADENGSVEWLESIDSEGDAGYEAFFDNVDTVVMGRTTYQQIF
SLTDTFPYSKKDVYVFSNTKAGTKDEYADFVAGTVDTWLNNIDGEKIWLVGGAKLVQQFL
KEKAIDRFVITIAPIILGKGIPLFEEDREHALELEEVTRFGQFAQLTYKNLEEN
>NP_803570 ## V ## Vdd_Caudovirales ## Pseudomonas.phage ## ORF004 ## Pseudomonas phage phiKZ ## gi|29134940|ref|NP_803570.1| ORF004 ##  Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae.
MAIKLIVAHDLNGVIGYNNLLPWHIPEDLAFFKEMTTGCCVIMGKNTFLSLGSKPLPNRN
NIVVSSSLYRNGNYPVAYDNKLGVLPNLSAAIVYATHFNKETGKDVWIIGGSQLYKEVIE
KDILDEMYITTVKMEIDNSSCVYFPKEIIKWDKWKSTIIKETDLCTYTHWIKT
>Q9CE85 ## B ## Bf ## Lactococcus.lactis ## Hypothetical protein yudH. ## Lactococcus lactis (subsp. lactis) (Streptococcus lactis) ## Hypothetical protein yudH. ## Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
MTVKLFIASTLDGYIATKEESLQWLFDVEGEGDNGYGAFYSDIGTIIMGKKTYDWLEKEQ
AGQWPYSDKTSYILTHQKISSTDNIVFIDKEKLTELSVNFADTDKNIWVVGGGEVIKLFI
ENHWVDELQVTIAPVLLGDGISLFPSGNYKEKLQLIDTKIYGQFVELHYLVKK
>AAQ17977 ## V ## Vdd_Caudovirales ## Bacteriophage.Aeh1 ## Frd dihydrofolate reductase. ## Bacteriophage Aeh1 ## Frd dihydrofolate reductase. ## Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae; T4-like viruses.
MIKAVFATGKFGEFGNKNGLPWGHCRVDMLNFMETTKDSCLLMGAKTFMSLPTKLKNRVN
VVLSTSNDTNRVVAKNGERPDMFMHGDVTQALSELQTLYNNICVIGGMTVLKEAIDMADQ
VVHTVILNEEKLECDVELDETVQEKITSDFYVLSNKFLGDEAITYTSVRKKK
>CAE78048 ## B ## Bp ## Bdellovibrio.bacteriovorus ## FolA protein (EC 1.5.1.3). ## Bdellovibrio bacteriovorus ## FolA protein (EC 1.5.1.3). ## Bacteria; Proteobacteria; Deltaproteobacteria; Bdellovibrionales; Bdellovibrionaceae; Bdellovibrio.
MILTHVVACSQNRVIGAQGGLPWSLPEDMKFFRETTKGHIMIMGRKTFDSFNGRALPNRY
HIVVTRDPSKQSFNSTESSPVVFVASIEEAVKHAEPLTAKWGDEVFIIGGGEIYKQAMPI
TDKIYLTLIHREFPGDTYYPEIDEKVFTQTERRDIETPIPFSFLTYLRK
>DYR8_ECOLI ## B ## Bp ## Escherichia.coli ## Dihydrofolate reductase type V ## Escherichia coli, and Shigella sonnei ## Dihydrofolate reductase type VIII (EC 1.5.1.3) (DHFR type IIIC). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia.
MIELHAILAATANGCIGKDNALPWPPLKGDLARFKKLTMGKVVIMGRKTYESLPVKLEGR
TCIVMTRQALELPGVRDANGAIFVNNVSDAMRFAQEESVGDVAYVIGGAEIFKRLALMIT
QIELTFVKRLYEGDTYVDLAEMVKDYEQNGMEEHDLHTYFTYRKKELTE
>DYR_THEMA ## B ## Bo ## Thermotoga.maritima ## Dihydrofolate reductase (EC 1. ## Thermotoga maritima ## Dihydrofolate reductase (EC 1.5.1.3) (DHFR). ## Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
MAKVIFVLAMDVSGKIASSVESWSSFEDRKNFRKITTEIGNVVMGRITFEEIGRPLPERL
NVVLTRRPKTSNNPSLVFFNGSPADVVKFLEGKGYERVAVIGGKTVFTEFLREKLVDELF
VTVEPYVFGKGIPFFDEFEGYFPLKLLEMRRLNERGTLFLKYSVEKSHR
>Q7NHQ9 ## B ## Bo ## Gloeobacter.violaceus ## Dihydrofolate reductase. ## Gloeobacter violaceus ## Dihydrofolate reductase. ## Bacteria; Cyanobacteria; Chroococcales; Gloeobacter.
MELIAVVAMDSRRLIGRGDGLPWHCPEDLSAFKALTWGQPLLMGRRTFESILARRGKPLP
EREHYVLTARRGPSFPTVRYICSPDQALALPVERLFVIGGASVYAQTADQLDTLYLSLIP
GLHTGDVFLPDLGNRWAVEIIEKFQTFKRWRLLRSPSVGFDWSQLVEGG
>Q7VQK5 ## B ## Bp ## Candidatus.Blochmannia ## Dihydrofolate reductase type I ## Candidatus Blochmannia floridanus ## Dihydrofolate reductase type I (EC 1.5.1.3). ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
MIISLIAAFTINYVIGRKNIIPWYFSWDMMWFKYHTMYKPVIMGRKTFESMNSKPLPYRL
NIVLSKHHILYNNKIHNIFIACNPIQALSVVQKNDEVMIIGGGLVYNAFMSQCTRMYLTK
IDVVYNYGDSWFPSYNPNEWCVVYNTNKKCVINTGYTYNLNFQILDRT
>AAS09238 ## B ## Bf ## Lactobacillus.johnsonii ## Dihydrofolate reductase. ## Lactobacillus johnsonii ## Dihydrofolate reductase. ## Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
MIRFIWAEDENGCIGYQGALPWHLPADLKHFKELTSNHIIVMGRKTFDSFPGLLPKRKHI
ILSTNPILQRRYQDNSDVKVFSQIEQLKNWIEDHTEEIIDIIGGAEVFKEFKDEVDVLEK
TKIHHIFKCDTWMPELKYEDFKLVNSESHHPNGNNKFDYDFLEYKRI
>DYR_ENTFC ## B ## Bf ## Enterococcus.faecium ## Dihydrofolate reductase (EC 1. ## Enterococcus faecium (Streptococcus faecium) ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
MFISMWAQDKNGLIGKDGLLPWRLPNDMRFFREHTMDKILVMGRKTYEGMGKLSLPYRHI
IVLTTQKDFKVEKNAEVLHSIDELLAYAKDIPEDIYVSGGSRIFQALLPETKIIWRTLID
AEFEGDTFIGEIDFTSFELVEEHEGIVNQENQYPHRFQKWQKMSKVV
>AAS66087 ## B ## Bp ## Salmonella.enterica ## Dihydrofolate reductase type A ## Salmonella enterica subsp. enterica serovar Livingstone ## Dihydrofolate reductase type A21. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella; Salmonella enterica.
MNPESVRIYLVAAMGANRVIGNGPDIPWKIPGEQKIFRRLTESKVVVMGRKTFESIGKPL
PNRHTVVLSRQARYSAPGCAVVSTLSQAIAIAAEHGKELYVAGGAEVYALALPHANGVFL
SEVHQTFEGDAFFPVLNAAEFEVVSSETIQGTITYTHSVYARRNG
>Q9RNJ3 ## B ## Bp ## Zymomonas.mobilis ## Dihydrofolate reductase typeII ## Zymomonas mobilis ## Dihydrofolate reductase typeIII. ## Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales; Sphingomonadaceae; Zymomonas.
MPSLSEIMLIFARAQNGVIGKDNTMPWHISADLKHFKALTLGHPMIMGRRTFESLPGLLP
KRPHIVLTHNHHWQAEGAEAGCDLEEAIKAARKYSSQIAVIGGANIFQQFWDKADRIELT
EIYRDYSGDTFVDLPDMNHFSLVGQEDFKAEGECPAFSFKSFLRK
>Q7P634 ## B ## Bo ## Fusobacterium.nucleatum ## Dihydrofolate reductase (EC 1. ## Fusobacterium nucleatum subsp. vincentii ATCC 49256 ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Fusobacteria; Fusobacterales; Fusobacteriaceae; Fusobacterium; Fusobacterium nucleatum.
MRKKYYKNLKLIVCVGKDNLIGDRTPDEDSNGMLWHIKEELIYFKSKTVGNTVLFGGTTA
KYVPVELMKKNREVITLHRNMDIPKLIEDLTLQNKTIFIAGGYSIYKYFLDNFEIDEIFL
SKIKDSVEVKKAVEPLYFPNIEDYGYKIVDKKDYEEFVAYVYKK
>Q7PAE3 ## B ## Bp ## Rickettsia.sibirica ## Dihydrofolate reductase. ## Rickettsia sibirica ## Dihydrofolate reductase. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Rickettsieae; Rickettsia.
MKNRKIIGIMACDPQGVIGNKGQMPWSYTKEFEYFYQTVKNNIIVMGRKTFDSIPTKILK
NCICIVFSRNTPLQSYNNIFFIKSLDDFWQVIKPFTDKKIFMVGGTEIATLFLEQNLIDE
FLLTKINKNYDGDTFLPLNLLAEWHSVIIDKTNNYQIYKFTKRR
>Q834R2 ## B ## Bf ## Enterococcus.faecalis ## Dihydrofolate reductase. ## Enterococcus faecalis (Streptococcus faecalis) ## Dihydrofolate reductase. ## Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
MLAAIWAQDEQGVIGKEGKLPWHLPNDLKFFKEKTIHNTLVLGRATFEGMGCRPLPNRTT
IVLTSNPDYQAEGVLVMHSVEEILAYADKYEGVTVIGGGSVVFKELIPACDVLYRTMIHE
TFEGDTFFPEIDWSVWEKVATVPGVVDEKNLYAHDYETYHRNDK
>Q9ZIF9 ## B ## Bf ## Enterococcus.faecalis ## Dihydrofolate reductase. ## Enterococcus faecalis (Streptococcus faecalis) ## Dihydrofolate reductase. ## Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
MIGLIVARSKNNVIGKNGNIPWKIKGEQKQFRELTTGNVVIMGRKSYEEIGHPLPNRMNI
VVSTTTEYQGDNLVSVKSLEDALLLAKGRDVYISGGYGLFKEALQIVDKMYITEVDLNIE
DGDTFFPEFDINDFEVLIGETLGEEVKYTRTFYVRKNELSRFWI
>BAD04379 ## B ## Bf ## Onion.yellows ## Dihydrofolate reductase. ## Onion yellows phytoplasma ## Dihydrofolate reductase. ## Bacteria; Firmicutes; Mollicutes; Acholeplasmatales; Acholeplasmataceae; Phytoplasma.
MINLITAFDGNYLIGKDNKLPWHYSQDLQYFKKITLNQNVLMGYETYKSLKNYFKNKPFN
FKKTYVASLKHDLELPNCTVVSDLQSFMASDAAQDIFIIGGGKIYQQTLPWVTTLYITHI
LQRHQGNVFFPKIDLSQYQLIQKEIHPQLIFAIYQKKLDTPKC
>Q88W06 ## B ## Bf ## Lactobacillus.plantarum ## Dihydrofolate reductase (EC 1. ## Lactobacillus plantarum ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
MIALIWAEDQNGLIGNQGQLPWHLPADMQRFKALTTGHHVVMGRKTFAGFKRPLPRRTNW
VLSRQSDLKLPPEVHQLADVAAIQTLAAAHPDEPIFVIGGAVVFEAVLPVADYLYRTRIN
ARFDGDTWMPAVDYTQWQLVSQQIGTVDEKNQYPYEFDDFRRR
>Q8KQF2 ## B ## Bp ## Methylobacterium.extorquens ## Dihydrofolate reductase. ## Methylobacterium extorquens ## Dihydrofolate reductase. ## Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Methylobacteriaceae; Methylobacterium.
MDVRLIAAIGRRGQLGLEGDMPWGRSFPDDLRRFRELTAGGIVLVGWRTWPTVERLQGTH
GRRFVVDDVKLPPTGMLVRLQEPDASGTRDRPVWIAGGAKTYARYARFVDEFVVRRVPYD
GPADTWMPDLLGTPEADRTDGPYTGRSPTDKQWRPGCRRLRDR
>DYR_HALVO ## A ## Ae ## Halobacterium.volcanii ## Dihydrofolate reductase (EC 1. ## Halobacterium volcanii (Haloferax volcanii) ## Dihydrofolate reductase (EC 1.5.1.3). ## Archaea; Euryarchaeota; Halobacteria; Halobacteriales; Halobacteriaceae; Haloferax.
MELVSVAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSA
QIVMSRSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSR
VPGEYEGDTYYPEWDAAEWELDAETDHEGFTLQEWVRSASSR
>DYR_LACCA ## B ## Bf ## Lactobacillus.casei ## Dihydrofolate reductase (EC 1. ## Lactobacillus casei ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
TAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNV
VLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAG
SFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
>Q8D3H9 ## B ## Bp ## Wigglesworthia.glossinidia ## FolA protein. ## Wigglesworthia glossinidia brevipalpis ## FolA protein. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Wigglesworthia.
MDISLIWAQSKNKVIGHDQYIPWNLPEDISWFKKNTINKPVIMGRKTFESIKKPLENRIN
IVLSKNLYRNVMSNLKIAKNPKQALFFAKNYNEVMIIGGKQIYKIFLPKATKLYLTVINA
EINGNIFFPRYNRKKWILSFEKYFNSDTKNKYSMYFRIFNKI
>Q7QLX6 ## E ## Em ## Anopheles.gambiae ## EbiP349 (Fragment). ## Anopheles gambiae str. PEST ## EbiP349 (Fragment). ## Eukaryota; Metazoa; Arthropoda; Mandibulata; Pancrustacea; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Anopheles; Anopheles gambiae.
IMITIVVAIGKNNEIGKGNQLLWHLPKDLKHFKEITNGHPVIMGRKTYDSIGKALPNRTN
IVVTRKTDWFEEGILIVNTLKEALKHAKKIDEKVFVIGGGDIYKQCMEVADSIELTRVDG
TFDADVFFPEINEKQWRIVQEECIEKDDKNAFDFCFQTFER
>Q8ET87 ## B ## Bf ## Oceanobacillus.iheyensis ## Hypothetical conserved protein ## Oceanobacillus iheyensis ## Hypothetical conserved protein. ## Bacteria; Firmicutes; Bacillales; Bacillaceae; Oceanobacillus.
MSLDRYITGKDDSTQQPLGIGGKSLQNWMFQGSFASEYNNFFTMSEVNRRIFDQPIRSIG
EMVVGRRTFDIVNGWNGSHPIAGIPIVVVTHEPPNEYAEQDTIFHFASGFHRAIDTARQI
VGDKEVSIGSASNVEKLADELHLHITPVLLGEGKKLFVRSN
>Q8XPC1 ## B ## Bf ## Clostridium.perfringens ## Probable dihydrofolate reducta ## Clostridium perfringens ## Probable dihydrofolate reductase. ## Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
MFSIIVAKSINNIIGVNNKMPWNIPSDLKRFKELTMGKKILMGRKTFESLPFVLPGRTHL
VLTTKKDFSYNHKDIIIYNDLNKLIEEYKDSKEEIFVIGGGKIYSELLKYTSKLYITEVL
KEYKGDTYFPKVDYSKWIKTYESSIYEENDNKFKFFNYKKI
>AAT04672 ## B ## Bf ## Listeria.monocytogenes ## Dihydrofolate reductase (EC 1. ## Listeria monocytogenes str. 4b F2365 ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Bacillales; Listeriaceae; Listeria; Listeria monocytogenes.
MIIFVWAQDRAGNIGKDNKMPWHLPGDLQFFKKTTTGKTLVMGRKTYESLGKALPNRKTI
VLTRDQGLKLDDAEILHSKEAVLALAETGETIYIVGGAEIYRLFMDVADQLIVTKIDAEF
EADTAFPEVDWENFSEVAKEFHEKDEKNKYNYTFYTYERN
>AAS14564 ## B ## Bp ## Wolbachia.pipientis ## Dihydrofolate reductase (EC 1. ## Wolbachia pipientis wMel ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Rickettsiaceae; Wolbachieae; Wolbachia.
MIVIGIMAVDPKGVIGINNGLPWHYPSELDHFRQVTEKQVIVMGRKTFETMPQDILGNRI
PVVFSRDKLNSCFNRGVKCTIISSMQEFLSIQSNSKVFMIGGAQIAYLFLEYDLISEFII
TEIHKPYKGDVYFNLTLLDGWHKTILTKTKDYTICKLTR
>Q8GCW7 ## B ## Bp ## Citrobacter.freundii ## Dihydrofolate reductase type I ## Citrobacter freundii ## Dihydrofolate reductase type IIIb. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Citrobacter.
MTKQAIFAVAENLAFGLGGGLPWDTLKDDLQFFKRLTEGTDLVMGASTYRTLPLLPTNNR
QFIVVSNTEEPSLNVHVVSPEHFKAFLSKTSRNLTIIGGSSLLTVDILSKMDKIIMTTVY
GSFDADVYLPTEVVSYVTGKASNATLFNNSDAKMAVYYG
>Q934V0 ## B ## Bp ## Salmonella.typhi ## Putative dihydrofolate reducta ## Salmonella typhi ## Putative dihydrofolate reductase. ## Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Salmonella.
MKMIAAVGRNYEIGIGNELPWRCPTDLKLFKQLTKNATVVMGRKTMESLKRPLPERHNLV
LTRSRGYIPNGFYPAGIDDVLRLPDPVWVIGGGQIYSLFMPHVEEIWLSHIGVDVPGADA
FFPAPMMRSLGFVPVETAYTQRANEDEPGFLQIVYRRS
>DYR_UREPA ## B ## Bf ## Ureaplasma.parvum ## Dihydrofolate reductase (EC 1. ## Ureaplasma parvum (Ureaplasma urealyticum biotype 1) ## Dihydrofolate reductase (EC 1.5.1.3). ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
MLKLIWCQTLNGGISKNNKLPWYIKEELDHFYKTTKNHKIIMGKNTFDSLDQKPLNNRTN
IIFSSIMQTPEDESYFVTNDFQQVLNDAKKEDIFIIGGKELFDIFLAYADVLIVSVLKDY
YDCDLYMKVDYNNFNLDKQDVYDNFIVNYYSNKKEK
>Q8EV82 ## B ## Bf ## Mycoplasma.penetrans ## Dihyrofolate reductase. ## Mycoplasma penetrans ## Dihyrofolate reductase. ## Bacteria; Firmicutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
MFISIWCEDKNRGIGKNNKLPWNIKEDLNLFKKHTLNNTIVMGKNTFLSIGKALPNRKNI
VISKTLDASLYKDIEVYDDIEQFYNEYKNRDESIFIIGGKSIYDYFINKCSILYVSKLNS
AYECDLFMDNSFDGFEIVNQKEYEQFTFFEYRKV
>Q97EV2 ## B ## Bf ## Clostridium.acetobutylicum ## Dihydrofolate reductase. ## Clostridium acetobutylicum ## Dihydrofolate reductase. ## Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
MLSIIAALNENYVIGNENKLIWHISDDLKRFKKLTTGKTIIMGRKTFESLPGVLPNRKHI
VITKNLNYSRENVSIVHSIDEIIELKDTTEENFIIGGGEIYRALIPYCSILYLTKVHSNQ
TGDAFFPKFDENDYSIIATEKHGDYDFVTFKRR
>DRTS_MAIZE ## E ## Ep ## Zea.mays ## Bifunctional dihydrofolate red ## Zea mays (Maize) ## Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) [Includes: Dihydrofolate reductase (EC 1.5.1.3); Thymidylate synthase (EC 2.1.1.45)]. ## Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; PACCAD clade; Panicoideae; Andropogoneae; Zea.
MAAVLANGDSQGRPQRNYQVVVAGTRDMGIGKDGVLPWKLPGDLKFFKELTLTTSDPVKK
NAVIMGRKTWESIPVKSRPLPGRLNVILTRSGSFDFATVENVVICGSMESALELLASTPY
CLSIEKVFVIGGGQVLREYLKGPACEAIHLTDIQSSIECDTFIPPVDFSVFQPWYSSFPV
IESNIRHSFVSFVRVRKSVAETHESNGKESTEVDTKNDKFETENFSFLPKMVYDRHEEYQ
YLNLVEDIIRSGAQKNDRTGTGTLSKFGCQMRFNLRKNFPLLTTKRVFWRGVVEELLWFI
SGSTNAKVLQEKGIHIWDGNASREYLNSVGLAHREEGDLGPIYGFQWRHFGAEYTDMHAD
YTGKGFDQLMDVIDKIKNDPEDRRIILSAWNPSDLKKMALPPCHMFAQFYVENGELSCQM
YQRSADMGLGVPFNIASYSLLTYMIAQVCDLSPGDFVHVIGDAHVYRNHVRALEEQIQKM
PKPFPILKINPSKKDIDSFMASDFKLVGYDPHQKIEMKMAV
>Q8L6F0 ## E ## Ep ## Pisum.sativum ## Dihydrofolate reductase-thymid ## Pisum sativum (Garden pea) ## Dihydrofolate reductase-thymidylate synthase (EC 1.5.1.3). ## Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; rosids; eurosids I; Fabales; Fabaceae; Papilionoideae; Vicieae; Pisum.
MAADSSVMFNGNGNGSINPMPNLQRTYQVVVAATKDMGIGKDGKLPWRLPTDLKFFKELT
TTTFETGKKNAIVMGRKTWESIPLQFRPLPGRLNVVLTRSGSFDAKAAENVVICGSMSSA
LELLAASPYCTSIEKIFVIGGGEIFRDALNVPECEAIHITEIHTSFECDTFMPPIDFTTF
RPWYSSFPKVENNIRYSFTTYVRVRSSVAESLNQSTVSPLDNKPASKKFEVQNFSFLPKM
IFERHEEYMYLNLVQEIISQGTSKGDRTGTGTLSKFGCQMRFNLRRGFPLLTTKRVFWRG
VVEELLWFISGSTNAKVLQEKGIHIWDDNASREFLDSIGLSEREEGDLGPVYGFQWRHFG
ARYTNMHNDYAGQGVDQLLDVINKVKHNPDDRRIILSAWNPADLKLMALPPCHMSAQFYV
ANGELSCQMNQRSADMGLGVPFNIASYALLTCMIAHICELVPGDFIHVLGDAHVYQTHVR
PLQEQLHNLPKPFPTLKINSKKKDIDSFVATDFKLIDYDPHQKIEMKMAV
>AAM45080 ## E ## Ep ## Arabidopsis.thaliana ## Putative dihydrofolate reducta ## Arabidopsis thaliana (Mouse-ear cress) ## Putative dihydrofolate reductase-thymidylate synthase. ## Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicots; Rosidae; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
MATTTLNDSVTTTLASEPQRTYQVVVAATKEMGIGKDGKLPWNLPTDLKFFKDITLTTSD
SSKKNAVVMGRKTWESIPIKYRPLSGRLNVVLTRSGGFDIANTENVVTCSSVDSALDLLA
APPYCLSIERVFVIGGGDILREALNRPSCDAIHLTEIDTSVDCDTFIPAIDTSVYQPWSS
SFPVTENGLRFCFTTFVRVKSSADESSDESNGSQSLQFDGKKFLFLPKMVFDQHEEFLYL
NMVEDIISNGNVKNDRTGTGTLSKFGCQMKFNLRRSFPLLTTKRVFWRGVVEELLWFISG
STNAKVLQEKGIHIWDGNASREYLDGIGLTEREEGDLGPVYGFQWRHFGAKYTDMHADYT
GQGFDQLVDVIDKIKNNPDDRRIIMSAWNPSDLKLMALPPCHMFAQFYVAEGELSCQMYQ
RSADMGLGVPFNIASYSLLTCMLAHVCDLVPGDFIHVLGDAHVYKTHVRPLQEQLLNLPK
PFPVMKINPEKKQIDSFVASDFDLTGYDPHKKIEMKMAV